A Comparative Study of the Hepatoprotective Effect of <i>Centella asiatica</i> Extract (CA-HE50) on Lipopolysaccharide/<span style="font-variant: small-caps">d</span>-galactosamine-Induced Acute Liver Injury in C57BL/6 Mice

A Comparative Study of the Hepatoprotective Effect of <i>Centella asiatica</i> Extract (CA-HE50) on Lipopolysaccharide/<span style="font-variant: small-caps">d</span>-galactosamine-Induced Acute Liver Injury in C57BL/6 Mice

Acute liver failure (ALF) refers to the sudden loss of liver function and is accompanied by several complications. In a previous study, we revealed the protective effect of <i>Centella asiatica</i> 50% ethanol extract (CA-HE50) on acetaminophen-induced liver injury. In the present study,...

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Autores principales: Woojae Hong, Jeon Hwang-Bo, Hyelin Jeon, Minsung Ko, Joongyeon Choi, Yong-Joon Jeong, Jae-Hyun Park, Inhye Kim, Tae-Woo Kim, Hyunggun Kim, Se-Chan Kang
Formato: article
Lenguaje:EN
Publicado: MDPI AG 2021
Materias:
<i>Centella asiatica</i>
acute liver failure
hepatoprotective effect
antioxidant
Nutrition. Foods and food supply
TX341-641
Acceso en línea:https://doaj.org/article/56fb4edfc1da41b5bbc2fe5a8042de24
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spelling oai:doaj.org-article:56fb4edfc1da41b5bbc2fe5a8042de242021-11-25T18:36:41ZA Comparative Study of the Hepatoprotective Effect of <i>Centella asiatica</i> Extract (CA-HE50) on Lipopolysaccharide/<span style="font-variant: small-caps">d</span>-galactosamine-Induced Acute Liver Injury in C57BL/6 Mice10.3390/nu131140902072-6643https://doaj.org/article/56fb4edfc1da41b5bbc2fe5a8042de242021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4090https://doaj.org/toc/2072-6643Acute liver failure (ALF) refers to the sudden loss of liver function and is accompanied by several complications. In a previous study, we revealed the protective effect of <i>Centella asiatica</i> 50% ethanol extract (CA-HE50) on acetaminophen-induced liver injury. In the present study, we investigate the hepatoprotective effect of CA-HE50 in a lipopolysaccharide/galactosamine (LPS-D-Gal)-induced ALF animal model and compare it to existing therapeutic silymarin, <i>Lentinus edodes</i> mycelia (LEM) extracts, ursodeoxycholic acid (UDCA) and dimethyl diphenyl bicarboxylate (DDB). Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were decreased in the CA-HE50, silymarin, LEM, UDCA and DDB groups compared to the vehicle control group. In particular, AST and ALT levels of the 200 mg/kg CA-HE50 group were significantly decreased compared to positive control groups. Lactate dehydrogenase (LDH) levels were significantly decreased in the CA-HE50, silymarin, LEM, UDCA and DDB groups compared to the vehicle control group and LDH levels of the 200 mg/kg CA-HE50 group were similar to those of the positive control groups. Superoxide dismutase (SOD) activity was significantly increased in the 100 mg/kg CA-HE50, LEM and UDCA groups compared to the vehicle control group and, in particular, the 100 mg/kg CA-HE50 group increased significantly compared to positive control groups. In addition, the histopathological lesion score was significantly decreased in the CA-HE50 and positive control groups compared with the vehicle control group and the histopathological lesion score of the 200 mg/kg CA-HE50 group was similar to that of the positive control groups. These results show that CA-HE50 has antioxidant and hepatoprotective effects at a level similar to that of silymarin, LEM, UDCA and DDB, which are known to have hepatoprotective effects; further, CA-HE50 has potential as a prophylactic and therapeutic agent in ALF.Woojae HongJeon Hwang-BoHyelin JeonMinsung KoJoongyeon ChoiYong-Joon JeongJae-Hyun ParkInhye KimTae-Woo KimHyunggun KimSe-Chan KangMDPI AGarticle<i>Centella asiatica</i>acute liver failurehepatoprotective effectantioxidantNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4090, p 4090 (2021)
institution DOAJ
collection DOAJ
language EN
topic <i>Centella asiatica</i>
acute liver failure
hepatoprotective effect
antioxidant
Nutrition. Foods and food supply
TX341-641
spellingShingle <i>Centella asiatica</i>
acute liver failure
hepatoprotective effect
antioxidant
