Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma

Naoko Aizawa, Yu Yokoyama, Naoki Chiba, Kazuko Omodaka, Masayuki Yasuda, Takaaki Otomo, Masahiko Nakamura, Nobuo Fuse, Toru NakazawaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine Sendai, Miyagi, JapanBackground: Laser speckle flowgraphy (LSFG) enables noninvasive quantifi...

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Autores principales:	Nakamura M, Otomo T, Yasuda M, Omodaka K, Chiba N, Yokoyama Y, Aizawa N, Fuse N, Nakazawa T
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/56d91ad9fb554b25943df9ad37650143
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spelling	oai:doaj.org-article:56d91ad9fb554b25943df9ad376501432021-12-02T04:54:08ZReproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma1177-54671177-5483https://doaj.org/article/56d91ad9fb554b25943df9ad376501432011-08-01T00:00:00Zhttp://www.dovepress.com/reproducibility-of-retinal-circulation-measurements-obtained-using-las-a8115https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Naoko Aizawa, Yu Yokoyama, Naoki Chiba, Kazuko Omodaka, Masayuki Yasuda, Takaaki Otomo, Masahiko Nakamura, Nobuo Fuse, Toru NakazawaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine Sendai, Miyagi, JapanBackground: Laser speckle flowgraphy (LSFG) enables noninvasive quantification of the retinal circulation in glaucoma patients. In this study, we tested the intrasession reproducibility of LSFG-NAVI, a modified LSFG technique.Methods: Sixty-five eyes from 33 subjects (male (M):female (F) = 17:16) with a mean age of 49.4 &plusmn; 11.2 years were examined in this study. Two parameters indicating reproducibility &ndash; the coefficient of variation (COV) and the intraclass correlation coefficient (ICC) &ndash; were analyzed three times on the same day that mean blur rate (MBR) was measured using LSFG-NAVI. The sites analyzed were the retinal artery and vein, the optic disk, and the choroid. Following classification according to the Glaucoma Hemifield Test (GHT; SITA-Standard 30-2 program), the COV and ICC were examined in patients with (GHT+; 38 eyes, M:F = 20:18, average age 48.9 &plusmn; 12.8 years) and without (GHT-; 27 eyes, M:F = 13:14, average age 50.1 &plusmn; 8.7 years) abnormal glaucomatous visual fields.Results: For all subjects, the intrasession reproducibility of MBR in the optic disk (COV: 3.4 &plusmn; 2.0; ICC: 0.95) and choroid (COV: 4.7 &plusmn; 3.4; ICC: 0.98) was excellent. The reproducibility for the retinal vein (COV: 8.4 &plusmn; 5.6, ICC: 0.90) and retinal artery (COV: 10.9 &plusmn; 9.9, ICC: 0.9) was moderate. MBRs in the optic disk had good reproducibility in both the GHT+ group (COV: 3.8 &plusmn; 2.0; ICC: 0.97) and the GHT&minus; group (COV: 2.9 &plusmn; 2.1; ICC: 0.95). Local assessment of the optic disk in normal or glaucoma patients showed that the COVs of the quadrant optic disk areas were best in the temporal area of MBR (3.4%, 4.2%, respectively).Conclusion: LSFG-NAVI showed favorable reproducibility in evaluation of retinal circulation of glaucoma patients, particularly in the optic disk and choroid.Keywords: ocular circulation, reproducibility, optic nerve, retinaNakamura MOtomo TYasuda MOmodaka KChiba NYokoyama YAizawa NFuse NNakazawa TDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2011, Iss default, Pp 1171-1176 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Nakamura M Otomo T Yasuda M Omodaka K Chiba N Yokoyama Y Aizawa N Fuse N Nakazawa T Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma
description	Naoko Aizawa, Yu Yokoyama, Naoki Chiba, Kazuko Omodaka, Masayuki Yasuda, Takaaki Otomo, Masahiko Nakamura, Nobuo Fuse, Toru NakazawaDepartment of Ophthalmology, Tohoku University Graduate School of Medicine Sendai, Miyagi, JapanBackground: Laser speckle flowgraphy (LSFG) enables noninvasive quantification of the retinal circulation in glaucoma patients. In this study, we tested the intrasession reproducibility of LSFG-NAVI, a modified LSFG technique.Methods: Sixty-five eyes from 33 subjects (male (M):female (F) = 17:16) with a mean age of 49.4 &plusmn; 11.2 years were examined in this study. Two parameters indicating reproducibility &ndash; the coefficient of variation (COV) and the intraclass correlation coefficient (ICC) &ndash; were analyzed three times on the same day that mean blur rate (MBR) was measured using LSFG-NAVI. The sites analyzed were the retinal artery and vein, the optic disk, and the choroid. Following classification according to the Glaucoma Hemifield Test (GHT; SITA-Standard 30-2 program), the COV and ICC were examined in patients with (GHT+; 38 eyes, M:F = 20:18, average age 48.9 &plusmn; 12.8 years) and without (GHT-; 27 eyes, M:F = 13:14, average age 50.1 &plusmn; 8.7 years) abnormal glaucomatous visual fields.Results: For all subjects, the intrasession reproducibility of MBR in the optic disk (COV: 3.4 &plusmn; 2.0; ICC: 0.95) and choroid (COV: 4.7 &plusmn; 3.4; ICC: 0.98) was excellent. The reproducibility for the retinal vein (COV: 8.4 &plusmn; 5.6, ICC: 0.90) and retinal artery (COV: 10.9 &plusmn; 9.9, ICC: 0.9) was moderate. MBRs in the optic disk had good reproducibility in both the GHT+ group (COV: 3.8 &plusmn; 2.0; ICC: 0.97) and the GHT&minus; group (COV: 2.9 &plusmn; 2.1; ICC: 0.95). Local assessment of the optic disk in normal or glaucoma patients showed that the COVs of the quadrant optic disk areas were best in the temporal area of MBR (3.4%, 4.2%, respectively).Conclusion: LSFG-NAVI showed favorable reproducibility in evaluation of retinal circulation of glaucoma patients, particularly in the optic disk and choroid.Keywords: ocular circulation, reproducibility, optic nerve, retina
format	article
author	Nakamura M Otomo T Yasuda M Omodaka K Chiba N Yokoyama Y Aizawa N Fuse N Nakazawa T
author_facet	Nakamura M Otomo T Yasuda M Omodaka K Chiba N Yokoyama Y Aizawa N Fuse N Nakazawa T
author_sort	Nakamura M
title	Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma
title_short	Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma
title_full	Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma
title_fullStr	Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma
title_full_unstemmed	Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma
title_sort	reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-navi in patients with glaucoma
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/56d91ad9fb554b25943df9ad37650143
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Reproducibility of retinal circulation measurements obtained using laser speckle flowgraphy-NAVI in patients with glaucoma

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