Detecting local genetic correlations with scan statistics

Genetic correlation analyses give insight on complex disease, yet are limited by oversimplification. Here, the authors present LOGODetect, a method using summary statistics from genome-wide association studies to identify genomic regions with correlation signals across multiple phenotypes.

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Detalles Bibliográficos
Autores principales:	Hanmin Guo, James J. Li, Qiongshi Lu, Lin Hou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5719480cafa349d680319f99b207e396
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spelling	oai:doaj.org-article:5719480cafa349d680319f99b207e3962021-12-02T13:27:03ZDetecting local genetic correlations with scan statistics10.1038/s41467-021-22334-62041-1723https://doaj.org/article/5719480cafa349d680319f99b207e3962021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22334-6https://doaj.org/toc/2041-1723Genetic correlation analyses give insight on complex disease, yet are limited by oversimplification. Here, the authors present LOGODetect, a method using summary statistics from genome-wide association studies to identify genomic regions with correlation signals across multiple phenotypes.Hanmin GuoJames J. LiQiongshi LuLin HouNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hanmin Guo James J. Li Qiongshi Lu Lin Hou Detecting local genetic correlations with scan statistics
description	Genetic correlation analyses give insight on complex disease, yet are limited by oversimplification. Here, the authors present LOGODetect, a method using summary statistics from genome-wide association studies to identify genomic regions with correlation signals across multiple phenotypes.
format	article
author	Hanmin Guo James J. Li Qiongshi Lu Lin Hou
author_facet	Hanmin Guo James J. Li Qiongshi Lu Lin Hou
author_sort	Hanmin Guo
title	Detecting local genetic correlations with scan statistics
title_short	Detecting local genetic correlations with scan statistics
title_full	Detecting local genetic correlations with scan statistics
title_fullStr	Detecting local genetic correlations with scan statistics
title_full_unstemmed	Detecting local genetic correlations with scan statistics
title_sort	detecting local genetic correlations with scan statistics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5719480cafa349d680319f99b207e396
work_keys_str_mv	AT hanminguo detectinglocalgeneticcorrelationswithscanstatistics AT jamesjli detectinglocalgeneticcorrelationswithscanstatistics AT qiongshilu detectinglocalgeneticcorrelationswithscanstatistics AT linhou detectinglocalgeneticcorrelationswithscanstatistics
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Detecting local genetic correlations with scan statistics

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