Mutations in the Hemagglutinin Stalk Domain Do Not Permit Escape from a Protective, Stalk-Based Vaccine-Induced Immune Response in the Mouse Model

Broadly protective or universal influenza virus vaccines target viral epitopes that appear to be conserved. However, it is unclear whether the virus will be able to escape once immunological pressure is applied to these epitopes through vaccination of large proportions of the population. Studies th...

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Bibliographic Details
Main Authors: Ericka Kirkpatrick Roubidoux, Juan Manuel Carreño, Meagan McMahon, Kaijun Jiang, Harm van Bakel, Patrick Wilson, Florian Krammer
Format: article
Language:EN
Published: American Society for Microbiology 2021
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Online Access:https://doaj.org/article/57027ab778c741b39a9c2e0450fe9048
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