Association study of six candidate genes with major depressive disorder in the North-Western population of Pakistan.
People around the world are currently affected by Major Depressive Disorder (MDD). Despite its many aspects, symptoms, manifestations and impacts, efforts have been made to identify the root causes of the disorder. In particular, genetic studies have concentrated on identifying candidate genes for M...
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oai:doaj.org-article:56fe10ae496a4982b5ec36319833db3d2021-12-02T20:14:58ZAssociation study of six candidate genes with major depressive disorder in the North-Western population of Pakistan.1932-620310.1371/journal.pone.0248454https://doaj.org/article/56fe10ae496a4982b5ec36319833db3d2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0248454https://doaj.org/toc/1932-6203People around the world are currently affected by Major Depressive Disorder (MDD). Despite its many aspects, symptoms, manifestations and impacts, efforts have been made to identify the root causes of the disorder. In particular, genetic studies have concentrated on identifying candidate genes for MDD and exploring associations between these genes and some specific group of individuals. The aim of this research was to find out the association between single nucleotide polymorphisms in 6 candidate genes linked to the neurobiology of major depressive disorder in the North-Western population of Pakistan. We performed a case-control analysis, with 400 MDD and 232 controls. A trained psychiatrist or clinical psychologists evaluated the patients. Six polymorphisms were genotyped and tested for allele and genotype association with MDD. There were no statistical variations between MDD patients and healthy controls for genotypic and allelic distribution of all the polymorphisms observed. Thus, our analysis does not support the major role of these polymorphisms in contributing to MDD susceptibility, although it does not preclude minor impact. The statistically significant correlation between six polymorphisms and major depressive disorder in the studied population was not observed. There are inconsistencies in investigations around the world. Future research, including GWAS and association analysis on larger scale should be addressed for further validation and replication of the present findings.Naqash AlamSadiq AliNazia AkbarMuhammad IlyasHabib AhmedArooj MustafaShehzada KhurramZeeshan SajidNajeeb UllahShumaila QayyumTariq RahimMian Syed UsmanNawad AliImad KhanKhola PervezBiBi SumairaNasir AliNighat SultanaAdeel Yunus TanoliMadiha IslamPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0248454 (2021) |
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Medicine R Science Q |
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Medicine R Science Q Naqash Alam Sadiq Ali Nazia Akbar Muhammad Ilyas Habib Ahmed Arooj Mustafa Shehzada Khurram Zeeshan Sajid Najeeb Ullah Shumaila Qayyum Tariq Rahim Mian Syed Usman Nawad Ali Imad Khan Khola Pervez BiBi Sumaira Nasir Ali Nighat Sultana Adeel Yunus Tanoli Madiha Islam Association study of six candidate genes with major depressive disorder in the North-Western population of Pakistan. |
| description |
People around the world are currently affected by Major Depressive Disorder (MDD). Despite its many aspects, symptoms, manifestations and impacts, efforts have been made to identify the root causes of the disorder. In particular, genetic studies have concentrated on identifying candidate genes for MDD and exploring associations between these genes and some specific group of individuals. The aim of this research was to find out the association between single nucleotide polymorphisms in 6 candidate genes linked to the neurobiology of major depressive disorder in the North-Western population of Pakistan. We performed a case-control analysis, with 400 MDD and 232 controls. A trained psychiatrist or clinical psychologists evaluated the patients. Six polymorphisms were genotyped and tested for allele and genotype association with MDD. There were no statistical variations between MDD patients and healthy controls for genotypic and allelic distribution of all the polymorphisms observed. Thus, our analysis does not support the major role of these polymorphisms in contributing to MDD susceptibility, although it does not preclude minor impact. The statistically significant correlation between six polymorphisms and major depressive disorder in the studied population was not observed. There are inconsistencies in investigations around the world. Future research, including GWAS and association analysis on larger scale should be addressed for further validation and replication of the present findings. |
| format |
article |
| author |
Naqash Alam Sadiq Ali Nazia Akbar Muhammad Ilyas Habib Ahmed Arooj Mustafa Shehzada Khurram Zeeshan Sajid Najeeb Ullah Shumaila Qayyum Tariq Rahim Mian Syed Usman Nawad Ali Imad Khan Khola Pervez BiBi Sumaira Nasir Ali Nighat Sultana Adeel Yunus Tanoli Madiha Islam |
| author_facet |
Naqash Alam Sadiq Ali Nazia Akbar Muhammad Ilyas Habib Ahmed Arooj Mustafa Shehzada Khurram Zeeshan Sajid Najeeb Ullah Shumaila Qayyum Tariq Rahim Mian Syed Usman Nawad Ali Imad Khan Khola Pervez BiBi Sumaira Nasir Ali Nighat Sultana Adeel Yunus Tanoli Madiha Islam |
| author_sort |
Naqash Alam |
| title |
Association study of six candidate genes with major depressive disorder in the North-Western population of Pakistan. |
| title_short |
Association study of six candidate genes with major depressive disorder in the North-Western population of Pakistan. |
| title_full |
Association study of six candidate genes with major depressive disorder in the North-Western population of Pakistan. |
| title_fullStr |
Association study of six candidate genes with major depressive disorder in the North-Western population of Pakistan. |
| title_full_unstemmed |
Association study of six candidate genes with major depressive disorder in the North-Western population of Pakistan. |
| title_sort |
association study of six candidate genes with major depressive disorder in the north-western population of pakistan. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2021 |
| url |
https://doaj.org/article/56fe10ae496a4982b5ec36319833db3d |
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