Methylation of the RIN3 Promoter is Associated with Transient Ischemic Stroke/Mild Ischemic Stroke with Early Cognitive Impairment

Meng Miao,1 Fang Yuan,2 Xiaotian Ma,3 Haiming Yang,1 Xiang Gao,1 Zhengyu Zhu,4 Jianzhong Bi4 1Department of Neurology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, 266035, People’s Republic of China; 2Department of Health Care, Qilu Hospital (Qingdao)...

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Autores principales:	Miao M, Yuan F, Ma X, Yang H, Gao X, Zhu Z, Bi J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	amyloid β-protein cognitive impairment hypomethylation ischemic stroke transportation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/56e1e568484143e0a240d878ea917f63
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spelling	oai:doaj.org-article:56e1e568484143e0a240d878ea917f632021-12-02T17:07:18ZMethylation of the RIN3 Promoter is Associated with Transient Ischemic Stroke/Mild Ischemic Stroke with Early Cognitive Impairment1178-2021https://doaj.org/article/56e1e568484143e0a240d878ea917f632021-08-01T00:00:00Zhttps://www.dovepress.com/methylation-of-the-rin3-promoter-is-associated-with-transient-ischemic-peer-reviewed-fulltext-article-NDThttps://doaj.org/toc/1178-2021Meng Miao,1 Fang Yuan,2 Xiaotian Ma,3 Haiming Yang,1 Xiang Gao,1 Zhengyu Zhu,4 Jianzhong Bi4 1Department of Neurology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, 266035, People’s Republic of China; 2Department of Health Care, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, 266035, People’s Republic of China; 3Department of Medicine Experimental Center, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, 266035, People’s Republic of China; 4Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, People’s Republic of ChinaCorrespondence: Zhengyu Zhu; Jianzhong BiDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, People’s Republic of ChinaTel +8617660083488; +8615153178111Email zhuzhengyu_1@hotmail.com; bjz@sdu.edu.cnBackground: Early cognitive impairment after transient ischemic stroke (TIA)/mild ischemic stroke (MIS) is common but easily overlooked. It has been demonstrated that DNA methylation plays a significant role in cognitive impairment and ischemic stroke. Furthermore, it has been reported that the RIN3 gene influences transportation of the amyloid β-protein. However, to our knowledge, there has been no research related to correlations between RIN3 methylation and early-onset cognitive impairment after TIA/MIS. Therefore, this study aimed to investigate this relationship in TIA/MIS patients.Methods: This study include 28 control subjects and 84 patients with TIA/MIS who were evaluated within 7 days of TIA/MIS onset using four single-domain cognitive scales. In addition, DNA methylation of whole blood was tested. RIN3 methylation was compared between TIA/MIS and control groups and between TIA/MIS patients with early cognitive impairment and those without early cognitive impairment. Clinical variables and RIN3 methylation sites with statistical differences were then used to construct a predictive model.Results: Hypomethylation of the RIN3 gene was observed in the whole blood of TIA/MIS patients relative to healthy controls. Furthermore, patients with early cognitive impairment after TIA/MIS had hypomethylation of RIN3 relative to those without early cognitive impairment.Conclusion: RIN3 methylation is strongly associated with TIA/MIS and TIA/MIS with early cognitive impairment. It is possible to influence the disease process by methylation via appropriate lifestyle and clinical interventions, and methylation of RIN3 gene sites may predict the occurrence of TIA/MIS with early cognitive impairment.Keywords: amyloid &Bgr;-protein, cognitive impairment, hypomethylation, ischemic stroke, transportationMiao MYuan FMa XYang HGao XZhu ZBi JDove Medical Pressarticleamyloid β-proteincognitive impairmenthypomethylationischemic stroketransportationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 17, Pp 2587-2598 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	amyloid β-protein cognitive impairment hypomethylation ischemic stroke transportation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	amyloid β-protein cognitive impairment hypomethylation ischemic stroke transportation Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Miao M Yuan F Ma X Yang H Gao X Zhu Z Bi J Methylation of the RIN3 Promoter is Associated with Transient Ischemic Stroke/Mild Ischemic Stroke with Early Cognitive Impairment
