Epidemiological characteristics of novel influenza A (H1N1) in antiviral drug users in Korea.

Soon after the first novel influenza A (H1N1) death was documented in Korea on August 15, 2009, prompt treatment with antiviral drugs was recommended when an infection was suspected. Free antiviral drugs were distributed to patients who met the case definition in the treatment guidelines, and patien...

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Autores principales:	Kyunghi Choi, Sung-il Cho, Masahiro Hashizume, Ho Kim
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/56fad73e9707449daaa40d51e88e1020
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spelling	oai:doaj.org-article:56fad73e9707449daaa40d51e88e10202021-11-18T08:11:39ZEpidemiological characteristics of novel influenza A (H1N1) in antiviral drug users in Korea.1932-620310.1371/journal.pone.0047634https://doaj.org/article/56fad73e9707449daaa40d51e88e10202012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23082184/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Soon after the first novel influenza A (H1N1) death was documented in Korea on August 15, 2009, prompt treatment with antiviral drugs was recommended when an infection was suspected. Free antiviral drugs were distributed to patients who met the case definition in the treatment guidelines, and patients prescribed the antiviral drugs were included in the Antiviral Drug Surveillance System (ADSS). A total of 2,825,821 patients were reported to the ADSS from September 1 to December 31, 2009. Odds ratios were calculated to compare the risks of severe diseases, as indicated by general hospital admissions or intensive care unit (ICU) admissions according to demographic characteristics, underlying medical conditions, and behavioral factors. Approximately 6% of the total population received antiviral drugs during the study period. Of these, 2,709,611 (95.9%) were outpatients, 114,840 (4.06%) were hospitalized, and 1,370 (0.05%) were admitted to the ICU. Children aged 0-9 yr accounted for 33.94% of all reported cases, whereas only 3.89% of the patients were ≥ 60 yr. The estimated incidence of novel influenza A (H1N1) during the pandemic was 5.68/100 of all reported cases. Mortality due to influenza A (H1N1) during the pandemic was 0.33/100,000, with the highest mortality of 1.31/100,000 for patients aged ≥ 60 years. Severe pandemic H1N1 influenza was associated with the presence of one or more underlying medical conditions in elderly aged ≥ 60 years and with lower economic status. Moreover, influenza A (H1N1) appeared to be age-specific in terms of mortality. Although the incidence and admission rates of influenza A (H1N1) were higher in younger age groups, fatal cases were much more likely to occur in the elderly (≥ 60 years). In contrast to earlier influenza A (H1N1) reports, the risks of a severe outcome were elevated among those who were underweight (body mass index < 18.5 kg/m(2)).Kyunghi ChoiSung-il ChoMasahiro HashizumeHo KimPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 10, p e47634 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kyunghi Choi Sung-il Cho Masahiro Hashizume Ho Kim Epidemiological characteristics of novel influenza A (H1N1) in antiviral drug users in Korea.
description	Soon after the first novel influenza A (H1N1) death was documented in Korea on August 15, 2009, prompt treatment with antiviral drugs was recommended when an infection was suspected. Free antiviral drugs were distributed to patients who met the case definition in the treatment guidelines, and patients prescribed the antiviral drugs were included in the Antiviral Drug Surveillance System (ADSS). A total of 2,825,821 patients were reported to the ADSS from September 1 to December 31, 2009. Odds ratios were calculated to compare the risks of severe diseases, as indicated by general hospital admissions or intensive care unit (ICU) admissions according to demographic characteristics, underlying medical conditions, and behavioral factors. Approximately 6% of the total population received antiviral drugs during the study period. Of these, 2,709,611 (95.9%) were outpatients, 114,840 (4.06%) were hospitalized, and 1,370 (0.05%) were admitted to the ICU. Children aged 0-9 yr accounted for 33.94% of all reported cases, whereas only 3.89% of the patients were ≥ 60 yr. The estimated incidence of novel influenza A (H1N1) during the pandemic was 5.68/100 of all reported cases. Mortality due to influenza A (H1N1) during the pandemic was 0.33/100,000, with the highest mortality of 1.31/100,000 for patients aged ≥ 60 years. Severe pandemic H1N1 influenza was associated with the presence of one or more underlying medical conditions in elderly aged ≥ 60 years and with lower economic status. Moreover, influenza A (H1N1) appeared to be age-specific in terms of mortality. Although the incidence and admission rates of influenza A (H1N1) were higher in younger age groups, fatal cases were much more likely to occur in the elderly (≥ 60 years). In contrast to earlier influenza A (H1N1) reports, the risks of a severe outcome were elevated among those who were underweight (body mass index < 18.5 kg/m(2)).
format	article
author	Kyunghi Choi Sung-il Cho Masahiro Hashizume Ho Kim
author_facet	Kyunghi Choi Sung-il Cho Masahiro Hashizume Ho Kim
author_sort	Kyunghi Choi
title	Epidemiological characteristics of novel influenza A (H1N1) in antiviral drug users in Korea.
title_short	Epidemiological characteristics of novel influenza A (H1N1) in antiviral drug users in Korea.
title_full	Epidemiological characteristics of novel influenza A (H1N1) in antiviral drug users in Korea.
title_fullStr	Epidemiological characteristics of novel influenza A (H1N1) in antiviral drug users in Korea.
title_full_unstemmed	Epidemiological characteristics of novel influenza A (H1N1) in antiviral drug users in Korea.
title_sort	epidemiological characteristics of novel influenza a (h1n1) in antiviral drug users in korea.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/56fad73e9707449daaa40d51e88e1020
work_keys_str_mv	AT kyunghichoi epidemiologicalcharacteristicsofnovelinfluenzaah1n1inantiviraldrugusersinkorea AT sungilcho epidemiologicalcharacteristicsofnovelinfluenzaah1n1inantiviraldrugusersinkorea AT masahirohashizume epidemiologicalcharacteristicsofnovelinfluenzaah1n1inantiviraldrugusersinkorea AT hokim epidemiologicalcharacteristicsofnovelinfluenzaah1n1inantiviraldrugusersinkorea
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Epidemiological characteristics of novel influenza A (H1N1) in antiviral drug users in Korea.

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