ST-segment elevation myocardial infarction with non-obstructive coronary arteries: Score derivation for prediction based on a large national registry.

<h4>Background</h4>Acute myocardial infarction with ST-segment elevation (STEMI) and obstructive coronary arteries (MI-CAD) are treated with primary percutaneous coronary interventions (pPCI), while patients with STEMI and non-obstructive coronary arteries (MINOCA), usually require non-i...

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Autores principales:	Magdalena Jędrychowska, Zbigniew Siudak, Krzysztof Piotr Malinowski, Łukasz Zandecki, Michał Zabojszcz, Tomasz Kameczura, Piotr Mika, Krzysztof Bartuś, Wojciech Wańha, Wojciech Wojakowski, Jacek Legutko, Stanisław Bartuś, Rafał Januszek
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56dd63ac87544993ad71975e651ae65a
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spelling	oai:doaj.org-article:56dd63ac87544993ad71975e651ae65a2021-12-02T20:18:42ZST-segment elevation myocardial infarction with non-obstructive coronary arteries: Score derivation for prediction based on a large national registry.1932-620310.1371/journal.pone.0254427https://doaj.org/article/56dd63ac87544993ad71975e651ae65a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254427https://doaj.org/toc/1932-6203<h4>Background</h4>Acute myocardial infarction with ST-segment elevation (STEMI) and obstructive coronary arteries (MI-CAD) are treated with primary percutaneous coronary interventions (pPCI), while patients with STEMI and non-obstructive coronary arteries (MINOCA), usually require non-invasive therapy. The aim of the study is to design a score for predicting suspected MINOCA among an overall group of STEMI patients.<h4>Materials and methods</h4>Based on the Polish national registry of PCIs, we evaluated patients between 2014 and 2019, and selected 526,490 subjects treated with PCI and 650,728 treated using only coronary angiography. These subjects were chosen out of 1,177,218 patients who underwent coronary angiography. Then, we selected 124,663 individuals treated with pPCI due to STEMI and 5,695 patients with STEMI and MINOCA. The score for suspected MINOCA was created using the regression model, while the coefficients calculated for the final model were used to construct a predictive model in the form of a nomogram.<h4>Results</h4>Patients with MINOCA differ significantly from those in the MI-CAD group; they were significantly younger, less often males and demonstrated smaller burden of concomitant diseases. The model allowed to show that patients who scored more than 600 points had a 19% probability of MINOCA, while for those scoring more than 650 points, the likelihood was 71%. The other end of the MINOCA probability scale was marginal for patients who scored less than 500 points (< .2%).<h4>Conclusions</h4>Based on the created MINOCA score presented in the current publication, we are able to distinguish MINOCA from MI-CAD patients in the STEMI group.Magdalena JędrychowskaZbigniew SiudakKrzysztof Piotr MalinowskiŁukasz ZandeckiMichał ZabojszczTomasz KameczuraPiotr MikaKrzysztof BartuśWojciech WańhaWojciech WojakowskiJacek LegutkoStanisław BartuśRafał JanuszekPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0254427 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Magdalena Jędrychowska Zbigniew Siudak Krzysztof Piotr Malinowski Łukasz Zandecki Michał Zabojszcz Tomasz Kameczura Piotr Mika Krzysztof Bartuś Wojciech Wańha Wojciech Wojakowski Jacek Legutko Stanisław Bartuś Rafał Januszek ST-segment elevation myocardial infarction with non-obstructive coronary arteries: Score derivation for prediction based on a large national registry.
description	<h4>Background</h4>Acute myocardial infarction with ST-segment elevation (STEMI) and obstructive coronary arteries (MI-CAD) are treated with primary percutaneous coronary interventions (pPCI), while patients with STEMI and non-obstructive coronary arteries (MINOCA), usually require non-invasive therapy. The aim of the study is to design a score for predicting suspected MINOCA among an overall group of STEMI patients.<h4>Materials and methods</h4>Based on the Polish national registry of PCIs, we evaluated patients between 2014 and 2019, and selected 526,490 subjects treated with PCI and 650,728 treated using only coronary angiography. These subjects were chosen out of 1,177,218 patients who underwent coronary angiography. Then, we selected 124,663 individuals treated with pPCI due to STEMI and 5,695 patients with STEMI and MINOCA. The score for suspected MINOCA was created using the regression model, while the coefficients calculated for the final model were used to construct a predictive model in the form of a nomogram.<h4>Results</h4>Patients with MINOCA differ significantly from those in the MI-CAD group; they were significantly younger, less often males and demonstrated smaller burden of concomitant diseases. The model allowed to show that patients who scored more than 600 points had a 19% probability of MINOCA, while for those scoring more than 650 points, the likelihood was 71%. The other end of the MINOCA probability scale was marginal for patients who scored less than 500 points (< .2%).<h4>Conclusions</h4>Based on the created MINOCA score presented in the current publication, we are able to distinguish MINOCA from MI-CAD patients in the STEMI group.
format	article
author	Magdalena Jędrychowska Zbigniew Siudak Krzysztof Piotr Malinowski Łukasz Zandecki Michał Zabojszcz Tomasz Kameczura Piotr Mika Krzysztof Bartuś Wojciech Wańha Wojciech Wojakowski Jacek Legutko Stanisław Bartuś Rafał Januszek
author_facet	Magdalena Jędrychowska Zbigniew Siudak Krzysztof Piotr Malinowski Łukasz Zandecki Michał Zabojszcz Tomasz Kameczura Piotr Mika Krzysztof Bartuś Wojciech Wańha Wojciech Wojakowski Jacek Legutko Stanisław Bartuś Rafał Januszek
author_sort	Magdalena Jędrychowska
title	ST-segment elevation myocardial infarction with non-obstructive coronary arteries: Score derivation for prediction based on a large national registry.
title_short	ST-segment elevation myocardial infarction with non-obstructive coronary arteries: Score derivation for prediction based on a large national registry.
title_full	ST-segment elevation myocardial infarction with non-obstructive coronary arteries: Score derivation for prediction based on a large national registry.
title_fullStr	ST-segment elevation myocardial infarction with non-obstructive coronary arteries: Score derivation for prediction based on a large national registry.
title_full_unstemmed	ST-segment elevation myocardial infarction with non-obstructive coronary arteries: Score derivation for prediction based on a large national registry.
title_sort	st-segment elevation myocardial infarction with non-obstructive coronary arteries: score derivation for prediction based on a large national registry.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/56dd63ac87544993ad71975e651ae65a
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ST-segment elevation myocardial infarction with non-obstructive coronary arteries: Score derivation for prediction based on a large national registry.

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