Clampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of GPCR, CXCR4

Aging and Inflammation: Targeting a cellular receptor reduces the deleterious inflammation during aging and anti-cancer therapy A sensing protein that is increased in response to DNA damage can be targeted to reduce inflammation and collateral damage during anti-cancer therapy and aging. Scientists...

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Autores principales:	Raji R. Nair, Shreyas V. Madiwale, Deepak Kumar Saini
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/56efcd0e49494735bd73ee10009830ef
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spelling	oai:doaj.org-article:56efcd0e49494735bd73ee10009830ef2021-12-02T13:41:46ZClampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of GPCR, CXCR410.1038/s41514-018-0028-02056-3973https://doaj.org/article/56efcd0e49494735bd73ee10009830ef2018-08-01T00:00:00Zhttps://doi.org/10.1038/s41514-018-0028-0https://doaj.org/toc/2056-3973Aging and Inflammation: Targeting a cellular receptor reduces the deleterious inflammation during aging and anti-cancer therapy A sensing protein that is increased in response to DNA damage can be targeted to reduce inflammation and collateral damage during anti-cancer therapy and aging. Scientists at Saini Lab at the Indian Institute of Science have identified the protein that drives sustained and detrimental inflammation when the DNA of cells are damaged, such as during normal human aging or during anti-cancer therapy. Furthermore, blocking the functions of this protein and associated pathway was able to reduce the inflammation to less harmful levels. This discovery could potentially enable safer and more effective anti-cancer therapy by protecting non-cancerous cells surrounding tumors from lethal inflammation. Further studies on this protein could also reduce age associated inflammation, allowing us to age gracefully and healthily.Raji R. NairShreyas V. MadiwaleDeepak Kumar SainiNature PortfolioarticleGeriatricsRC952-954.6ENnpj Aging and Mechanisms of Disease, Vol 4, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Geriatrics RC952-954.6
spellingShingle	Geriatrics RC952-954.6 Raji R. Nair Shreyas V. Madiwale Deepak Kumar Saini Clampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of GPCR, CXCR4
description	Aging and Inflammation: Targeting a cellular receptor reduces the deleterious inflammation during aging and anti-cancer therapy A sensing protein that is increased in response to DNA damage can be targeted to reduce inflammation and collateral damage during anti-cancer therapy and aging. Scientists at Saini Lab at the Indian Institute of Science have identified the protein that drives sustained and detrimental inflammation when the DNA of cells are damaged, such as during normal human aging or during anti-cancer therapy. Furthermore, blocking the functions of this protein and associated pathway was able to reduce the inflammation to less harmful levels. This discovery could potentially enable safer and more effective anti-cancer therapy by protecting non-cancerous cells surrounding tumors from lethal inflammation. Further studies on this protein could also reduce age associated inflammation, allowing us to age gracefully and healthily.
format	article
author	Raji R. Nair Shreyas V. Madiwale Deepak Kumar Saini
author_facet	Raji R. Nair Shreyas V. Madiwale Deepak Kumar Saini
author_sort	Raji R. Nair
title	Clampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of GPCR, CXCR4
title_short	Clampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of GPCR, CXCR4
title_full	Clampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of GPCR, CXCR4
title_fullStr	Clampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of GPCR, CXCR4
title_full_unstemmed	Clampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of GPCR, CXCR4
title_sort	clampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of gpcr, cxcr4
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/56efcd0e49494735bd73ee10009830ef
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Clampdown of inflammation in aging and anticancer therapies by limiting upregulation and activation of GPCR, CXCR4

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