Islet Autoantibodies in the Patients with Sjogren’s Syndrome and Thyroid Disease and Risk of Progression to Latent Autoimmune Diabetes in Adults: A Case Series

Islet Autoantibodies in the Patients with Sjogren’s Syndrome and Thyroid Disease and Risk of Progression to Latent Autoimmune Diabetes in Adults: A Case Series

Song Wen, Wenjing Jiang, Ligang Zhou Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of ChinaCorrespondence: Ligang ZhouDepartment of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s...

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Autores principales: Wen S, Jiang W, Zhou L
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2021
Materias:
latent onset autoimmune diabetes in adults (lada)
hashimoto's thyroiditis (ht)
sjogren's syndrome (ss)
autoimmune diseases
glutamic acid decarboxylase 65 antibody (gad65-ab)
and insulin autoantibody (iaa-ab).
Specialties of internal medicine
RC581-951
Acceso en línea:https://doaj.org/article/56ffc442a9ca483cb2e6e2801ef3c7ce
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spelling oai:doaj.org-article:56ffc442a9ca483cb2e6e2801ef3c7ce2021-12-02T17:09:41ZIslet Autoantibodies in the Patients with Sjogren’s Syndrome and Thyroid Disease and Risk of Progression to Latent Autoimmune Diabetes in Adults: A Case Series1178-7007https://doaj.org/article/56ffc442a9ca483cb2e6e2801ef3c7ce2021-03-01T00:00:00Zhttps://www.dovepress.com/islet-autoantibodies-in-the-patients-with-sjogrenrsquos-syndrome-and-t-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Song Wen, Wenjing Jiang, Ligang Zhou Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of ChinaCorrespondence: Ligang ZhouDepartment of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of ChinaTel +8613611927616Email zhouligang@yahoo.comAbstract: The glutamic acid decarboxylase 65 antibody (GAD65-Ab) is an autoimmune marker in some diseases such as diabetes or autoimmune disorders of the central nervous system such as stiff-man syndrome. It can appear with other pancreatic autoantibodies, such as insulin autoantibodies (IAA), presenting as early signs of pancreatic islet β-cells impairing, and play roles in the pathogenesis of type1 diabetes (T1D) and latent autoimmune diabetes in adults (LADA). Positive GAD65-Ab is rarely observed in insulin-dependent diabetic patients with other acquired autoimmune diseases, such as Sjogren’s syndrome (SS). Besides, LADA revealed by islet autoantibodies such as GAD65-Ab can also be complicated with Hashimoto’s thyroiditis (HT), another autoimmune thyroid disease. To date, whether GAD65-Ab positive in patients with autoimmune diseases predicts the onset or progression to T1D or LADA remains unknown. Herein, two unique cases of middle-aged Chinese Han women free from diabetes for three years are described despite their blood tests persistently testing positive for GAD65-Ab or IAA. Both patients suffered from HT and SS. Follow-up OGTTs (oral glucose tolerance test) for three years revealed that the patients had a well-controlled glycemic level and normal pancreatic function. However, one of the patients had a temporary increase of postprandial glucose after a short-term loss of diet control. The presence of auto-immune antibodies in these patients had little impact on glucose tolerance or insulin secretion in 3 years. The study postulate that both the primary immune injury caused by serum GAD65-Ab positive, an autoimmune marker, and increased body weight contribute to the progression of LADA.Keywords: latent onset autoimmune diabetes in adults, LADA, Hashimoto’s thyroiditis, HT, Sjogren’s syndrome, SS, autoimmune diseases, glutamic acid decarboxylase 65 antibody, GAD65-Ab, insulin autoantibody, IAA-AbWen SJiang WZhou LDove Medical Pressarticlelatent onset autoimmune diabetes in adults (lada)hashimoto's thyroiditis (ht)sjogren's syndrome (ss)autoimmune diseasesglutamic acid decarboxylase 65 antibody (gad65-ab)and insulin autoantibody (iaa-ab).Specialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 1025-1033 (2021)
institution DOAJ
collection DOAJ
language EN
topic latent onset autoimmune diabetes in adults (lada)
