Can Dietary Fatty Acids Affect the COVID-19 Infection Outcome in Vulnerable Populations?

ABSTRACT There is high mortality in coronavirus disease 2019 (COVID-19)-infected individuals with chronic inflammatory diseases, like obesity, diabetes, and hypertension. A cytokine storm in some patients after infection contributes to this mortality. In addition to lungs, the intestine is targeted...

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Autores principales:	J. C. Onishi, M. M. Häggblom, S. A. Shapses
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2020
Materias:	COVID-19 cytokine storm diet endotoxin gut bacteria intestine Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/571d1305e9e646bba4fbbcbba41b75f9
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id	oai:doaj.org-article:571d1305e9e646bba4fbbcbba41b75f9
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spelling	oai:doaj.org-article:571d1305e9e646bba4fbbcbba41b75f92021-11-15T15:56:45ZCan Dietary Fatty Acids Affect the COVID-19 Infection Outcome in Vulnerable Populations?10.1128/mBio.01723-202150-7511https://doaj.org/article/571d1305e9e646bba4fbbcbba41b75f92020-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01723-20https://doaj.org/toc/2150-7511ABSTRACT There is high mortality in coronavirus disease 2019 (COVID-19)-infected individuals with chronic inflammatory diseases, like obesity, diabetes, and hypertension. A cytokine storm in some patients after infection contributes to this mortality. In addition to lungs, the intestine is targeted during COVID-19 infection. The intestinal membrane serves as a barrier to prevent leakage of microorganisms and their products into the bloodstream; however, dietary fats can affect the gut microbiome and may increase intestinal permeability. In obese or diabetic individuals, there is an increase in the abundance of either Gram-negative bacteria in the gut or their product, endotoxin, in systemic circulation. We speculate that when the COVID-19 infection localizes in the intestine and when the permeability properties of the intestinal membrane are compromised, an inflammatory response is generated when proinflammatory endotoxin, produced by resident Gram-negative bacteria, leaks into the systemic circulation. This review discusses conditions contributing to inflammation that are triggered by microbially derived factors from the gut.J. C. OnishiM. M. HäggblomS. A. ShapsesAmerican Society for MicrobiologyarticleCOVID-19cytokine stormdietendotoxingut bacteriaintestineMicrobiologyQR1-502ENmBio, Vol 11, Iss 4 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19 cytokine storm diet endotoxin gut bacteria intestine Microbiology QR1-502
spellingShingle	COVID-19 cytokine storm diet endotoxin gut bacteria intestine Microbiology QR1-502 J. C. Onishi M. M. Häggblom S. A. Shapses Can Dietary Fatty Acids Affect the COVID-19 Infection Outcome in Vulnerable Populations?
description	ABSTRACT There is high mortality in coronavirus disease 2019 (COVID-19)-infected individuals with chronic inflammatory diseases, like obesity, diabetes, and hypertension. A cytokine storm in some patients after infection contributes to this mortality. In addition to lungs, the intestine is targeted during COVID-19 infection. The intestinal membrane serves as a barrier to prevent leakage of microorganisms and their products into the bloodstream; however, dietary fats can affect the gut microbiome and may increase intestinal permeability. In obese or diabetic individuals, there is an increase in the abundance of either Gram-negative bacteria in the gut or their product, endotoxin, in systemic circulation. We speculate that when the COVID-19 infection localizes in the intestine and when the permeability properties of the intestinal membrane are compromised, an inflammatory response is generated when proinflammatory endotoxin, produced by resident Gram-negative bacteria, leaks into the systemic circulation. This review discusses conditions contributing to inflammation that are triggered by microbially derived factors from the gut.
format	article
author	J. C. Onishi M. M. Häggblom S. A. Shapses
author_facet	J. C. Onishi M. M. Häggblom S. A. Shapses
author_sort	J. C. Onishi
title	Can Dietary Fatty Acids Affect the COVID-19 Infection Outcome in Vulnerable Populations?
title_short	Can Dietary Fatty Acids Affect the COVID-19 Infection Outcome in Vulnerable Populations?
title_full	Can Dietary Fatty Acids Affect the COVID-19 Infection Outcome in Vulnerable Populations?
title_fullStr	Can Dietary Fatty Acids Affect the COVID-19 Infection Outcome in Vulnerable Populations?
title_full_unstemmed	Can Dietary Fatty Acids Affect the COVID-19 Infection Outcome in Vulnerable Populations?
title_sort	can dietary fatty acids affect the covid-19 infection outcome in vulnerable populations?
publisher	American Society for Microbiology
publishDate	2020
url	https://doaj.org/article/571d1305e9e646bba4fbbcbba41b75f9
work_keys_str_mv	AT jconishi candietaryfattyacidsaffectthecovid19infectionoutcomeinvulnerablepopulations AT mmhaggblom candietaryfattyacidsaffectthecovid19infectionoutcomeinvulnerablepopulations AT sashapses candietaryfattyacidsaffectthecovid19infectionoutcomeinvulnerablepopulations
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Can Dietary Fatty Acids Affect the COVID-19 Infection Outcome in Vulnerable Populations?

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