Cytomegalovirus Infection in Infancy May Increase the Risk of Subsequent Epilepsy and Autism Spectrum Disorder in Childhood

Cytomegalovirus (CMV) is a ubiquitous virus, and CMV-associated diseases range from mild illness in immunologically normal hosts to life-threatening diseases in newborns and immunocompromised children. This study investigated the association between childhood CMV infection and subsequent epilepsy or...

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Autores principales:	Chien-Heng Lin, I.-Ching Chou, Inn-Chi Lee, Syuan-Yu Hong
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	CMV infections epilepsy infancy attention deficit hyperactivity disorder autism spectrum disorder Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/56e6e3a1fa314354bc68293cdc3e9471
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spelling	oai:doaj.org-article:56e6e3a1fa314354bc68293cdc3e94712021-11-25T17:14:45ZCytomegalovirus Infection in Infancy May Increase the Risk of Subsequent Epilepsy and Autism Spectrum Disorder in Childhood10.3390/children81110402227-9067https://doaj.org/article/56e6e3a1fa314354bc68293cdc3e94712021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9067/8/11/1040https://doaj.org/toc/2227-9067Cytomegalovirus (CMV) is a ubiquitous virus, and CMV-associated diseases range from mild illness in immunologically normal hosts to life-threatening diseases in newborns and immunocompromised children. This study investigated the association between childhood CMV infection and subsequent epilepsy or neurodevelopmental disorders, attention deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD). A retrospective analysis was performed on data for 69 children with confirmed CMV infections (CMV infection group) and 292 patients with other infections (control group) between 1 January 2006 to 31 December 2012. The results indicated that the CMV infection group had a higher risk of epilepsy in comparison to the control (odds ratio (OR), 16.4; 95% CI (confidence interval), 3.32–80.7; <i>p</i> = 0.001). Epilepsy risk increased in younger children (age 0–2) with CMV infection when compared to the control group (OR, 32.6; 95% CI, 3.84–276; <i>p</i> = 0.001). The ASD risk was also determined to be higher in the CMV infection group (OR, 17.9; 95% CI, 1.96–162; <i>p</i> = 0.01). The ADHD risk between the groups was not significant. This study suggests that CMV infection in infancy may increase the risk of subsequent epilepsy and ASD, especially in infants younger than 2 years, but is not associated with ADHD.Chien-Heng LinI.-Ching ChouInn-Chi LeeSyuan-Yu HongMDPI AGarticleCMV infectionsepilepsyinfancyattention deficit hyperactivity disorderautism spectrum disorderPediatricsRJ1-570ENChildren, Vol 8, Iss 1040, p 1040 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	CMV infections epilepsy infancy attention deficit hyperactivity disorder autism spectrum disorder Pediatrics RJ1-570
spellingShingle	CMV infections epilepsy infancy attention deficit hyperactivity disorder autism spectrum disorder Pediatrics RJ1-570 Chien-Heng Lin I.-Ching Chou Inn-Chi Lee Syuan-Yu Hong Cytomegalovirus Infection in Infancy May Increase the Risk of Subsequent Epilepsy and Autism Spectrum Disorder in Childhood
description	Cytomegalovirus (CMV) is a ubiquitous virus, and CMV-associated diseases range from mild illness in immunologically normal hosts to life-threatening diseases in newborns and immunocompromised children. This study investigated the association between childhood CMV infection and subsequent epilepsy or neurodevelopmental disorders, attention deficit hyperactivity disorder (ADHD), and autism spectrum disorder (ASD). A retrospective analysis was performed on data for 69 children with confirmed CMV infections (CMV infection group) and 292 patients with other infections (control group) between 1 January 2006 to 31 December 2012. The results indicated that the CMV infection group had a higher risk of epilepsy in comparison to the control (odds ratio (OR), 16.4; 95% CI (confidence interval), 3.32–80.7; <i>p</i> = 0.001). Epilepsy risk increased in younger children (age 0–2) with CMV infection when compared to the control group (OR, 32.6; 95% CI, 3.84–276; <i>p</i> = 0.001). The ASD risk was also determined to be higher in the CMV infection group (OR, 17.9; 95% CI, 1.96–162; <i>p</i> = 0.01). The ADHD risk between the groups was not significant. This study suggests that CMV infection in infancy may increase the risk of subsequent epilepsy and ASD, especially in infants younger than 2 years, but is not associated with ADHD.
format	article
author	Chien-Heng Lin I.-Ching Chou Inn-Chi Lee Syuan-Yu Hong
author_facet	Chien-Heng Lin I.-Ching Chou Inn-Chi Lee Syuan-Yu Hong
author_sort	Chien-Heng Lin
title	Cytomegalovirus Infection in Infancy May Increase the Risk of Subsequent Epilepsy and Autism Spectrum Disorder in Childhood
title_short	Cytomegalovirus Infection in Infancy May Increase the Risk of Subsequent Epilepsy and Autism Spectrum Disorder in Childhood
title_full	Cytomegalovirus Infection in Infancy May Increase the Risk of Subsequent Epilepsy and Autism Spectrum Disorder in Childhood
title_fullStr	Cytomegalovirus Infection in Infancy May Increase the Risk of Subsequent Epilepsy and Autism Spectrum Disorder in Childhood
title_full_unstemmed	Cytomegalovirus Infection in Infancy May Increase the Risk of Subsequent Epilepsy and Autism Spectrum Disorder in Childhood
title_sort	cytomegalovirus infection in infancy may increase the risk of subsequent epilepsy and autism spectrum disorder in childhood
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/56e6e3a1fa314354bc68293cdc3e9471
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Cytomegalovirus Infection in Infancy May Increase the Risk of Subsequent Epilepsy and Autism Spectrum Disorder in Childhood

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