Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

Glycoprotein ZP1 is a component of the oocyte’s zona pellucida (ZP), and mutations in human ZP1 are linked to female infertility. Here, using structure-function analysis, the authors suggest that filament cross-linking by ZP1 is required to form a stable ZP in human, and infertility mutations interf...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kaoru Nishimura, Elisa Dioguardi, Shunsuke Nishio, Alessandra Villa, Ling Han, Tsukasa Matsuda, Luca Jovine
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/56d66a23508b4bf9b30688e79a38ded7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:56d66a23508b4bf9b30688e79a38ded7
record_format	dspace
spelling	oai:doaj.org-article:56d66a23508b4bf9b30688e79a38ded72021-12-02T14:39:36ZMolecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility10.1038/s41467-019-10931-52041-1723https://doaj.org/article/56d66a23508b4bf9b30688e79a38ded72019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10931-5https://doaj.org/toc/2041-1723Glycoprotein ZP1 is a component of the oocyte’s zona pellucida (ZP), and mutations in human ZP1 are linked to female infertility. Here, using structure-function analysis, the authors suggest that filament cross-linking by ZP1 is required to form a stable ZP in human, and infertility mutations interfere with cross-linking.Kaoru NishimuraElisa DioguardiShunsuke NishioAlessandra VillaLing HanTsukasa MatsudaLuca JovineNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kaoru Nishimura Elisa Dioguardi Shunsuke Nishio Alessandra Villa Ling Han Tsukasa Matsuda Luca Jovine Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
description	Glycoprotein ZP1 is a component of the oocyte’s zona pellucida (ZP), and mutations in human ZP1 are linked to female infertility. Here, using structure-function analysis, the authors suggest that filament cross-linking by ZP1 is required to form a stable ZP in human, and infertility mutations interfere with cross-linking.
format	article
author	Kaoru Nishimura Elisa Dioguardi Shunsuke Nishio Alessandra Villa Ling Han Tsukasa Matsuda Luca Jovine
author_facet	Kaoru Nishimura Elisa Dioguardi Shunsuke Nishio Alessandra Villa Ling Han Tsukasa Matsuda Luca Jovine
author_sort	Kaoru Nishimura
title	Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
title_short	Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
title_full	Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
title_fullStr	Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
title_full_unstemmed	Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility
title_sort	molecular basis of egg coat cross-linking sheds light on zp1-associated female infertility
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/56d66a23508b4bf9b30688e79a38ded7
work_keys_str_mv	AT kaorunishimura molecularbasisofeggcoatcrosslinkingshedslightonzp1associatedfemaleinfertility AT elisadioguardi molecularbasisofeggcoatcrosslinkingshedslightonzp1associatedfemaleinfertility AT shunsukenishio molecularbasisofeggcoatcrosslinkingshedslightonzp1associatedfemaleinfertility AT alessandravilla molecularbasisofeggcoatcrosslinkingshedslightonzp1associatedfemaleinfertility AT linghan molecularbasisofeggcoatcrosslinkingshedslightonzp1associatedfemaleinfertility AT tsukasamatsuda molecularbasisofeggcoatcrosslinkingshedslightonzp1associatedfemaleinfertility AT lucajovine molecularbasisofeggcoatcrosslinkingshedslightonzp1associatedfemaleinfertility
_version_	1718390531280601088

Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility

Ejemplares similares