Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs

In fission yeast, several lncRNAs act in cis to regulate expression of adjacent genes. Here, the authors show that the conserved Pir2ARS2 protein is targeted, along with splicing factors, to cryptic introns in lncRNAs and recruits effectors, including RNAi machinery, for gene repression.

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Autores principales:	Gobi Thillainadesan, Hua Xiao, Sahana Holla, Jothy Dhakshnamoorthy, Lisa M. Miller Jenkins, David Wheeler, Shiv I. S. Grewal
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5700ae1f518e43c0ae8fc278a9926f5f
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spelling	oai:doaj.org-article:5700ae1f518e43c0ae8fc278a9926f5f2021-12-02T17:15:59ZConserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs10.1038/s41467-020-16280-y2041-1723https://doaj.org/article/5700ae1f518e43c0ae8fc278a9926f5f2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16280-yhttps://doaj.org/toc/2041-1723In fission yeast, several lncRNAs act in cis to regulate expression of adjacent genes. Here, the authors show that the conserved Pir2ARS2 protein is targeted, along with splicing factors, to cryptic introns in lncRNAs and recruits effectors, including RNAi machinery, for gene repression.Gobi ThillainadesanHua XiaoSahana HollaJothy DhakshnamoorthyLisa M. Miller JenkinsDavid WheelerShiv I. S. GrewalNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gobi Thillainadesan Hua Xiao Sahana Holla Jothy Dhakshnamoorthy Lisa M. Miller Jenkins David Wheeler Shiv I. S. Grewal Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs
description	In fission yeast, several lncRNAs act in cis to regulate expression of adjacent genes. Here, the authors show that the conserved Pir2ARS2 protein is targeted, along with splicing factors, to cryptic introns in lncRNAs and recruits effectors, including RNAi machinery, for gene repression.
format	article
author	Gobi Thillainadesan Hua Xiao Sahana Holla Jothy Dhakshnamoorthy Lisa M. Miller Jenkins David Wheeler Shiv I. S. Grewal
author_facet	Gobi Thillainadesan Hua Xiao Sahana Holla Jothy Dhakshnamoorthy Lisa M. Miller Jenkins David Wheeler Shiv I. S. Grewal
author_sort	Gobi Thillainadesan
title	Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs
title_short	Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs
title_full	Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs
title_fullStr	Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs
title_full_unstemmed	Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs
title_sort	conserved protein pir2ars2 mediates gene repression through cryptic introns in lncrnas
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/5700ae1f518e43c0ae8fc278a9926f5f
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Conserved protein Pir2ARS2 mediates gene repression through cryptic introns in lncRNAs

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