Impact of serum level of vitamin D on term neonates with early onset sepsis

Abstract Background: Neonatal sepsis a major health challenge associated with major morbidity and mortality. Neonatal care improved recently. However, different challenges regarding management still exist. Vitamin D deficiencies was proposed as a predictor of neonatal sepsis. Objective: To highligh...

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Autores principales:	Yasmine Soliman, Magdy Sakr, Tarek Emran, Mohamed El Samanoudy
Formato:	article
Lenguaje:	EN
Publicado:	Al-Azhar University, Faculty of Medicine (Damietta) 2019
Materias:	keywords: vitamin d neonates sepsis full term Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5713fd8f7f8d46789c809dad4c949db5
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spelling	oai:doaj.org-article:5713fd8f7f8d46789c809dad4c949db52021-12-02T13:52:45ZImpact of serum level of vitamin D on term neonates with early onset sepsis2636-41742682-378010.21608/ijma.2019.12445.1002https://doaj.org/article/5713fd8f7f8d46789c809dad4c949db52019-07-01T00:00:00Zhttps://ijma.journals.ekb.eg/article_34023_0eef55ba7bc75ba15d37303dd62e7255.pdfhttps://doaj.org/toc/2636-4174https://doaj.org/toc/2682-3780Abstract Background: Neonatal sepsis a major health challenge associated with major morbidity and mortality. Neonatal care improved recently. However, different challenges regarding management still exist. Vitamin D deficiencies was proposed as a predictor of neonatal sepsis. Objective: To highlight the impact of vitamin D levels on early onset sepsis in full term neonates. Methodology: It is a case control which carried out at the neonatal intensive care unit of Al-Azhar university hospital (Damietta), from March to April 2019. It included 50 full-term neonates with probable sepsis and 50 healthy controls of matched age and sex with no signs of sepsis. Results: vitamin D level showed significant negative correlation with sepsis, C-reactive protein (CRP), positive blood cultures; and significant positive correlations with Apgar score, hemoglobin concentration and platelets count. Regression analysis revealed that, higher CRP and lower vitamin D were associated risks of neonatal sepsis in univariate analysis. Multivariable regression analysis revealed that only lower vitamin D level is the predictor for early neonatal sepsis. Conclusion: Vitamin D levels were significantly lower in septic neonates with high sensitivity and specificity. Vitamin D supplementation to mothers during pregnancy could prevent early onset neonatal sepsis.Yasmine SolimanMagdy SakrTarek EmranMohamed El SamanoudyAl-Azhar University, Faculty of Medicine (Damietta)articlekeywords: vitamin dneonatessepsisfull termMedicine (General)R5-920ENInternational Journal of Medical Arts, Vol 1, Iss 1, Pp 42-47 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	keywords: vitamin d neonates sepsis full term Medicine (General) R5-920
spellingShingle	keywords: vitamin d neonates sepsis full term Medicine (General) R5-920 Yasmine Soliman Magdy Sakr Tarek Emran Mohamed El Samanoudy Impact of serum level of vitamin D on term neonates with early onset sepsis
description	Abstract Background: Neonatal sepsis a major health challenge associated with major morbidity and mortality. Neonatal care improved recently. However, different challenges regarding management still exist. Vitamin D deficiencies was proposed as a predictor of neonatal sepsis. Objective: To highlight the impact of vitamin D levels on early onset sepsis in full term neonates. Methodology: It is a case control which carried out at the neonatal intensive care unit of Al-Azhar university hospital (Damietta), from March to April 2019. It included 50 full-term neonates with probable sepsis and 50 healthy controls of matched age and sex with no signs of sepsis. Results: vitamin D level showed significant negative correlation with sepsis, C-reactive protein (CRP), positive blood cultures; and significant positive correlations with Apgar score, hemoglobin concentration and platelets count. Regression analysis revealed that, higher CRP and lower vitamin D were associated risks of neonatal sepsis in univariate analysis. Multivariable regression analysis revealed that only lower vitamin D level is the predictor for early neonatal sepsis. Conclusion: Vitamin D levels were significantly lower in septic neonates with high sensitivity and specificity. Vitamin D supplementation to mothers during pregnancy could prevent early onset neonatal sepsis.
format	article
author	Yasmine Soliman Magdy Sakr Tarek Emran Mohamed El Samanoudy
author_facet	Yasmine Soliman Magdy Sakr Tarek Emran Mohamed El Samanoudy
author_sort	Yasmine Soliman
title	Impact of serum level of vitamin D on term neonates with early onset sepsis
title_short	Impact of serum level of vitamin D on term neonates with early onset sepsis
title_full	Impact of serum level of vitamin D on term neonates with early onset sepsis
title_fullStr	Impact of serum level of vitamin D on term neonates with early onset sepsis
title_full_unstemmed	Impact of serum level of vitamin D on term neonates with early onset sepsis
title_sort	impact of serum level of vitamin d on term neonates with early onset sepsis
publisher	Al-Azhar University, Faculty of Medicine (Damietta)
publishDate	2019
url	https://doaj.org/article/5713fd8f7f8d46789c809dad4c949db5
work_keys_str_mv	AT yasminesoliman impactofserumlevelofvitamindontermneonateswithearlyonsetsepsis AT magdysakr impactofserumlevelofvitamindontermneonateswithearlyonsetsepsis AT tarekemran impactofserumlevelofvitamindontermneonateswithearlyonsetsepsis AT mohamedelsamanoudy impactofserumlevelofvitamindontermneonateswithearlyonsetsepsis
_version_	1718392378682769408

Impact of serum level of vitamin D on term neonates with early onset sepsis

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