Apolipoprotein E4 effects on topological brain network organization in mild cognitive impairment

Abstract The Apolipoprotein E isoform E4 (ApoE4) is consistently associated with an elevated risk of developing late-onset Alzheimer’s Disease (AD); however, less is known about the potential genetic modulation of the brain networks organization during prodromal stages like Mild Cognitive Impairment...

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Autores principales:	Gretel Sanabria-Diaz, Lester Melie-Garcia, Bogdan Draganski, Jean-Francois Demonet, Ferath Kherif
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56d58ac93a3b44fe9f12ec546a06c059
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spelling	oai:doaj.org-article:56d58ac93a3b44fe9f12ec546a06c0592021-12-02T14:01:20ZApolipoprotein E4 effects on topological brain network organization in mild cognitive impairment10.1038/s41598-020-80909-72045-2322https://doaj.org/article/56d58ac93a3b44fe9f12ec546a06c0592021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80909-7https://doaj.org/toc/2045-2322Abstract The Apolipoprotein E isoform E4 (ApoE4) is consistently associated with an elevated risk of developing late-onset Alzheimer’s Disease (AD); however, less is known about the potential genetic modulation of the brain networks organization during prodromal stages like Mild Cognitive Impairment (MCI). To investigate this issue during this critical stage, we used a dataset with a cross-sectional sample of 253 MCI patients divided into ApoE4-positive (‛Carriers’) and ApoE4-negative (‘non-Carriers’). We estimated the cortical thickness (CT) from high-resolution T1-weighted structural magnetic images to calculate the correlation among anatomical regions across subjects and build the CT covariance networks (CT-Nets). The topological properties of CT-Nets were described through the graph theory approach. Specifically, our results showed a significant decrease in characteristic path length, clustering-index, local efficiency, global connectivity, modularity, and increased global efficiency for Carriers compared to non-Carriers. Overall, we found that ApoE4 in MCI shaped the topological organization of CT-Nets. Our results suggest that in the MCI stage, the ApoE4 disrupting the CT correlation between regions may be due to adaptive mechanisms to sustain the information transmission across distant brain regions to maintain the cognitive and behavioral abilities before the occurrence of the most severe symptoms.Gretel Sanabria-DiazLester Melie-GarciaBogdan DraganskiJean-Francois DemonetFerath KherifNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gretel Sanabria-Diaz Lester Melie-Garcia Bogdan Draganski Jean-Francois Demonet Ferath Kherif Apolipoprotein E4 effects on topological brain network organization in mild cognitive impairment
description	Abstract The Apolipoprotein E isoform E4 (ApoE4) is consistently associated with an elevated risk of developing late-onset Alzheimer’s Disease (AD); however, less is known about the potential genetic modulation of the brain networks organization during prodromal stages like Mild Cognitive Impairment (MCI). To investigate this issue during this critical stage, we used a dataset with a cross-sectional sample of 253 MCI patients divided into ApoE4-positive (‛Carriers’) and ApoE4-negative (‘non-Carriers’). We estimated the cortical thickness (CT) from high-resolution T1-weighted structural magnetic images to calculate the correlation among anatomical regions across subjects and build the CT covariance networks (CT-Nets). The topological properties of CT-Nets were described through the graph theory approach. Specifically, our results showed a significant decrease in characteristic path length, clustering-index, local efficiency, global connectivity, modularity, and increased global efficiency for Carriers compared to non-Carriers. Overall, we found that ApoE4 in MCI shaped the topological organization of CT-Nets. Our results suggest that in the MCI stage, the ApoE4 disrupting the CT correlation between regions may be due to adaptive mechanisms to sustain the information transmission across distant brain regions to maintain the cognitive and behavioral abilities before the occurrence of the most severe symptoms.
format	article
author	Gretel Sanabria-Diaz Lester Melie-Garcia Bogdan Draganski Jean-Francois Demonet Ferath Kherif
author_facet	Gretel Sanabria-Diaz Lester Melie-Garcia Bogdan Draganski Jean-Francois Demonet Ferath Kherif
author_sort	Gretel Sanabria-Diaz
title	Apolipoprotein E4 effects on topological brain network organization in mild cognitive impairment
title_short	Apolipoprotein E4 effects on topological brain network organization in mild cognitive impairment
title_full	Apolipoprotein E4 effects on topological brain network organization in mild cognitive impairment
title_fullStr	Apolipoprotein E4 effects on topological brain network organization in mild cognitive impairment
title_full_unstemmed	Apolipoprotein E4 effects on topological brain network organization in mild cognitive impairment
title_sort	apolipoprotein e4 effects on topological brain network organization in mild cognitive impairment
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/56d58ac93a3b44fe9f12ec546a06c059
work_keys_str_mv	AT gretelsanabriadiaz apolipoproteine4effectsontopologicalbrainnetworkorganizationinmildcognitiveimpairment AT lestermeliegarcia apolipoproteine4effectsontopologicalbrainnetworkorganizationinmildcognitiveimpairment AT bogdandraganski apolipoproteine4effectsontopologicalbrainnetworkorganizationinmildcognitiveimpairment AT jeanfrancoisdemonet apolipoproteine4effectsontopologicalbrainnetworkorganizationinmildcognitiveimpairment AT ferathkherif apolipoproteine4effectsontopologicalbrainnetworkorganizationinmildcognitiveimpairment
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Apolipoprotein E4 effects on topological brain network organization in mild cognitive impairment

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