Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction

Abstract Complex tissue regeneration is extremely rare among adult mammals. An exception, however, is the superior tissue healing of multiple organs in spiny mice (Acomys). While Acomys species exhibit the remarkable ability to heal complex tissue with minimal scarring, little is known about their c...

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Autores principales:	Hsuan Peng, Kazuhiro Shindo, Renée R. Donahue, Erhe Gao, Brooke M. Ahern, Bryana M. Levitan, Himi Tripathi, David Powell, Ahmed Noor, Garrett A. Elmore, Jonathan Satin, Ashley W. Seifert, Ahmed Abdel-Latif
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/56d8d1f810eb45b3a668916b5d668abb
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spelling	oai:doaj.org-article:56d8d1f810eb45b3a668916b5d668abb2021-11-21T12:40:28ZAdult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction10.1038/s41536-021-00186-42057-3995https://doaj.org/article/56d8d1f810eb45b3a668916b5d668abb2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00186-4https://doaj.org/toc/2057-3995Abstract Complex tissue regeneration is extremely rare among adult mammals. An exception, however, is the superior tissue healing of multiple organs in spiny mice (Acomys). While Acomys species exhibit the remarkable ability to heal complex tissue with minimal scarring, little is known about their cardiac structure and response to cardiac injury. In this study, we first examined baseline Acomys cardiac anatomy and function in comparison with commonly used inbred and outbred laboratory Mus strains (C57BL6 and CFW). While our results demonstrated comparable cardiac anatomy and function between Acomys and Mus, Acomys exhibited a higher percentage of cardiomyocytes displaying distinct characteristics. In response to myocardial infarction, all animals experienced a comparable level of initial cardiac damage. However, Acomys demonstrated superior ischemic tolerance and cytoprotection in response to injury as evidenced by cardiac functional stabilization, higher survival rate, and smaller scar size 50 days after injury compared to the inbred and outbred mouse strains. This phenomenon correlated with enhanced endothelial cell proliferation, increased angiogenesis, and medium vessel maturation in the peri-infarct and infarct regions. Overall, these findings demonstrate augmented myocardial preservation in spiny mice post-MI and establish Acomys as a new adult mammalian model for cardiac research.Hsuan PengKazuhiro ShindoRenée R. DonahueErhe GaoBrooke M. AhernBryana M. LevitanHimi TripathiDavid PowellAhmed NoorGarrett A. ElmoreJonathan SatinAshley W. SeifertAhmed Abdel-LatifNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Hsuan Peng Kazuhiro Shindo Renée R. Donahue Erhe Gao Brooke M. Ahern Bryana M. Levitan Himi Tripathi David Powell Ahmed Noor Garrett A. Elmore Jonathan Satin Ashley W. Seifert Ahmed Abdel-Latif Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction
description	Abstract Complex tissue regeneration is extremely rare among adult mammals. An exception, however, is the superior tissue healing of multiple organs in spiny mice (Acomys). While Acomys species exhibit the remarkable ability to heal complex tissue with minimal scarring, little is known about their cardiac structure and response to cardiac injury. In this study, we first examined baseline Acomys cardiac anatomy and function in comparison with commonly used inbred and outbred laboratory Mus strains (C57BL6 and CFW). While our results demonstrated comparable cardiac anatomy and function between Acomys and Mus, Acomys exhibited a higher percentage of cardiomyocytes displaying distinct characteristics. In response to myocardial infarction, all animals experienced a comparable level of initial cardiac damage. However, Acomys demonstrated superior ischemic tolerance and cytoprotection in response to injury as evidenced by cardiac functional stabilization, higher survival rate, and smaller scar size 50 days after injury compared to the inbred and outbred mouse strains. This phenomenon correlated with enhanced endothelial cell proliferation, increased angiogenesis, and medium vessel maturation in the peri-infarct and infarct regions. Overall, these findings demonstrate augmented myocardial preservation in spiny mice post-MI and establish Acomys as a new adult mammalian model for cardiac research.
format	article
author	Hsuan Peng Kazuhiro Shindo Renée R. Donahue Erhe Gao Brooke M. Ahern Bryana M. Levitan Himi Tripathi David Powell Ahmed Noor Garrett A. Elmore Jonathan Satin Ashley W. Seifert Ahmed Abdel-Latif
author_facet	Hsuan Peng Kazuhiro Shindo Renée R. Donahue Erhe Gao Brooke M. Ahern Bryana M. Levitan Himi Tripathi David Powell Ahmed Noor Garrett A. Elmore Jonathan Satin Ashley W. Seifert Ahmed Abdel-Latif
author_sort	Hsuan Peng
title	Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction
title_short	Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction
title_full	Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction
title_fullStr	Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction
title_full_unstemmed	Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction
title_sort	adult spiny mice (acomys) exhibit endogenous cardiac recovery in response to myocardial infarction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/56d8d1f810eb45b3a668916b5d668abb
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Adult spiny mice (Acomys) exhibit endogenous cardiac recovery in response to myocardial infarction

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