Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model

Broadly protective or universal influenza virus vaccines target viral epitopes that appear to be conserved. However, it is unclear whether the virus will be able to escape once immunological pressure is applied to these epitopes through vaccination of large proportions of the population. Studies th...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ericka Kirkpatrick Roubidoux, Juan Manuel Carreño, Meagan McMahon, Kaijun Jiang, Harm van Bakel, Patrick Wilson, Florian Krammer
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/57027ab778c741b39a9c2e0450fe9048
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:57027ab778c741b39a9c2e0450fe9048
record_format	dspace
spelling	oai:doaj.org-article:57027ab778c741b39a9c2e0450fe90482021-11-03T18:15:37ZMutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model2161-21292150-751110.1128/mBio.03617-20https://doaj.org/article/57027ab778c741b39a9c2e0450fe90482021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03617-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 Broadly protective or universal influenza virus vaccines target viral epitopes that appear to be conserved. However, it is unclear whether the virus will be able to escape once immunological pressure is applied to these epitopes through vaccination of large proportions of the population. Studies that investigate the fitness and antigenic characteristics of viruses that escape immunological pressure on these conserved epitopes are therefore urgently needed.Ericka Kirkpatrick RoubidouxJuan Manuel CarreñoMeagan McMahonKaijun JiangHarm van BakelPatrick WilsonFlorian KrammerAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Ericka Kirkpatrick Roubidoux Juan Manuel Carreño Meagan McMahon Kaijun Jiang Harm van Bakel Patrick Wilson Florian Krammer Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model
description	Broadly protective or universal influenza virus vaccines target viral epitopes that appear to be conserved. However, it is unclear whether the virus will be able to escape once immunological pressure is applied to these epitopes through vaccination of large proportions of the population. Studies that investigate the fitness and antigenic characteristics of viruses that escape immunological pressure on these conserved epitopes are therefore urgently needed.
format	article
author	Ericka Kirkpatrick Roubidoux Juan Manuel Carreño Meagan McMahon Kaijun Jiang Harm van Bakel Patrick Wilson Florian Krammer
author_facet	Ericka Kirkpatrick Roubidoux Juan Manuel Carreño Meagan McMahon Kaijun Jiang Harm van Bakel Patrick Wilson Florian Krammer
author_sort	Ericka Kirkpatrick Roubidoux
title	Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model
title_short	Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model
title_full	Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model
title_fullStr	Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model
title_full_unstemmed	Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model
title_sort	mutations in the hemagglutinin stalk domain do not permit escape from a protective, stalk-based vaccine-induced immune response in the mouse model
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/57027ab778c741b39a9c2e0450fe9048
work_keys_str_mv	AT erickakirkpatrickroubidoux mutationsinthehemagglutininstalkdomaindonotpermitescapefromaprotectivestalkbasedvaccineinducedimmuneresponseinthemousemodel AT juanmanuelcarreno mutationsinthehemagglutininstalkdomaindonotpermitescapefromaprotectivestalkbasedvaccineinducedimmuneresponseinthemousemodel AT meaganmcmahon mutationsinthehemagglutininstalkdomaindonotpermitescapefromaprotectivestalkbasedvaccineinducedimmuneresponseinthemousemodel AT kaijunjiang mutationsinthehemagglutininstalkdomaindonotpermitescapefromaprotectivestalkbasedvaccineinducedimmuneresponseinthemousemodel AT harmvanbakel mutationsinthehemagglutininstalkdomaindonotpermitescapefromaprotectivestalkbasedvaccineinducedimmuneresponseinthemousemodel AT patrickwilson mutationsinthehemagglutininstalkdomaindonotpermitescapefromaprotectivestalkbasedvaccineinducedimmuneresponseinthemousemodel AT floriankrammer mutationsinthehemagglutininstalkdomaindonotpermitescapefromaprotectivestalkbasedvaccineinducedimmuneresponseinthemousemodel
_version_	1718445457456234496

Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model

Ejemplares similares