Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver

Abstract Lifestyle-related diseases have become a major issue in recent years. The increasing incidence of fatty liver underlines the urgency with which the issues of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) need to be addressed. L-carnitine is a compound kn...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Koichi Fujisawa, Taro Takami, Aya Matsuzaki, Toshihiko Matsumoto, Naoki Yamamoto, Shuji Terai, Isao Sakaida
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56d754f1cc8f4367970dc3b3c98f3e0e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:56d754f1cc8f4367970dc3b3c98f3e0e
record_format	dspace
spelling	oai:doaj.org-article:56d754f1cc8f4367970dc3b3c98f3e0e2021-12-02T12:30:19ZEvaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver10.1038/s41598-017-02924-52045-2322https://doaj.org/article/56d754f1cc8f4367970dc3b3c98f3e0e2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02924-5https://doaj.org/toc/2045-2322Abstract Lifestyle-related diseases have become a major issue in recent years. The increasing incidence of fatty liver underlines the urgency with which the issues of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) need to be addressed. L-carnitine is a compound known to transport fatty acids into the mitochondria to enhance β-oxidation-mediated metabolism of fats. In this study, the effects of L-carnitine administration on fatty liver of medaka (Oryzias latipes) were analysed, to check for disease improvement and metabolic changes. Additionally, the effects of the concomitant administration of L-carnitine and eicosapentaenoic acid (20:5n-3) (EPA) were investigated. Findings indicated reduced lipid deposition, increase in metabolites associated with β-oxidation, and significant reduction in fatty acid levels in the liver, implying improvement in fatty liver condition. Concomitant administration of L-carnitine and EPA resulted in further benefits, via changes in fatty acid composition in the medaka fatty liver model.Koichi FujisawaTaro TakamiAya MatsuzakiToshihiko MatsumotoNaoki YamamotoShuji TeraiIsao SakaidaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Koichi Fujisawa Taro Takami Aya Matsuzaki Toshihiko Matsumoto Naoki Yamamoto Shuji Terai Isao Sakaida Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver
description	Abstract Lifestyle-related diseases have become a major issue in recent years. The increasing incidence of fatty liver underlines the urgency with which the issues of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) need to be addressed. L-carnitine is a compound known to transport fatty acids into the mitochondria to enhance β-oxidation-mediated metabolism of fats. In this study, the effects of L-carnitine administration on fatty liver of medaka (Oryzias latipes) were analysed, to check for disease improvement and metabolic changes. Additionally, the effects of the concomitant administration of L-carnitine and eicosapentaenoic acid (20:5n-3) (EPA) were investigated. Findings indicated reduced lipid deposition, increase in metabolites associated with β-oxidation, and significant reduction in fatty acid levels in the liver, implying improvement in fatty liver condition. Concomitant administration of L-carnitine and EPA resulted in further benefits, via changes in fatty acid composition in the medaka fatty liver model.
format	article
author	Koichi Fujisawa Taro Takami Aya Matsuzaki Toshihiko Matsumoto Naoki Yamamoto Shuji Terai Isao Sakaida
author_facet	Koichi Fujisawa Taro Takami Aya Matsuzaki Toshihiko Matsumoto Naoki Yamamoto Shuji Terai Isao Sakaida
author_sort	Koichi Fujisawa
title	Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver
title_short	Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver
title_full	Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver
title_fullStr	Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver
title_full_unstemmed	Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver
title_sort	evaluation of the effects of l-carnitine on medaka (oryzias latipes) fatty liver
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/56d754f1cc8f4367970dc3b3c98f3e0e
work_keys_str_mv	AT koichifujisawa evaluationoftheeffectsoflcarnitineonmedakaoryziaslatipesfattyliver AT tarotakami evaluationoftheeffectsoflcarnitineonmedakaoryziaslatipesfattyliver AT ayamatsuzaki evaluationoftheeffectsoflcarnitineonmedakaoryziaslatipesfattyliver AT toshihikomatsumoto evaluationoftheeffectsoflcarnitineonmedakaoryziaslatipesfattyliver AT naokiyamamoto evaluationoftheeffectsoflcarnitineonmedakaoryziaslatipesfattyliver AT shujiterai evaluationoftheeffectsoflcarnitineonmedakaoryziaslatipesfattyliver AT isaosakaida evaluationoftheeffectsoflcarnitineonmedakaoryziaslatipesfattyliver
_version_	1718394398660624384

Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver

Ejemplares similares