Immune dysregulation in patients with carpal tunnel syndrome

Abstract Peripheral immunity plays a key role in maintaining homeostasis and conferring crucial neuroprotective effects on the injured nervous system, while at the same time may contribute to increased vulnerability to neuropathic pain. Little is known about the reciprocal relationship between entra...

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Autores principales:	Gila Moalem-Taylor, Benny Baharuddin, Barbara Bennett, Arun V. Krishnan, William Huynh, Matthew C. Kiernan, Cindy Shin-Yi Lin, Boaz Shulruf, Elizabeth Keoshkerian, Barbara Cameron, Andrew Lloyd
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56e89824e3ff4b999fba9cf48b78ca86
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spelling	oai:doaj.org-article:56e89824e3ff4b999fba9cf48b78ca862021-12-02T16:06:51ZImmune dysregulation in patients with carpal tunnel syndrome10.1038/s41598-017-08123-62045-2322https://doaj.org/article/56e89824e3ff4b999fba9cf48b78ca862017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08123-6https://doaj.org/toc/2045-2322Abstract Peripheral immunity plays a key role in maintaining homeostasis and conferring crucial neuroprotective effects on the injured nervous system, while at the same time may contribute to increased vulnerability to neuropathic pain. Little is known about the reciprocal relationship between entrapment neuropathy and peripheral immunity. This study investigated immune profile in patients with carpal tunnel syndrome (CTS), the most prevalent entrapment neuropathy. All patients exhibited neurophysiological abnormalities in the median nerve, with the majority reporting neuropathic pain symptoms. We found a significant increase in serum CCL5, CXCL8, CXCL10 and VEGF, and in CD4+ central and effector memory T cells in CTS patients, as compared to healthy controls. CCL5 and VEGF were identified as having the highest power to discriminate between patients and controls. Interestingly, and contrary to the prevailing view of CCL5 as a pro-nociceptive factor, the level of circulating CCL5 was inversely correlated with neuropathic pain intensity and median nerve motor latency. In contrast, the level of central memory T cells was positively associated with abnormal neurophysiological findings. These results suggest that entrapment neuropathy is associated with adaptive changes in the homeostasis of memory T cells and an increase in systemic inflammatory modulating cytokines/chemokines, which potentially regulate neuropathic symptoms.Gila Moalem-TaylorBenny BaharuddinBarbara BennettArun V. KrishnanWilliam HuynhMatthew C. KiernanCindy Shin-Yi LinBoaz ShulrufElizabeth KeoshkerianBarbara CameronAndrew LloydNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gila Moalem-Taylor Benny Baharuddin Barbara Bennett Arun V. Krishnan William Huynh Matthew C. Kiernan Cindy Shin-Yi Lin Boaz Shulruf Elizabeth Keoshkerian Barbara Cameron Andrew Lloyd Immune dysregulation in patients with carpal tunnel syndrome
description	Abstract Peripheral immunity plays a key role in maintaining homeostasis and conferring crucial neuroprotective effects on the injured nervous system, while at the same time may contribute to increased vulnerability to neuropathic pain. Little is known about the reciprocal relationship between entrapment neuropathy and peripheral immunity. This study investigated immune profile in patients with carpal tunnel syndrome (CTS), the most prevalent entrapment neuropathy. All patients exhibited neurophysiological abnormalities in the median nerve, with the majority reporting neuropathic pain symptoms. We found a significant increase in serum CCL5, CXCL8, CXCL10 and VEGF, and in CD4+ central and effector memory T cells in CTS patients, as compared to healthy controls. CCL5 and VEGF were identified as having the highest power to discriminate between patients and controls. Interestingly, and contrary to the prevailing view of CCL5 as a pro-nociceptive factor, the level of circulating CCL5 was inversely correlated with neuropathic pain intensity and median nerve motor latency. In contrast, the level of central memory T cells was positively associated with abnormal neurophysiological findings. These results suggest that entrapment neuropathy is associated with adaptive changes in the homeostasis of memory T cells and an increase in systemic inflammatory modulating cytokines/chemokines, which potentially regulate neuropathic symptoms.
format	article
author	Gila Moalem-Taylor Benny Baharuddin Barbara Bennett Arun V. Krishnan William Huynh Matthew C. Kiernan Cindy Shin-Yi Lin Boaz Shulruf Elizabeth Keoshkerian Barbara Cameron Andrew Lloyd
author_facet	Gila Moalem-Taylor Benny Baharuddin Barbara Bennett Arun V. Krishnan William Huynh Matthew C. Kiernan Cindy Shin-Yi Lin Boaz Shulruf Elizabeth Keoshkerian Barbara Cameron Andrew Lloyd
author_sort	Gila Moalem-Taylor
title	Immune dysregulation in patients with carpal tunnel syndrome
title_short	Immune dysregulation in patients with carpal tunnel syndrome
title_full	Immune dysregulation in patients with carpal tunnel syndrome
title_fullStr	Immune dysregulation in patients with carpal tunnel syndrome
title_full_unstemmed	Immune dysregulation in patients with carpal tunnel syndrome
title_sort	immune dysregulation in patients with carpal tunnel syndrome
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/56e89824e3ff4b999fba9cf48b78ca86
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Immune dysregulation in patients with carpal tunnel syndrome

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