Adjustment of the Arabidopsis circadian oscillator by sugar signalling dictates the regulation of starch metabolism

Abstract Arabidopsis plants store part of the carbon fixed by photosynthesis as starch to sustain growth at night. Two competing hypotheses have been proposed to explain this diel starch turnover based on either the measurement of starch abundance with respect to circadian time, or the sensing of su...

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Autores principales:	Motohide Seki, Takayuki Ohara, Timothy J. Hearn, Alexander Frank, Viviane C. H. da Silva, Camila Caldana, Alex A. R. Webb, Akiko Satake
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57038c7df6704cfca22d623592e03e18
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spelling	oai:doaj.org-article:57038c7df6704cfca22d623592e03e182021-12-02T12:31:47ZAdjustment of the Arabidopsis circadian oscillator by sugar signalling dictates the regulation of starch metabolism10.1038/s41598-017-08325-y2045-2322https://doaj.org/article/57038c7df6704cfca22d623592e03e182017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-08325-yhttps://doaj.org/toc/2045-2322Abstract Arabidopsis plants store part of the carbon fixed by photosynthesis as starch to sustain growth at night. Two competing hypotheses have been proposed to explain this diel starch turnover based on either the measurement of starch abundance with respect to circadian time, or the sensing of sugars to feedback to the circadian oscillator to dynamically adjust the timing of starch turnover. We report a phase oscillator model that permitted derivation of the ideal responses of the circadian regulation of starch breakdown to maintain sucrose homeostasis. Testing the model predictions using a sugar-unresponsive mutant of Arabidopsis demonstrated that the dynamics of starch turnover arise from the circadian clock measuring and responding to the rate of change of cellular sucrose. Our theory and experiments suggest that starch turnover is controlled by the circadian clock acting as a dynamic homeostat responding to sucrose signals to maintain carbon homeostasis.Motohide SekiTakayuki OharaTimothy J. HearnAlexander FrankViviane C. H. da SilvaCamila CaldanaAlex A. R. WebbAkiko SatakeNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Motohide Seki Takayuki Ohara Timothy J. Hearn Alexander Frank Viviane C. H. da Silva Camila Caldana Alex A. R. Webb Akiko Satake Adjustment of the Arabidopsis circadian oscillator by sugar signalling dictates the regulation of starch metabolism
description	Abstract Arabidopsis plants store part of the carbon fixed by photosynthesis as starch to sustain growth at night. Two competing hypotheses have been proposed to explain this diel starch turnover based on either the measurement of starch abundance with respect to circadian time, or the sensing of sugars to feedback to the circadian oscillator to dynamically adjust the timing of starch turnover. We report a phase oscillator model that permitted derivation of the ideal responses of the circadian regulation of starch breakdown to maintain sucrose homeostasis. Testing the model predictions using a sugar-unresponsive mutant of Arabidopsis demonstrated that the dynamics of starch turnover arise from the circadian clock measuring and responding to the rate of change of cellular sucrose. Our theory and experiments suggest that starch turnover is controlled by the circadian clock acting as a dynamic homeostat responding to sucrose signals to maintain carbon homeostasis.
format	article
author	Motohide Seki Takayuki Ohara Timothy J. Hearn Alexander Frank Viviane C. H. da Silva Camila Caldana Alex A. R. Webb Akiko Satake
author_facet	Motohide Seki Takayuki Ohara Timothy J. Hearn Alexander Frank Viviane C. H. da Silva Camila Caldana Alex A. R. Webb Akiko Satake
author_sort	Motohide Seki
title	Adjustment of the Arabidopsis circadian oscillator by sugar signalling dictates the regulation of starch metabolism
title_short	Adjustment of the Arabidopsis circadian oscillator by sugar signalling dictates the regulation of starch metabolism
title_full	Adjustment of the Arabidopsis circadian oscillator by sugar signalling dictates the regulation of starch metabolism
title_fullStr	Adjustment of the Arabidopsis circadian oscillator by sugar signalling dictates the regulation of starch metabolism
title_full_unstemmed	Adjustment of the Arabidopsis circadian oscillator by sugar signalling dictates the regulation of starch metabolism
title_sort	adjustment of the arabidopsis circadian oscillator by sugar signalling dictates the regulation of starch metabolism
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/57038c7df6704cfca22d623592e03e18
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_version_	1718394279455358976

Adjustment of the Arabidopsis circadian oscillator by sugar signalling dictates the regulation of starch metabolism

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