The regulatory mechanism of neutrophil extracellular traps in cancer biological behavior

Abstract As the predominant host defense against pathogens, neutrophil extracellular traps (NETs) have attracted increasing attention due to their vital roles in infectious inflammation in the past few years. Interestingly, NETs also play important roles in noninfectious conditions, such as rheumati...

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Autores principales:	Hui Wang, Yiyin Zhang, Qianling Wang, Xiaoli Wei, Hua Wang, Kangsheng Gu
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Neutrophil extracellular traps Cancer Tumor microenvironment Signal pathway Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Biochemistry QD415-436
Acceso en línea:	https://doaj.org/article/5715a467a9054d3098f4356539578b31
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spelling	oai:doaj.org-article:5715a467a9054d3098f4356539578b312021-11-14T12:31:44ZThe regulatory mechanism of neutrophil extracellular traps in cancer biological behavior10.1186/s13578-021-00708-z2045-3701https://doaj.org/article/5715a467a9054d3098f4356539578b312021-11-01T00:00:00Zhttps://doi.org/10.1186/s13578-021-00708-zhttps://doaj.org/toc/2045-3701Abstract As the predominant host defense against pathogens, neutrophil extracellular traps (NETs) have attracted increasing attention due to their vital roles in infectious inflammation in the past few years. Interestingly, NETs also play important roles in noninfectious conditions, such as rheumatism and cancer. The process of NETs formation can be regulated and the form of cell death accompanied by the formation of NETs is regarded as “NETosis”. A large amount of evidence has confirmed that many stimuli can facilitate the release of NETs from neutrophils. Furthermore, it has been illustrated that NETs promote tumor growth and progression via many molecular pathways. Meanwhile, NETs also can promote metastasis in many kinds of cancers based on multiple studies. In addition, some researchs have found that NETs can promote coagulation and cancer-associated thrombosis. In the present review, it will highlight how NETosis, which is stimulated by various stimuli and signaling pathways, affects cancer biological behaviors via NETs. Given their crucial roles in cancer, NETs will become possible therapeutic targets for inhibiting proliferation, metastasis and thrombosis in cancer patients.Hui WangYiyin ZhangQianling WangXiaoli WeiHua WangKangsheng GuBMCarticleNeutrophil extracellular trapsCancerTumor microenvironmentSignal pathwayBiotechnologyTP248.13-248.65Biology (General)QH301-705.5BiochemistryQD415-436ENCell & Bioscience, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neutrophil extracellular traps Cancer Tumor microenvironment Signal pathway Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Biochemistry QD415-436
spellingShingle	Neutrophil extracellular traps Cancer Tumor microenvironment Signal pathway Biotechnology TP248.13-248.65 Biology (General) QH301-705.5 Biochemistry QD415-436 Hui Wang Yiyin Zhang Qianling Wang Xiaoli Wei Hua Wang Kangsheng Gu The regulatory mechanism of neutrophil extracellular traps in cancer biological behavior
description	Abstract As the predominant host defense against pathogens, neutrophil extracellular traps (NETs) have attracted increasing attention due to their vital roles in infectious inflammation in the past few years. Interestingly, NETs also play important roles in noninfectious conditions, such as rheumatism and cancer. The process of NETs formation can be regulated and the form of cell death accompanied by the formation of NETs is regarded as “NETosis”. A large amount of evidence has confirmed that many stimuli can facilitate the release of NETs from neutrophils. Furthermore, it has been illustrated that NETs promote tumor growth and progression via many molecular pathways. Meanwhile, NETs also can promote metastasis in many kinds of cancers based on multiple studies. In addition, some researchs have found that NETs can promote coagulation and cancer-associated thrombosis. In the present review, it will highlight how NETosis, which is stimulated by various stimuli and signaling pathways, affects cancer biological behaviors via NETs. Given their crucial roles in cancer, NETs will become possible therapeutic targets for inhibiting proliferation, metastasis and thrombosis in cancer patients.
format	article
author	Hui Wang Yiyin Zhang Qianling Wang Xiaoli Wei Hua Wang Kangsheng Gu
author_facet	Hui Wang Yiyin Zhang Qianling Wang Xiaoli Wei Hua Wang Kangsheng Gu
author_sort	Hui Wang
title	The regulatory mechanism of neutrophil extracellular traps in cancer biological behavior
title_short	The regulatory mechanism of neutrophil extracellular traps in cancer biological behavior
title_full	The regulatory mechanism of neutrophil extracellular traps in cancer biological behavior
title_fullStr	The regulatory mechanism of neutrophil extracellular traps in cancer biological behavior
title_full_unstemmed	The regulatory mechanism of neutrophil extracellular traps in cancer biological behavior
title_sort	regulatory mechanism of neutrophil extracellular traps in cancer biological behavior
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5715a467a9054d3098f4356539578b31
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The regulatory mechanism of neutrophil extracellular traps in cancer biological behavior

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