Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults.

<h4>Background</h4>Studies relating obesity to cognition in older people show conflicting results, which may be explained by the choice of obesity indicators.<h4>Objectives</h4>This study aimed to investigate the relationship between obesity-related indicators and cognitive i...

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Autores principales:	Weibo Ma, Hui Zhang, Ning Wu, Yuewen Liu, Peipei Han, Feng Wang, Jingru Wang, Fandi Xie, Shumeng Niu, Hao Hu, Chenyu Zhang, Nuo Chen, Yichen Zhang, Qi Guo, Ying Yu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56d7a0cd94bb4badb047e9baff0c7a1b
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spelling	oai:doaj.org-article:56d7a0cd94bb4badb047e9baff0c7a1b2021-12-02T20:13:27ZRelationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults.1932-620310.1371/journal.pone.0258922https://doaj.org/article/56d7a0cd94bb4badb047e9baff0c7a1b2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258922https://doaj.org/toc/1932-6203<h4>Background</h4>Studies relating obesity to cognition in older people show conflicting results, which may be explained by the choice of obesity indicators.<h4>Objectives</h4>This study aimed to investigate the relationship between obesity-related indicators and cognitive impairment, especially between different age or gender subgroups, and explore whether obesity-related indicators were related to specific cognitive domains.<h4>Methods</h4>This was a cross-sectional study on 1753 participants aged ≥ 60 years (41.0% men; aged 71.36 ± 5.96 years). Obesity-related indicators included body mass index (BMI), waist circumference (WC), calf circumference (CC), waist to hip ratio (WHR), waist to calf circumstance ratio (WCR), fat to fat-free mass ratio (FM/FFM). The Mini-Mental State Examination scale (MMSE) was used to assess cognitive function. Cognitive impairment was defined as a score ≤ 17 for illiterates, ≤ 20 for participants with primary school education, and ≤ 24 for those with junior high school degrees or above. Multiple logistic regression analysis was used to estimate multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were used to analyze and visualize the linear relationships.<h4>Results</h4>The prevalence of cognitive impairment was 18.77%. In the fully adjusted model, CC was negatively associated with cognitive impairment (OR = 0.94, 95% CI: 0.90-0.98). Further analysis showed that CC correlated positively with recall and place orientation. A higher FM/FFM was found to be associated with a higher prevalence of cognitive impairment (OR: 1.44, 95%CI: 0.88-2.35, P for trend = 0.029); this association was notable in women (P for trend = 0.002) and the oldest (P for trend = 0.009), and so did the potential effect of BMI on cognitive impairment (70-80 years: P for trend = 0.011; ≥ 80 years: P for trend = 0.013). No statistically significant association was found between cognitive impairment and WC, WHR, or WCR.<h4>Conclusion</h4>CC and FM/FFM were associated with cognitive impairment in older people. Future research needs to distinguish the effects of fat and muscle mass on cognitive function, with special attention to different ages and genders.Weibo MaHui ZhangNing WuYuewen LiuPeipei HanFeng WangJingru WangFandi XieShumeng NiuHao HuChenyu ZhangNuo ChenYichen ZhangQi GuoYing YuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258922 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Weibo Ma Hui Zhang Ning Wu Yuewen Liu Peipei Han Feng Wang Jingru Wang Fandi Xie Shumeng Niu Hao Hu Chenyu Zhang Nuo Chen Yichen Zhang Qi Guo Ying Yu Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults.
description	<h4>Background</h4>Studies relating obesity to cognition in older people show conflicting results, which may be explained by the choice of obesity indicators.<h4>Objectives</h4>This study aimed to investigate the relationship between obesity-related indicators and cognitive impairment, especially between different age or gender subgroups, and explore whether obesity-related indicators were related to specific cognitive domains.<h4>Methods</h4>This was a cross-sectional study on 1753 participants aged ≥ 60 years (41.0% men; aged 71.36 ± 5.96 years). Obesity-related indicators included body mass index (BMI), waist circumference (WC), calf circumference (CC), waist to hip ratio (WHR), waist to calf circumstance ratio (WCR), fat to fat-free mass ratio (FM/FFM). The Mini-Mental State Examination scale (MMSE) was used to assess cognitive function. Cognitive impairment was defined as a score ≤ 17 for illiterates, ≤ 20 for participants with primary school education, and ≤ 24 for those with junior high school degrees or above. Multiple logistic regression analysis was used to estimate multivariable-adjusted odds ratios (ORs) and 95% confidence intervals (CIs). Restricted cubic splines were used to analyze and visualize the linear relationships.<h4>Results</h4>The prevalence of cognitive impairment was 18.77%. In the fully adjusted model, CC was negatively associated with cognitive impairment (OR = 0.94, 95% CI: 0.90-0.98). Further analysis showed that CC correlated positively with recall and place orientation. A higher FM/FFM was found to be associated with a higher prevalence of cognitive impairment (OR: 1.44, 95%CI: 0.88-2.35, P for trend = 0.029); this association was notable in women (P for trend = 0.002) and the oldest (P for trend = 0.009), and so did the potential effect of BMI on cognitive impairment (70-80 years: P for trend = 0.011; ≥ 80 years: P for trend = 0.013). No statistically significant association was found between cognitive impairment and WC, WHR, or WCR.<h4>Conclusion</h4>CC and FM/FFM were associated with cognitive impairment in older people. Future research needs to distinguish the effects of fat and muscle mass on cognitive function, with special attention to different ages and genders.
format	article
author	Weibo Ma Hui Zhang Ning Wu Yuewen Liu Peipei Han Feng Wang Jingru Wang Fandi Xie Shumeng Niu Hao Hu Chenyu Zhang Nuo Chen Yichen Zhang Qi Guo Ying Yu
author_facet	Weibo Ma Hui Zhang Ning Wu Yuewen Liu Peipei Han Feng Wang Jingru Wang Fandi Xie Shumeng Niu Hao Hu Chenyu Zhang Nuo Chen Yichen Zhang Qi Guo Ying Yu
author_sort	Weibo Ma
title	Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults.
title_short	Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults.
title_full	Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults.
title_fullStr	Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults.
title_full_unstemmed	Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults.
title_sort	relationship between obesity-related anthropometric indicators and cognitive function in chinese suburb-dwelling older adults.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/56d7a0cd94bb4badb047e9baff0c7a1b
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Relationship between obesity-related anthropometric indicators and cognitive function in Chinese suburb-dwelling older adults.

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