Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice

CD47 is expressed on tumour cells and binds to SIRPα, expressed on myeloid cells, preventing phagocytosis. Here, the authors show that injection of tumour cells lacking CD47, or cells coated with an anti-CD47 antibody, into mice mounts a strong immune response, resulting in a reduction in tumour gro...

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Autores principales:	Yang Li, Mingyou Zhang, Xiaodan Wang, Wentao Liu, Hui Wang, Yong-Guang Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/56d87a81604e4ebd8d4ed35bb4517061
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spelling	oai:doaj.org-article:56d87a81604e4ebd8d4ed35bb45170612021-12-02T16:49:29ZVaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice10.1038/s41467-019-14102-42041-1723https://doaj.org/article/56d87a81604e4ebd8d4ed35bb45170612020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14102-4https://doaj.org/toc/2041-1723CD47 is expressed on tumour cells and binds to SIRPα, expressed on myeloid cells, preventing phagocytosis. Here, the authors show that injection of tumour cells lacking CD47, or cells coated with an anti-CD47 antibody, into mice mounts a strong immune response, resulting in a reduction in tumour growth.Yang LiMingyou ZhangXiaodan WangWentao LiuHui WangYong-Guang YangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yang Li Mingyou Zhang Xiaodan Wang Wentao Liu Hui Wang Yong-Guang Yang Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice
description	CD47 is expressed on tumour cells and binds to SIRPα, expressed on myeloid cells, preventing phagocytosis. Here, the authors show that injection of tumour cells lacking CD47, or cells coated with an anti-CD47 antibody, into mice mounts a strong immune response, resulting in a reduction in tumour growth.
format	article
author	Yang Li Mingyou Zhang Xiaodan Wang Wentao Liu Hui Wang Yong-Guang Yang
author_facet	Yang Li Mingyou Zhang Xiaodan Wang Wentao Liu Hui Wang Yong-Guang Yang
author_sort	Yang Li
title	Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice
title_short	Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice
title_full	Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice
title_fullStr	Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice
title_full_unstemmed	Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice
title_sort	vaccination with cd47 deficient tumor cells elicits an antitumor immune response in mice
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/56d87a81604e4ebd8d4ed35bb4517061
work_keys_str_mv	AT yangli vaccinationwithcd47deficienttumorcellselicitsanantitumorimmuneresponseinmice AT mingyouzhang vaccinationwithcd47deficienttumorcellselicitsanantitumorimmuneresponseinmice AT xiaodanwang vaccinationwithcd47deficienttumorcellselicitsanantitumorimmuneresponseinmice AT wentaoliu vaccinationwithcd47deficienttumorcellselicitsanantitumorimmuneresponseinmice AT huiwang vaccinationwithcd47deficienttumorcellselicitsanantitumorimmuneresponseinmice AT yongguangyang vaccinationwithcd47deficienttumorcellselicitsanantitumorimmuneresponseinmice
_version_	1718383278934720512

Vaccination with CD47 deficient tumor cells elicits an antitumor immune response in mice

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