Impact of the superoxide dismutase 2 Val16Ala polymorphism on the relationship between valproic acid exposure and elevation of γ-glutamyltransferase in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis.

Impact of the superoxide dismutase 2 Val16Ala polymorphism on the relationship between valproic acid exposure and elevation of γ-glutamyltransferase in patients with epilepsy: a population pharmacokinetic-pharmacodynamic analysis.

<h4>Background</h4>There has been accumulating evidence that there are associations among γ-glutamyltransferase (γ-GT) elevation and all-cause mortality, cardiovascular diseases and metabolic diseases, including nonalcoholic fatty liver disease. The primary objective of this study was to...

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Autores principales: Naoki Ogusu, Junji Saruwatari, Hiroo Nakashima, Madoka Noai, Miki Nishimura, Mariko Deguchi, Kentaro Oniki, Norio Yasui-Furukori, Sunao Kaneko, Takateru Ishitsu, Kazuko Nakagaswa
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/56f37d4bfa8b4f728fc3181cce8130ad
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