AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells

Resistance to the new generation EGFR-TKI, Osimertinib, can emerge in patients with EGFR-mutated lung cancer. Here, the authors show that AXL, which is activated by osimertinib, can promote the emergence of tolerant lung cancer cell thus conferring resistance to osimertinib and propose the combinati...

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Autores principales:	Hirokazu Taniguchi, Tadaaki Yamada, Rong Wang, Keiko Tanimura, Yuta Adachi, Akihiro Nishiyama, Azusa Tanimoto, Shinji Takeuchi, Luiz H. Araujo, Mariana Boroni, Akihiro Yoshimura, Shinsuke Shiotsu, Isao Matsumoto, Satoshi Watanabe, Toshiaki Kikuchi, Satoru Miura, Hiroshi Tanaka, Takeshi Kitazaki, Hiroyuki Yamaguchi, Hiroshi Mukae, Junji Uchino, Hisanori Uehara, Koichi Takayama, Seiji Yano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/56fa97cab04d4e0d8784ee4ba0940412
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spelling	oai:doaj.org-article:56fa97cab04d4e0d8784ee4ba09404122021-12-02T14:40:20ZAXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells10.1038/s41467-018-08074-02041-1723https://doaj.org/article/56fa97cab04d4e0d8784ee4ba09404122019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08074-0https://doaj.org/toc/2041-1723Resistance to the new generation EGFR-TKI, Osimertinib, can emerge in patients with EGFR-mutated lung cancer. Here, the authors show that AXL, which is activated by osimertinib, can promote the emergence of tolerant lung cancer cell thus conferring resistance to osimertinib and propose the combination of Osimertinib with AXL inhibitor as a potential therapeutic approach in such resistant cancers.Hirokazu TaniguchiTadaaki YamadaRong WangKeiko TanimuraYuta AdachiAkihiro NishiyamaAzusa TanimotoShinji TakeuchiLuiz H. AraujoMariana BoroniAkihiro YoshimuraShinsuke ShiotsuIsao MatsumotoSatoshi WatanabeToshiaki KikuchiSatoru MiuraHiroshi TanakaTakeshi KitazakiHiroyuki YamaguchiHiroshi MukaeJunji UchinoHisanori UeharaKoichi TakayamaSeiji YanoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hirokazu Taniguchi Tadaaki Yamada Rong Wang Keiko Tanimura Yuta Adachi Akihiro Nishiyama Azusa Tanimoto Shinji Takeuchi Luiz H. Araujo Mariana Boroni Akihiro Yoshimura Shinsuke Shiotsu Isao Matsumoto Satoshi Watanabe Toshiaki Kikuchi Satoru Miura Hiroshi Tanaka Takeshi Kitazaki Hiroyuki Yamaguchi Hiroshi Mukae Junji Uchino Hisanori Uehara Koichi Takayama Seiji Yano AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
description	Resistance to the new generation EGFR-TKI, Osimertinib, can emerge in patients with EGFR-mutated lung cancer. Here, the authors show that AXL, which is activated by osimertinib, can promote the emergence of tolerant lung cancer cell thus conferring resistance to osimertinib and propose the combination of Osimertinib with AXL inhibitor as a potential therapeutic approach in such resistant cancers.
format	article
author	Hirokazu Taniguchi Tadaaki Yamada Rong Wang Keiko Tanimura Yuta Adachi Akihiro Nishiyama Azusa Tanimoto Shinji Takeuchi Luiz H. Araujo Mariana Boroni Akihiro Yoshimura Shinsuke Shiotsu Isao Matsumoto Satoshi Watanabe Toshiaki Kikuchi Satoru Miura Hiroshi Tanaka Takeshi Kitazaki Hiroyuki Yamaguchi Hiroshi Mukae Junji Uchino Hisanori Uehara Koichi Takayama Seiji Yano
author_facet	Hirokazu Taniguchi Tadaaki Yamada Rong Wang Keiko Tanimura Yuta Adachi Akihiro Nishiyama Azusa Tanimoto Shinji Takeuchi Luiz H. Araujo Mariana Boroni Akihiro Yoshimura Shinsuke Shiotsu Isao Matsumoto Satoshi Watanabe Toshiaki Kikuchi Satoru Miura Hiroshi Tanaka Takeshi Kitazaki Hiroyuki Yamaguchi Hiroshi Mukae Junji Uchino Hisanori Uehara Koichi Takayama Seiji Yano
author_sort	Hirokazu Taniguchi
title	AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
title_short	AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
title_full	AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
title_fullStr	AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
title_full_unstemmed	AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
title_sort	axl confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/56fa97cab04d4e0d8784ee4ba0940412
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AXL confers intrinsic resistance to osimertinib and advances the emergence of tolerant cells

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