Nutrition. Foods and food supply
TX341-641
Woojae Hong
Jeon Hwang-Bo
Hyelin Jeon
Minsung Ko
Joongyeon Choi
Yong-Joon Jeong
Jae-Hyun Park
Inhye Kim
Tae-Woo Kim
Hyunggun Kim
Se-Chan Kang
A Comparative Study of the Hepatoprotective Effect of <i>Centella asiatica</i> Extract (CA-HE50) on Lipopolysaccharide/<span style="font-variant: small-caps">d</span>-galactosamine-Induced Acute Liver Injury in C57BL/6 Mice
description Acute liver failure (ALF) refers to the sudden loss of liver function and is accompanied by several complications. In a previous study, we revealed the protective effect of <i>Centella asiatica</i> 50% ethanol extract (CA-HE50) on acetaminophen-induced liver injury. In the present study, we investigate the hepatoprotective effect of CA-HE50 in a lipopolysaccharide/galactosamine (LPS-D-Gal)-induced ALF animal model and compare it to existing therapeutic silymarin, <i>Lentinus edodes</i> mycelia (LEM) extracts, ursodeoxycholic acid (UDCA) and dimethyl diphenyl bicarboxylate (DDB). Serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels were decreased in the CA-HE50, silymarin, LEM, UDCA and DDB groups compared to the vehicle control group. In particular, AST and ALT levels of the 200 mg/kg CA-HE50 group were significantly decreased compared to positive control groups. Lactate dehydrogenase (LDH) levels were significantly decreased in the CA-HE50, silymarin, LEM, UDCA and DDB groups compared to the vehicle control group and LDH levels of the 200 mg/kg CA-HE50 group were similar to those of the positive control groups. Superoxide dismutase (SOD) activity was significantly increased in the 100 mg/kg CA-HE50, LEM and UDCA groups compared to the vehicle control group and, in particular, the 100 mg/kg CA-HE50 group increased significantly compared to positive control groups. In addition, the histopathological lesion score was significantly decreased in the CA-HE50 and positive control groups compared with the vehicle control group and the histopathological lesion score of the 200 mg/kg CA-HE50 group was similar to that of the positive control groups. These results show that CA-HE50 has antioxidant and hepatoprotective effects at a level similar to that of silymarin, LEM, UDCA and DDB, which are known to have hepatoprotective effects; further, CA-HE50 has potential as a prophylactic and therapeutic agent in ALF.
format article
author Woojae Hong
Jeon Hwang-Bo
Hyelin Jeon
Minsung Ko
Joongyeon Choi
Yong-Joon Jeong
Jae-Hyun Park
Inhye Kim
Tae-Woo Kim
Hyunggun Kim
Se-Chan Kang
author_facet Woojae Hong
Jeon Hwang-Bo
Hyelin Jeon
Minsung Ko
Joongyeon Choi
Yong-Joon Jeong
Jae-Hyun Park
Inhye Kim
Tae-Woo Kim
Hyunggun Kim
Se-Chan Kang
author_sort Woojae Hong
title A Comparative Study of the Hepatoprotective Effect of <i>Centella asiatica</i> Extract (CA-HE50) on Lipopolysaccharide/<span style="font-variant: small-caps">d</span>-galactosamine-Induced Acute Liver Injury in C57BL/6 Mice
title_short A Comparative Study of the Hepatoprotective Effect of <i>Centella asiatica</i> Extract (CA-HE50) on Lipopolysaccharide/<span style="font-variant: small-caps">d</span>-galactosamine-Induced Acute Liver Injury in C57BL/6 Mice
title_full A Comparative Study of the Hepatoprotective Effect of <i>Centella asiatica</i> Extract (CA-HE50) on Lipopolysaccharide/<span style="font-variant: small-caps">d</span>-galactosamine-Induced Acute Liver Injury in C57BL/6 Mice
title_fullStr A Comparative Study of the Hepatoprotective Effect of <i>Centella asiatica</i> Extract (CA-HE50) on Lipopolysaccharide/<span style="font-variant: small-caps">d</span>-galactosamine-Induced Acute Liver Injury in C57BL/6 Mice
title_full_unstemmed A Comparative Study of the Hepatoprotective Effect of <i>Centella asiatica</i> Extract (CA-HE50) on Lipopolysaccharide/<span style="font-variant: small-caps">d</span>-galactosamine-Induced Acute Liver Injury in C57BL/6 Mice
title_sort comparative study of the hepatoprotective effect of <i>centella asiatica</i> extract (ca-he50) on lipopolysaccharide/<span style="font-variant: small-caps">d</span>-galactosamine-induced acute liver injury in c57bl/6 mice
publisher MDPI AG
publishDate 2021
url https://doaj.org/article/56fb4edfc1da41b5bbc2fe5a8042de24
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