description	Meng Miao,1 Fang Yuan,2 Xiaotian Ma,3 Haiming Yang,1 Xiang Gao,1 Zhengyu Zhu,4 Jianzhong Bi4 1Department of Neurology, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, 266035, People’s Republic of China; 2Department of Health Care, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, 266035, People’s Republic of China; 3Department of Medicine Experimental Center, Qilu Hospital (Qingdao), Cheeloo College of Medicine, Shandong University, Qingdao, Shandong, 266035, People’s Republic of China; 4Department of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, People’s Republic of ChinaCorrespondence: Zhengyu Zhu; Jianzhong BiDepartment of Neurology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, People’s Republic of ChinaTel +8617660083488; +8615153178111Email zhuzhengyu_1@hotmail.com; bjz@sdu.edu.cnBackground: Early cognitive impairment after transient ischemic stroke (TIA)/mild ischemic stroke (MIS) is common but easily overlooked. It has been demonstrated that DNA methylation plays a significant role in cognitive impairment and ischemic stroke. Furthermore, it has been reported that the RIN3 gene influences transportation of the amyloid β-protein. However, to our knowledge, there has been no research related to correlations between RIN3 methylation and early-onset cognitive impairment after TIA/MIS. Therefore, this study aimed to investigate this relationship in TIA/MIS patients.Methods: This study include 28 control subjects and 84 patients with TIA/MIS who were evaluated within 7 days of TIA/MIS onset using four single-domain cognitive scales. In addition, DNA methylation of whole blood was tested. RIN3 methylation was compared between TIA/MIS and control groups and between TIA/MIS patients with early cognitive impairment and those without early cognitive impairment. Clinical variables and RIN3 methylation sites with statistical differences were then used to construct a predictive model.Results: Hypomethylation of the RIN3 gene was observed in the whole blood of TIA/MIS patients relative to healthy controls. Furthermore, patients with early cognitive impairment after TIA/MIS had hypomethylation of RIN3 relative to those without early cognitive impairment.Conclusion: RIN3 methylation is strongly associated with TIA/MIS and TIA/MIS with early cognitive impairment. It is possible to influence the disease process by methylation via appropriate lifestyle and clinical interventions, and methylation of RIN3 gene sites may predict the occurrence of TIA/MIS with early cognitive impairment.Keywords: amyloid &Bgr;-protein, cognitive impairment, hypomethylation, ischemic stroke, transportation
format	article
author	Miao M Yuan F Ma X Yang H Gao X Zhu Z Bi J
author_facet	Miao M Yuan F Ma X Yang H Gao X Zhu Z Bi J
author_sort	Miao M
title	Methylation of the RIN3 Promoter is Associated with Transient Ischemic Stroke/Mild Ischemic Stroke with Early Cognitive Impairment
title_short	Methylation of the RIN3 Promoter is Associated with Transient Ischemic Stroke/Mild Ischemic Stroke with Early Cognitive Impairment
title_full	Methylation of the RIN3 Promoter is Associated with Transient Ischemic Stroke/Mild Ischemic Stroke with Early Cognitive Impairment
title_fullStr	Methylation of the RIN3 Promoter is Associated with Transient Ischemic Stroke/Mild Ischemic Stroke with Early Cognitive Impairment
title_full_unstemmed	Methylation of the RIN3 Promoter is Associated with Transient Ischemic Stroke/Mild Ischemic Stroke with Early Cognitive Impairment
title_sort	methylation of the rin3 promoter is associated with transient ischemic stroke/mild ischemic stroke with early cognitive impairment
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/56e1e568484143e0a240d878ea917f63
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Methylation of the RIN3 Promoter is Associated with Transient Ischemic Stroke/Mild Ischemic Stroke with Early Cognitive Impairment

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