Dietary glycemic index during pregnancy is associated with biomarkers of the metabolic syndrome in offspring at age 20 years.

<h4>Objective</h4>Growing evidence indicates that metabolic syndrome is rooted in fetal life with a potential key role of nutrition during pregnancy. The objective of the study was to assess the possible associations between the dietary glycemic index (GI) and glycemic load (GL) during p...

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Autores principales:	Inge Danielsen, Charlotta Granström, Thorhallur Haldorsson, Dorte Rytter, Bodil Hammer Bech, Tine Brink Henriksen, Allan Arthur Vaag, Sjurdur Frodi Olsen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56eaa2d1c65043e99623353f9697e7bf
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spelling	oai:doaj.org-article:56eaa2d1c65043e99623353f9697e7bf2021-11-18T07:43:32ZDietary glycemic index during pregnancy is associated with biomarkers of the metabolic syndrome in offspring at age 20 years.1932-620310.1371/journal.pone.0064887https://doaj.org/article/56eaa2d1c65043e99623353f9697e7bf2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23741411/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Growing evidence indicates that metabolic syndrome is rooted in fetal life with a potential key role of nutrition during pregnancy. The objective of the study was to assess the possible associations between the dietary glycemic index (GI) and glycemic load (GL) during pregnancy and biomarkers of the metabolic syndrome in young adult offspring.<h4>Methods</h4>Dietary GI and GL were assessed by questionnaires and interviews in gestation week 30 and offspring were clinically examined at the age of 20 years. Analyses based on 428 mother-offspring dyads were adjusted for maternal smoking during pregnancy, height, pre-pregnancy body mass index (BMI), education, energy intake, and the offspring's ambient level of physical activity. In addition, possible confounding by gestational diabetes mellitus was taken into account.<h4>Outcome measures</h4>Waist circumference, blood pressure, HOMA insulin resistance (HOMA-IR) and plasma levels of fasting glucose, triglycerides, HDL cholesterol, LDL cholesterol, total cholesterol, insulin, and leptin were measured in the offspring.<h4>Results</h4>Significant associations were found between dietary GI in pregnancy and HOMA-IR (the relative increase in HOMA-IR per 10 units' GI increase was 1.09 [95% CI: 1.01, 1.16], p = 0.02), insulin (1.09 [95% CI: 1.02, 1.16], p = 0.01) and leptin (1.21 [95% CI: 1.06, 1.38], p = 0.01) in the offspring; whereas no associations were detected for GL.<h4>Conclusions</h4>Our data suggests that high dietary GI in pregnancy may affect levels of markers for the metabolic syndrome in young adult offspring in a potentially harmful direction.Inge DanielsenCharlotta GranströmThorhallur HaldorssonDorte RytterBodil Hammer BechTine Brink HenriksenAllan Arthur VaagSjurdur Frodi OlsenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e64887 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Inge Danielsen Charlotta Granström Thorhallur Haldorsson Dorte Rytter Bodil Hammer Bech Tine Brink Henriksen Allan Arthur Vaag Sjurdur Frodi Olsen Dietary glycemic index during pregnancy is associated with biomarkers of the metabolic syndrome in offspring at age 20 years.
description	<h4>Objective</h4>Growing evidence indicates that metabolic syndrome is rooted in fetal life with a potential key role of nutrition during pregnancy. The objective of the study was to assess the possible associations between the dietary glycemic index (GI) and glycemic load (GL) during pregnancy and biomarkers of the metabolic syndrome in young adult offspring.<h4>Methods</h4>Dietary GI and GL were assessed by questionnaires and interviews in gestation week 30 and offspring were clinically examined at the age of 20 years. Analyses based on 428 mother-offspring dyads were adjusted for maternal smoking during pregnancy, height, pre-pregnancy body mass index (BMI), education, energy intake, and the offspring's ambient level of physical activity. In addition, possible confounding by gestational diabetes mellitus was taken into account.<h4>Outcome measures</h4>Waist circumference, blood pressure, HOMA insulin resistance (HOMA-IR) and plasma levels of fasting glucose, triglycerides, HDL cholesterol, LDL cholesterol, total cholesterol, insulin, and leptin were measured in the offspring.<h4>Results</h4>Significant associations were found between dietary GI in pregnancy and HOMA-IR (the relative increase in HOMA-IR per 10 units' GI increase was 1.09 [95% CI: 1.01, 1.16], p = 0.02), insulin (1.09 [95% CI: 1.02, 1.16], p = 0.01) and leptin (1.21 [95% CI: 1.06, 1.38], p = 0.01) in the offspring; whereas no associations were detected for GL.<h4>Conclusions</h4>Our data suggests that high dietary GI in pregnancy may affect levels of markers for the metabolic syndrome in young adult offspring in a potentially harmful direction.
format	article
author	Inge Danielsen Charlotta Granström Thorhallur Haldorsson Dorte Rytter Bodil Hammer Bech Tine Brink Henriksen Allan Arthur Vaag Sjurdur Frodi Olsen
author_facet	Inge Danielsen Charlotta Granström Thorhallur Haldorsson Dorte Rytter Bodil Hammer Bech Tine Brink Henriksen Allan Arthur Vaag Sjurdur Frodi Olsen
author_sort	Inge Danielsen
title	Dietary glycemic index during pregnancy is associated with biomarkers of the metabolic syndrome in offspring at age 20 years.
title_short	Dietary glycemic index during pregnancy is associated with biomarkers of the metabolic syndrome in offspring at age 20 years.
title_full	Dietary glycemic index during pregnancy is associated with biomarkers of the metabolic syndrome in offspring at age 20 years.
title_fullStr	Dietary glycemic index during pregnancy is associated with biomarkers of the metabolic syndrome in offspring at age 20 years.
title_full_unstemmed	Dietary glycemic index during pregnancy is associated with biomarkers of the metabolic syndrome in offspring at age 20 years.
title_sort	dietary glycemic index during pregnancy is associated with biomarkers of the metabolic syndrome in offspring at age 20 years.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/56eaa2d1c65043e99623353f9697e7bf
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Dietary glycemic index during pregnancy is associated with biomarkers of the metabolic syndrome in offspring at age 20 years.

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