hashimoto's thyroiditis (ht)
sjogren's syndrome (ss)
autoimmune diseases
glutamic acid decarboxylase 65 antibody (gad65-ab)
and insulin autoantibody (iaa-ab).
Specialties of internal medicine
RC581-951
spellingShingle latent onset autoimmune diabetes in adults (lada)
hashimoto's thyroiditis (ht)
sjogren's syndrome (ss)
autoimmune diseases
glutamic acid decarboxylase 65 antibody (gad65-ab)
and insulin autoantibody (iaa-ab).
Specialties of internal medicine
RC581-951
Wen S
Jiang W
Zhou L
Islet Autoantibodies in the Patients with Sjogren’s Syndrome and Thyroid Disease and Risk of Progression to Latent Autoimmune Diabetes in Adults: A Case Series
description Song Wen, Wenjing Jiang, Ligang Zhou Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of ChinaCorrespondence: Ligang ZhouDepartment of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai, 201399, People’s Republic of ChinaTel +8613611927616Email zhouligang@yahoo.comAbstract: The glutamic acid decarboxylase 65 antibody (GAD65-Ab) is an autoimmune marker in some diseases such as diabetes or autoimmune disorders of the central nervous system such as stiff-man syndrome. It can appear with other pancreatic autoantibodies, such as insulin autoantibodies (IAA), presenting as early signs of pancreatic islet β-cells impairing, and play roles in the pathogenesis of type1 diabetes (T1D) and latent autoimmune diabetes in adults (LADA). Positive GAD65-Ab is rarely observed in insulin-dependent diabetic patients with other acquired autoimmune diseases, such as Sjogren’s syndrome (SS). Besides, LADA revealed by islet autoantibodies such as GAD65-Ab can also be complicated with Hashimoto’s thyroiditis (HT), another autoimmune thyroid disease. To date, whether GAD65-Ab positive in patients with autoimmune diseases predicts the onset or progression to T1D or LADA remains unknown. Herein, two unique cases of middle-aged Chinese Han women free from diabetes for three years are described despite their blood tests persistently testing positive for GAD65-Ab or IAA. Both patients suffered from HT and SS. Follow-up OGTTs (oral glucose tolerance test) for three years revealed that the patients had a well-controlled glycemic level and normal pancreatic function. However, one of the patients had a temporary increase of postprandial glucose after a short-term loss of diet control. The presence of auto-immune antibodies in these patients had little impact on glucose tolerance or insulin secretion in 3 years. The study postulate that both the primary immune injury caused by serum GAD65-Ab positive, an autoimmune marker, and increased body weight contribute to the progression of LADA.Keywords: latent onset autoimmune diabetes in adults, LADA, Hashimoto’s thyroiditis, HT, Sjogren’s syndrome, SS, autoimmune diseases, glutamic acid decarboxylase 65 antibody, GAD65-Ab, insulin autoantibody, IAA-Ab
format article
author Wen S
Jiang W
Zhou L
author_facet Wen S
Jiang W
Zhou L
author_sort Wen S
title Islet Autoantibodies in the Patients with Sjogren’s Syndrome and Thyroid Disease and Risk of Progression to Latent Autoimmune Diabetes in Adults: A Case Series
title_short Islet Autoantibodies in the Patients with Sjogren’s Syndrome and Thyroid Disease and Risk of Progression to Latent Autoimmune Diabetes in Adults: A Case Series
title_full Islet Autoantibodies in the Patients with Sjogren’s Syndrome and Thyroid Disease and Risk of Progression to Latent Autoimmune Diabetes in Adults: A Case Series
title_fullStr Islet Autoantibodies in the Patients with Sjogren’s Syndrome and Thyroid Disease and Risk of Progression to Latent Autoimmune Diabetes in Adults: A Case Series
title_full_unstemmed Islet Autoantibodies in the Patients with Sjogren’s Syndrome and Thyroid Disease and Risk of Progression to Latent Autoimmune Diabetes in Adults: A Case Series
title_sort islet autoantibodies in the patients with sjogren’s syndrome and thyroid disease and risk of progression to latent autoimmune diabetes in adults: a case series
publisher Dove Medical Press
publishDate 2021
url https://doaj.org/article/56ffc442a9ca483cb2e6e2801ef3c7ce
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