Evolution of the clonogenic potential of human epidermal stem/progenitor cells with age

Olivia Zobiri, Nathalie Deshayes, Michelle Rathman-JosserandDepartment of Biological Research, L&#39;Or&eacute;al Advanced Research, Clichy Cedex, FranceAbstract: A number of clinical observations have indicated that the regenerative potential and overall function of the epidermis is...

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Autores principales:	Zobiri O, Deshayes N, Rathman-Josser, M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/56ffb255c0064f0b98a5fa0476036786
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spelling	oai:doaj.org-article:56ffb255c0064f0b98a5fa04760367862021-12-02T05:46:01ZEvolution of the clonogenic potential of human epidermal stem/progenitor cells with age1178-6957https://doaj.org/article/56ffb255c0064f0b98a5fa04760367862012-02-01T00:00:00Zhttp://www.dovepress.com/evolution-of-the-clonogenic-potential-of-human-epidermal-stemprogenito-a9384https://doaj.org/toc/1178-6957Olivia Zobiri, Nathalie Deshayes, Michelle Rathman-JosserandDepartment of Biological Research, L&#39;Or&eacute;al Advanced Research, Clichy Cedex, FranceAbstract: A number of clinical observations have indicated that the regenerative potential and overall function of the epidermis is modified with age. The epidermis becomes thinner, repairs itself less efficiently after wounding, and presents modified barrier function recovery. In addition, the dermal papillae flatten out with increasing age, suggesting a modification in the interaction between epidermal and dermal compartments. As the epidermal regenerative capacity is dependent upon stem and progenitor cell function, it is naturally of interest to identify and understand age-related changes in these particular keratinocyte populations. Previous studies have indicated that the number of stem cells does not decrease with age in mouse models but little solid evidence is currently available concerning human skin. The objective of this study was to evaluate the clonogenic potential of keratinocyte populations isolated from the epidermis of over 50 human donors ranging from 18 to 71 years old. The data indicate that the number of epidermal cells presenting high regenerative potential does not dramatically decline with age in human skin. The authors believe that changes in the microenvironment controlling epidermal basal cell activity are more likely to explain the differences in epidermal function observed with increasing age.Keywords: skin, epidermal stem cells, aging, colony-forming efficiency testZobiri ODeshayes NRathman-JosserMDove Medical PressarticleCytologyQH573-671ENStem Cells and Cloning: Advances and Applications, Vol 2012, Iss default, Pp 1-4 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Zobiri O Deshayes N Rathman-Josser M Evolution of the clonogenic potential of human epidermal stem/progenitor cells with age
description	Olivia Zobiri, Nathalie Deshayes, Michelle Rathman-JosserandDepartment of Biological Research, L&#39;Or&eacute;al Advanced Research, Clichy Cedex, FranceAbstract: A number of clinical observations have indicated that the regenerative potential and overall function of the epidermis is modified with age. The epidermis becomes thinner, repairs itself less efficiently after wounding, and presents modified barrier function recovery. In addition, the dermal papillae flatten out with increasing age, suggesting a modification in the interaction between epidermal and dermal compartments. As the epidermal regenerative capacity is dependent upon stem and progenitor cell function, it is naturally of interest to identify and understand age-related changes in these particular keratinocyte populations. Previous studies have indicated that the number of stem cells does not decrease with age in mouse models but little solid evidence is currently available concerning human skin. The objective of this study was to evaluate the clonogenic potential of keratinocyte populations isolated from the epidermis of over 50 human donors ranging from 18 to 71 years old. The data indicate that the number of epidermal cells presenting high regenerative potential does not dramatically decline with age in human skin. The authors believe that changes in the microenvironment controlling epidermal basal cell activity are more likely to explain the differences in epidermal function observed with increasing age.Keywords: skin, epidermal stem cells, aging, colony-forming efficiency test
format	article
author	Zobiri O Deshayes N Rathman-Josser M
author_facet	Zobiri O Deshayes N Rathman-Josser M
author_sort	Zobiri O
title	Evolution of the clonogenic potential of human epidermal stem/progenitor cells with age
title_short	Evolution of the clonogenic potential of human epidermal stem/progenitor cells with age
title_full	Evolution of the clonogenic potential of human epidermal stem/progenitor cells with age
title_fullStr	Evolution of the clonogenic potential of human epidermal stem/progenitor cells with age
title_full_unstemmed	Evolution of the clonogenic potential of human epidermal stem/progenitor cells with age
title_sort	evolution of the clonogenic potential of human epidermal stem/progenitor cells with age
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/56ffb255c0064f0b98a5fa0476036786
work_keys_str_mv	AT zobirio evolutionoftheclonogenicpotentialofhumanepidermalstemprogenitorcellswithage AT deshayesn evolutionoftheclonogenicpotentialofhumanepidermalstemprogenitorcellswithage AT rathmanjosser evolutionoftheclonogenicpotentialofhumanepidermalstemprogenitorcellswithage AT m evolutionoftheclonogenicpotentialofhumanepidermalstemprogenitorcellswithage
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Evolution of the clonogenic potential of human epidermal stem/progenitor cells with age

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