Low uric acid is a risk factor in mild cognitive impairment

LingLing Xue, YongBing Liu, HuiPing Xue, Jin Xue, KaiXuan Sun, LinFeng Wu, Ping Hou School of Nursing, YangZhou University, Yangzhou City, China Background: Mild cognitive impairment (MCI) represents a transitional stage between normal aging and dementia. Uric acid is a water-soluble antioxidant f...

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Autores principales:	Xue L, Liu Y, Xue H, Xue J, Sun K, Wu L, Hou P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Mild cognitive impairment uric acid relationship Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/56e2656706794c719a4c9f48a9569517
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spelling	oai:doaj.org-article:56e2656706794c719a4c9f48a95695172021-12-02T04:39:20ZLow uric acid is a risk factor in mild cognitive impairment1178-2021https://doaj.org/article/56e2656706794c719a4c9f48a95695172017-09-01T00:00:00Zhttps://www.dovepress.com/low-uric-acid-is-a-risk-factor-in-mild-cognitive-impairment-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021LingLing Xue, YongBing Liu, HuiPing Xue, Jin Xue, KaiXuan Sun, LinFeng Wu, Ping Hou School of Nursing, YangZhou University, Yangzhou City, China Background: Mild cognitive impairment (MCI) represents a transitional stage between normal aging and dementia. Uric acid is a water-soluble antioxidant found in the body. Many recent studies have found that uric acid plays an important role in cognitive impairment, although the effects of uric acid on MCI are not clear.Objective: The objective of this study was to explore the relationship between uric acid and MCI. Methods: Using a random sampling method, this study investigated 58 patients with MCI and 57 healthy elderly from January 2016 to November 2016. Demographic information was collected, the subjects were evaluated using the Mini Mental Status Examination (MMSE), and uric acid was measured in fasting venous blood.Results: A total of 57 (49.6%) participants are healthy and 58 (50.4%) participants had MCI. The uric acid level was significantly lower in the patients with MCI (292.28±63.71 µmol/L) than in the normal controls (322.49±78.70 µmol/L; P<0.05). There were significant positive correlations between the MMSE scores, for each dimension and the total score, and uric acid level (all P<0.05). Multivariate logistic regression models illustrated that uric acid was a protective factor for MCI (odds ratio =0.999, 95% CI =0.987–0.999).Conclusion: A low uric acid level is a risk factor for MCI, and an appropriate increase in uric acid can be used to slow down the occurrence and development of MCI. Keywords: mild cognitive impairment, uric acid, relationshipXue LLiu YXue HXue JSun KWu LHou PDove Medical PressarticleMild cognitive impairmenturic acidrelationshipNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2363-2367 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mild cognitive impairment uric acid relationship Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Mild cognitive impairment uric acid relationship Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Xue L Liu Y Xue H Xue J Sun K Wu L Hou P Low uric acid is a risk factor in mild cognitive impairment
description	LingLing Xue, YongBing Liu, HuiPing Xue, Jin Xue, KaiXuan Sun, LinFeng Wu, Ping Hou School of Nursing, YangZhou University, Yangzhou City, China Background: Mild cognitive impairment (MCI) represents a transitional stage between normal aging and dementia. Uric acid is a water-soluble antioxidant found in the body. Many recent studies have found that uric acid plays an important role in cognitive impairment, although the effects of uric acid on MCI are not clear.Objective: The objective of this study was to explore the relationship between uric acid and MCI. Methods: Using a random sampling method, this study investigated 58 patients with MCI and 57 healthy elderly from January 2016 to November 2016. Demographic information was collected, the subjects were evaluated using the Mini Mental Status Examination (MMSE), and uric acid was measured in fasting venous blood.Results: A total of 57 (49.6%) participants are healthy and 58 (50.4%) participants had MCI. The uric acid level was significantly lower in the patients with MCI (292.28±63.71 µmol/L) than in the normal controls (322.49±78.70 µmol/L; P<0.05). There were significant positive correlations between the MMSE scores, for each dimension and the total score, and uric acid level (all P<0.05). Multivariate logistic regression models illustrated that uric acid was a protective factor for MCI (odds ratio =0.999, 95% CI =0.987–0.999).Conclusion: A low uric acid level is a risk factor for MCI, and an appropriate increase in uric acid can be used to slow down the occurrence and development of MCI. Keywords: mild cognitive impairment, uric acid, relationship
format	article
author	Xue L Liu Y Xue H Xue J Sun K Wu L Hou P
author_facet	Xue L Liu Y Xue H Xue J Sun K Wu L Hou P
author_sort	Xue L
title	Low uric acid is a risk factor in mild cognitive impairment
title_short	Low uric acid is a risk factor in mild cognitive impairment
title_full	Low uric acid is a risk factor in mild cognitive impairment
title_fullStr	Low uric acid is a risk factor in mild cognitive impairment
title_full_unstemmed	Low uric acid is a risk factor in mild cognitive impairment
title_sort	low uric acid is a risk factor in mild cognitive impairment
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/56e2656706794c719a4c9f48a9569517
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_version_	1718401120999571456

Low uric acid is a risk factor in mild cognitive impairment

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