Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

Serine synthesis from glucose is required even when serine is available from the environment. Here, the authors explain this paradox by showing that the enzyme PHGDH enables nucleotide synthesis by coordinating anabolic fluxes related to central carbon metabolism, independent of its role in serine p...

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Autores principales:	Michael A. Reid, Annamarie E. Allen, Shiyu Liu, Maria V. Liberti, Pei Liu, Xiaojing Liu, Ziwei Dai, Xia Gao, Qian Wang, Ying Liu, Luhua Lai, Jason W. Locasale
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/570cbf552bdf471ba93d9ee853a1c9f2
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spelling	oai:doaj.org-article:570cbf552bdf471ba93d9ee853a1c9f22021-12-02T16:49:33ZSerine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism10.1038/s41467-018-07868-62041-1723https://doaj.org/article/570cbf552bdf471ba93d9ee853a1c9f22018-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07868-6https://doaj.org/toc/2041-1723Serine synthesis from glucose is required even when serine is available from the environment. Here, the authors explain this paradox by showing that the enzyme PHGDH enables nucleotide synthesis by coordinating anabolic fluxes related to central carbon metabolism, independent of its role in serine production.Michael A. ReidAnnamarie E. AllenShiyu LiuMaria V. LibertiPei LiuXiaojing LiuZiwei DaiXia GaoQian WangYing LiuLuhua LaiJason W. LocasaleNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael A. Reid Annamarie E. Allen Shiyu Liu Maria V. Liberti Pei Liu Xiaojing Liu Ziwei Dai Xia Gao Qian Wang Ying Liu Luhua Lai Jason W. Locasale Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism
description	Serine synthesis from glucose is required even when serine is available from the environment. Here, the authors explain this paradox by showing that the enzyme PHGDH enables nucleotide synthesis by coordinating anabolic fluxes related to central carbon metabolism, independent of its role in serine production.
format	article
author	Michael A. Reid Annamarie E. Allen Shiyu Liu Maria V. Liberti Pei Liu Xiaojing Liu Ziwei Dai Xia Gao Qian Wang Ying Liu Luhua Lai Jason W. Locasale
author_facet	Michael A. Reid Annamarie E. Allen Shiyu Liu Maria V. Liberti Pei Liu Xiaojing Liu Ziwei Dai Xia Gao Qian Wang Ying Liu Luhua Lai Jason W. Locasale
author_sort	Michael A. Reid
title	Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism
title_short	Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism
title_full	Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism
title_fullStr	Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism
title_full_unstemmed	Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism
title_sort	serine synthesis through phgdh coordinates nucleotide levels by maintaining central carbon metabolism
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/570cbf552bdf471ba93d9ee853a1c9f2
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Serine synthesis through PHGDH coordinates nucleotide levels by maintaining central carbon metabolism

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