The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus

Hang Zhao,1 Yunfeng Zhen,1 Zijing Wang,1 Licui Qi,2 Yong Li,3 Luping Ren,1,* Shuchun Chen1,* 1Endocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei 050051, People’s Republic of China; 2Graduate School of Hebei North University, Zhangjiakou, Hebei 07500, People’s R...

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Autores principales:	Zhao H, Zhen Y, Wang Z, Qi L, Li Y, Ren L, Chen S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	diabetes mellitus type 2 25-hydroxyvitamin d glycated hemoglobin Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/571b032a3aaa48cc90919cd082607cd5
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spelling	oai:doaj.org-article:571b032a3aaa48cc90919cd082607cd52021-12-02T11:11:45ZThe Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus1178-7007https://doaj.org/article/571b032a3aaa48cc90919cd082607cd52020-10-01T00:00:00Zhttps://www.dovepress.com/the-relationship-between-vitamin-d-deficiency-and-glycated-hemoglobin--peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Hang Zhao,1 Yunfeng Zhen,1 Zijing Wang,1 Licui Qi,2 Yong Li,3 Luping Ren,1,* Shuchun Chen1,* 1Endocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei 050051, People’s Republic of China; 2Graduate School of Hebei North University, Zhangjiakou, Hebei 07500, People’s Republic of China; 3Graduate School of North China University of Science and Technology, Caofeidian New Town, Tangshan, Hebei 063210, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuchun ChenEndocrinology Department, Hebei General Hospital, 348, Heping West Road, Shijiazhuang, Hebei 050051, People’s Republic of ChinaEmail guang6701@sina.comLuping RenEndocrinology Department, Hebei General Hospital, 348, Heping West Road, Shijiazhuang, Hebei 050051, People’s Republic of ChinaEmail renluping1122@163.comPurpose: The aims of this study were to determine the relationship between 25-hydroxyvitamin D [25(OH) D] and glycated hemoglobin (HbA1c) levels in male and female patients with type 2 diabetes mellitus (T2DM).Patients and Methods: The participants were adults diagnosed with T2DM recruited from Hebei General Hospital. Patient information and information regarding blood indicators were collected. The subjects were divided into no vitamin D deficiency group [25(OH) D > 20 ng/mL] and vitamin D deficiency group [25(OH) D < 20 ng/mL], and these groups were then further subdivided into male-only or female-only subgroups. And then, the subjects were divided into male group and female group in different 25(OH) D levels.Results: HbA1c levels in the vitamin D deficiency group were significantly higher than those in the no vitamin D deficiency group for all subjects. The same was true for female patients but not for male patients. There was no difference in HbA1c levels between male and female patients with T2DM, regardless of 25(OH) D deficiency. A negative correlation existed between 25(OH) D and HbA1c in all subjects, as well as in the male-only and female-only subgroups. Vitamin D deficiency was associated with high HbA1c levels before and after adjusting for confounding factors in all participants and in the female-only subgroup, but not in the male-only subgroup.Conclusion: This study confirmed that vitamin D deficiency was related with high HbA1c levels in patients with T2DM, and this relationship differs between female and male patients.Keywords: diabetes mellitus, type 2, 25-hydroxyvitamin D, glycated hemoglobinZhao HZhen YWang ZQi LLi YRen LChen SDove Medical Pressarticlediabetes mellitustype 225-hydroxyvitamin dglycated hemoglobinSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 3899-3907 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	diabetes mellitus type 2 25-hydroxyvitamin d glycated hemoglobin Specialties of internal medicine RC581-951
spellingShingle	diabetes mellitus type 2 25-hydroxyvitamin d glycated hemoglobin Specialties of internal medicine RC581-951 Zhao H Zhen Y Wang Z Qi L Li Y Ren L Chen S The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus
description	Hang Zhao,1 Yunfeng Zhen,1 Zijing Wang,1 Licui Qi,2 Yong Li,3 Luping Ren,1,* Shuchun Chen1,* 1Endocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei 050051, People’s Republic of China; 2Graduate School of Hebei North University, Zhangjiakou, Hebei 07500, People’s Republic of China; 3Graduate School of North China University of Science and Technology, Caofeidian New Town, Tangshan, Hebei 063210, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shuchun ChenEndocrinology Department, Hebei General Hospital, 348, Heping West Road, Shijiazhuang, Hebei 050051, People’s Republic of ChinaEmail guang6701@sina.comLuping RenEndocrinology Department, Hebei General Hospital, 348, Heping West Road, Shijiazhuang, Hebei 050051, People’s Republic of ChinaEmail renluping1122@163.comPurpose: The aims of this study were to determine the relationship between 25-hydroxyvitamin D [25(OH) D] and glycated hemoglobin (HbA1c) levels in male and female patients with type 2 diabetes mellitus (T2DM).Patients and Methods: The participants were adults diagnosed with T2DM recruited from Hebei General Hospital. Patient information and information regarding blood indicators were collected. The subjects were divided into no vitamin D deficiency group [25(OH) D > 20 ng/mL] and vitamin D deficiency group [25(OH) D < 20 ng/mL], and these groups were then further subdivided into male-only or female-only subgroups. And then, the subjects were divided into male group and female group in different 25(OH) D levels.Results: HbA1c levels in the vitamin D deficiency group were significantly higher than those in the no vitamin D deficiency group for all subjects. The same was true for female patients but not for male patients. There was no difference in HbA1c levels between male and female patients with T2DM, regardless of 25(OH) D deficiency. A negative correlation existed between 25(OH) D and HbA1c in all subjects, as well as in the male-only and female-only subgroups. Vitamin D deficiency was associated with high HbA1c levels before and after adjusting for confounding factors in all participants and in the female-only subgroup, but not in the male-only subgroup.Conclusion: This study confirmed that vitamin D deficiency was related with high HbA1c levels in patients with T2DM, and this relationship differs between female and male patients.Keywords: diabetes mellitus, type 2, 25-hydroxyvitamin D, glycated hemoglobin
format	article
author	Zhao H Zhen Y Wang Z Qi L Li Y Ren L Chen S
author_facet	Zhao H Zhen Y Wang Z Qi L Li Y Ren L Chen S
author_sort	Zhao H
title	The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus
title_short	The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus
title_full	The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus
title_fullStr	The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus
title_full_unstemmed	The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus
title_sort	relationship between vitamin d deficiency and glycated hemoglobin levels in patients with type 2 diabetes mellitus
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/571b032a3aaa48cc90919cd082607cd5
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The Relationship Between Vitamin D Deficiency and Glycated Hemoglobin Levels in Patients with Type 2 Diabetes Mellitus

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