Beneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis

Introduction Statins are widely used in stroke patients. The AHA/ASA guidelines recommend aggressive statin therapy in atherosclerotic stroke patients. Their beneficial effects are due to both their hypolipemic and pleiotropic properties. The aim of this study was to establish potential benefits fro...

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Autores principales:	Dariusz Kotlęga, Monika Gołąb-Janowska, Agnieszka Meller, Anna Bajer-Czajkowska, Agnieszka Zembroń-Łacny, Przemysław Nowacki, Maciej Banach
Formato:	article
Lenguaje:	EN
Publicado:	Termedia Publishing House 2019
Materias:	stroke outcome atrial fibrillation anticoagulant prophylaxis statin embolism Medicine R
Acceso en línea:	https://doaj.org/article/57144d5a75de4b05ad92b1a0e27a03b7
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spelling	oai:doaj.org-article:57144d5a75de4b05ad92b1a0e27a03b72021-12-02T19:15:49ZBeneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis1734-19221896-915110.5114/aoms.2019.82925https://doaj.org/article/57144d5a75de4b05ad92b1a0e27a03b72019-03-01T00:00:00Zhttps://www.archivesofmedicalscience.com/Beneficial-effects-of-pre-stroke-statins-use-in-cardioembolic-stroke-patients-with,93972,0,2.htmlhttps://doaj.org/toc/1734-1922https://doaj.org/toc/1896-9151Introduction Statins are widely used in stroke patients. The AHA/ASA guidelines recommend aggressive statin therapy in atherosclerotic stroke patients. Their beneficial effects are due to both their hypolipemic and pleiotropic properties. The aim of this study was to establish potential benefits from statin use in ischemic stroke patients with the diagnosis of atrial fibrillation (AF). Material and methods Ischemic stroke patients with AF were enrolled in the study. Group I, the statin group (n = 181), consisted of patients who had been treated with statins before stroke. Group II, the non-statin group (n = 153), consisted of patients who had not received such treatment in the last year. In-hospital mortality and neurological deficit on admission and at discharge were analyzed using the National Institutes of Health Stroke Scale (NIHSS) score. Results Patients from the non-statin group had greater initial and discharge NIHSS scores (10 vs. 11.9, probability value p < 0.05; 7.6 vs. 9.5, p < 0.05 respectively). The improvement in NIHSS score was greater in the statin group (73.5% vs. 59.5%, p < 0.01). In-hospital mortality was more frequent in the non-statin group (9.9% vs. 18.3%, p < 0.05). Conclusions Despite the predominant use of statins in atherothrombotic stroke patients, we demonstrated the beneficial effects of statins in cardioembolic stroke patients. Detailed cardiovascular screening for statin therapy should be carried out in all AF patients with regard to primary and secondary stroke prevention.Dariusz KotlęgaMonika Gołąb-JanowskaAgnieszka MellerAnna Bajer-CzajkowskaAgnieszka Zembroń-ŁacnyPrzemysław NowackiMaciej BanachTermedia Publishing Housearticlestrokeoutcomeatrial fibrillationanticoagulant prophylaxisstatinembolismMedicineRENArchives of Medical Science, Vol 15, Iss 2, Pp 385-392 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	stroke outcome atrial fibrillation anticoagulant prophylaxis statin embolism Medicine R
spellingShingle	stroke outcome atrial fibrillation anticoagulant prophylaxis statin embolism Medicine R Dariusz Kotlęga Monika Gołąb-Janowska Agnieszka Meller Anna Bajer-Czajkowska Agnieszka Zembroń-Łacny Przemysław Nowacki Maciej Banach Beneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis
description	Introduction Statins are widely used in stroke patients. The AHA/ASA guidelines recommend aggressive statin therapy in atherosclerotic stroke patients. Their beneficial effects are due to both their hypolipemic and pleiotropic properties. The aim of this study was to establish potential benefits from statin use in ischemic stroke patients with the diagnosis of atrial fibrillation (AF). Material and methods Ischemic stroke patients with AF were enrolled in the study. Group I, the statin group (n = 181), consisted of patients who had been treated with statins before stroke. Group II, the non-statin group (n = 153), consisted of patients who had not received such treatment in the last year. In-hospital mortality and neurological deficit on admission and at discharge were analyzed using the National Institutes of Health Stroke Scale (NIHSS) score. Results Patients from the non-statin group had greater initial and discharge NIHSS scores (10 vs. 11.9, probability value p < 0.05; 7.6 vs. 9.5, p < 0.05 respectively). The improvement in NIHSS score was greater in the statin group (73.5% vs. 59.5%, p < 0.01). In-hospital mortality was more frequent in the non-statin group (9.9% vs. 18.3%, p < 0.05). Conclusions Despite the predominant use of statins in atherothrombotic stroke patients, we demonstrated the beneficial effects of statins in cardioembolic stroke patients. Detailed cardiovascular screening for statin therapy should be carried out in all AF patients with regard to primary and secondary stroke prevention.
format	article
author	Dariusz Kotlęga Monika Gołąb-Janowska Agnieszka Meller Anna Bajer-Czajkowska Agnieszka Zembroń-Łacny Przemysław Nowacki Maciej Banach
author_facet	Dariusz Kotlęga Monika Gołąb-Janowska Agnieszka Meller Anna Bajer-Czajkowska Agnieszka Zembroń-Łacny Przemysław Nowacki Maciej Banach
author_sort	Dariusz Kotlęga
title	Beneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis
title_short	Beneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis
title_full	Beneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis
title_fullStr	Beneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis
title_full_unstemmed	Beneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis
title_sort	beneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis
publisher	Termedia Publishing House
publishDate	2019
url	https://doaj.org/article/57144d5a75de4b05ad92b1a0e27a03b7
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Beneficial effects of pre-stroke statins use in cardioembolic stroke patients with atrial fibrillation: a hospital-based retrospective analysis

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