High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy.

<h4>Purpose</h4>To conduct high-resolution imaging of the retinal nerve fiber layer (RNFL) in normal eyes using adaptive optics scanning laser ophthalmoscopy (AO-SLO).<h4>Methods</h4>AO-SLO images were obtained in 20 normal eyes at multiple locations in the posterior polar ar...

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Autores principales:	Kohei Takayama, Sotaro Ooto, Masanori Hangai, Naoko Arakawa, Susumu Oshima, Naohisa Shibata, Masaaki Hanebuchi, Takashi Inoue, Nagahisa Yoshimura
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56edbafec4e048c08d565f9dc2f46c37
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spelling	oai:doaj.org-article:56edbafec4e048c08d565f9dc2f46c372021-11-18T07:25:26ZHigh-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy.1932-620310.1371/journal.pone.0033158https://doaj.org/article/56edbafec4e048c08d565f9dc2f46c372012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22427978/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Purpose</h4>To conduct high-resolution imaging of the retinal nerve fiber layer (RNFL) in normal eyes using adaptive optics scanning laser ophthalmoscopy (AO-SLO).<h4>Methods</h4>AO-SLO images were obtained in 20 normal eyes at multiple locations in the posterior polar area and a circular path with a 3-4-mm diameter around the optic disc. For each eye, images focused on the RNFL were recorded and a montage of AO-SLO images was created.<h4>Results</h4>AO-SLO images for all eyes showed many hyperreflective bundles in the RNFL. Hyperreflective bundles above or below the fovea were seen in an arch from the temporal periphery on either side of a horizontal dividing line to the optic disc. The dark lines among the hyperreflective bundles were narrower around the optic disc compared with those in the temporal raphe. The hyperreflective bundles corresponded with the direction of the striations on SLO red-free images. The resolution and contrast of the bundles were much higher in AO-SLO images than in red-free fundus photography or SLO red-free images. The mean hyperreflective bundle width around the optic disc had a double-humped shape; the bundles at the temporal and nasal sides of the optic disc were narrower than those above and below the optic disc (P<0.001). RNFL thickness obtained by optical coherence tomography correlated with the hyperreflective bundle widths on AO-SLO (P<0.001)<h4>Conclusions</h4>AO-SLO revealed hyperreflective bundles and dark lines in the RNFL, believed to be retinal nerve fiber bundles and Müller cell septa. The widths of the nerve fiber bundles appear to be proportional to the RNFL thickness at equivalent distances from the optic disc.Kohei TakayamaSotaro OotoMasanori HangaiNaoko ArakawaSusumu OshimaNaohisa ShibataMasaaki HanebuchiTakashi InoueNagahisa YoshimuraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 3, p e33158 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kohei Takayama Sotaro Ooto Masanori Hangai Naoko Arakawa Susumu Oshima Naohisa Shibata Masaaki Hanebuchi Takashi Inoue Nagahisa Yoshimura High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy.
description	<h4>Purpose</h4>To conduct high-resolution imaging of the retinal nerve fiber layer (RNFL) in normal eyes using adaptive optics scanning laser ophthalmoscopy (AO-SLO).<h4>Methods</h4>AO-SLO images were obtained in 20 normal eyes at multiple locations in the posterior polar area and a circular path with a 3-4-mm diameter around the optic disc. For each eye, images focused on the RNFL were recorded and a montage of AO-SLO images was created.<h4>Results</h4>AO-SLO images for all eyes showed many hyperreflective bundles in the RNFL. Hyperreflective bundles above or below the fovea were seen in an arch from the temporal periphery on either side of a horizontal dividing line to the optic disc. The dark lines among the hyperreflective bundles were narrower around the optic disc compared with those in the temporal raphe. The hyperreflective bundles corresponded with the direction of the striations on SLO red-free images. The resolution and contrast of the bundles were much higher in AO-SLO images than in red-free fundus photography or SLO red-free images. The mean hyperreflective bundle width around the optic disc had a double-humped shape; the bundles at the temporal and nasal sides of the optic disc were narrower than those above and below the optic disc (P<0.001). RNFL thickness obtained by optical coherence tomography correlated with the hyperreflective bundle widths on AO-SLO (P<0.001)<h4>Conclusions</h4>AO-SLO revealed hyperreflective bundles and dark lines in the RNFL, believed to be retinal nerve fiber bundles and Müller cell septa. The widths of the nerve fiber bundles appear to be proportional to the RNFL thickness at equivalent distances from the optic disc.
format	article
author	Kohei Takayama Sotaro Ooto Masanori Hangai Naoko Arakawa Susumu Oshima Naohisa Shibata Masaaki Hanebuchi Takashi Inoue Nagahisa Yoshimura
author_facet	Kohei Takayama Sotaro Ooto Masanori Hangai Naoko Arakawa Susumu Oshima Naohisa Shibata Masaaki Hanebuchi Takashi Inoue Nagahisa Yoshimura
author_sort	Kohei Takayama
title	High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy.
title_short	High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy.
title_full	High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy.
title_fullStr	High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy.
title_full_unstemmed	High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy.
title_sort	high-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/56edbafec4e048c08d565f9dc2f46c37
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High-resolution imaging of the retinal nerve fiber layer in normal eyes using adaptive optics scanning laser ophthalmoscopy.

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