Role of Predonation Hydration in the Prevention of Postdonation Vasovagal Reactions in First Time Blood Donors: A Randomised Controlled Trial
Introduction: A crucial component of the effort to meet the growing demand for blood is the recruitment and retention of young novice blood donors. Reducing postdonation syncopal reactions could have a beneficial impact on donor convenience, safety, and desire to donate again. Aim: To evaluate...
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| Autores principales: | , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
JCDR Research and Publications Private Limited
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/57201ffcf265468a93867016e8864276 |
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| Sumario: | Introduction: A crucial component of the effort to meet the
growing demand for blood is the recruitment and retention of
young novice blood donors. Reducing postdonation syncopal
reactions could have a beneficial impact on donor convenience,
safety, and desire to donate again.
Aim: To evaluate the effectiveness of predonation hydration
over standard blood donation in the prevention or decrease in
severity of postdonation Vasovagal Reactions (VVR) in hydrated
blood donors in comparison with the non hydrated group.
Materials and Methods: The randomised controlled trial was
conducted on 953 first time voluntary blood donors. Donors
in the intervention arm drank 250 mL water 30 minutes before
blood donation, while those in the control group did not receive
any intervention. Blood was collected by standard protocol.
Outcome, VVR, if present was graded as mild, moderate, and
severe. Analysis of results were done using Statistical Package
for the Social Sciences (SPSS) version 16.0. A sensitivity analysis
was also done to consider the dropouts from the study.
Results: A total of 900 participants were included in the study,
of which 443 were controls and 457 were cases. An effect
size of 6.1%, a Relative Risk (RR) of 0.54 {95% Confidence
Interval (CI)=0.36-0.81} and a risk reduction of 45% was arrived
at, pointing to a protective role for predonation hydration in
preventing VVR. There was a significant reduction in the severity
of VVR in the predonation hydration group compared to the
standard blood donation group (p-value=0.002). The protective
effect of hydration on decreasing the occurrence and severity of
VVR had statistical support in males in the moderate and severe
grades (p-value=0.017). A similar statistical significance was not
established in females (p-value=0.173). Sensitivity analysis did
not reveal a difference in the statistical significance of variables
between compared groups.
Conclusion: Predonation hydration was found to be effective
in preventing and decreasing the severity of VVR in novice
blood donors. |
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