Small molecule allosteric inhibitors of RORγt block Th17-dependent inflammation and associated gene expression in vivo.
Retinoic acid receptor-related orphan nuclear receptor (ROR) γt is a member of the RORC nuclear hormone receptor family of transcription factors. RORγt functions as a critical regulator of thymopoiesis and immune responses. RORγt is expressed in multiple immune cell populations including Th17 cells,...
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
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Format: | article |
Language: | EN |
Published: |
Public Library of Science (PLoS)
2021
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Subjects: | |
Online Access: | https://doaj.org/article/56f95d2f88a74dbfab93005fd298c8a6 |
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