Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy

Abstract The Wingless (Wnt) pathway has been implicated in the pathogenesis of dilated cardiomyopathy (DCM). To explore the role of Wnt modulators Wnt5a and sFRP3 in DCM patients we analyzed the expression of Wnt5a and sFRP3 in plasma and myocardium of DCM patients and evaluated their effects on NFA...

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Autores principales:	Aurelija Abraityte, Ida G. Lunde, Erik T. Askevold, Annika E. Michelsen, Geir Christensen, Pål Aukrust, Arne Yndestad, Arnt Fiane, Arne Andreassen, Svend Aakhus, Christen P. Dahl, Lars Gullestad, Kaspar Broch, Thor Ueland
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/572165425058480c879552c9e58ac6e1
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spelling	oai:doaj.org-article:572165425058480c879552c9e58ac6e12021-12-02T15:06:22ZWnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy10.1038/s41598-017-03625-92045-2322https://doaj.org/article/572165425058480c879552c9e58ac6e12017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03625-9https://doaj.org/toc/2045-2322Abstract The Wingless (Wnt) pathway has been implicated in the pathogenesis of dilated cardiomyopathy (DCM). To explore the role of Wnt modulators Wnt5a and sFRP3 in DCM patients we analyzed the expression of Wnt5a and sFRP3 in plasma and myocardium of DCM patients and evaluated their effects on NFAT luciferase activity in neonatal mouse cardiomyocytes. Elevated circulating Wnt5a (n = 102) was associated with increased pulmonary artery pressures, decreased right ventricular function and adverse outcome, with a stronger association in more severely affected patients. A higher Wnt5a/sFRP3 ratio (n = 25) was found in the right ventricle vs. the left ventricle and was correlated with NFAT activation as well as pulmonary artery pressures. Wnt5a induced NFAT activation and sFRP3 release in cardiomyocytes in vitro, while sFRP3 antagonized Wnt5a. Wnt5a is associated with right ventricular dysfunction and adverse outcome in DCM patients and may promote the progression of DCM through NFAT signaling.Aurelija AbraityteIda G. LundeErik T. AskevoldAnnika E. MichelsenGeir ChristensenPål AukrustArne YndestadArnt FianeArne AndreassenSvend AakhusChristen P. DahlLars GullestadKaspar BrochThor UelandNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aurelija Abraityte Ida G. Lunde Erik T. Askevold Annika E. Michelsen Geir Christensen Pål Aukrust Arne Yndestad Arnt Fiane Arne Andreassen Svend Aakhus Christen P. Dahl Lars Gullestad Kaspar Broch Thor Ueland Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
description	Abstract The Wingless (Wnt) pathway has been implicated in the pathogenesis of dilated cardiomyopathy (DCM). To explore the role of Wnt modulators Wnt5a and sFRP3 in DCM patients we analyzed the expression of Wnt5a and sFRP3 in plasma and myocardium of DCM patients and evaluated their effects on NFAT luciferase activity in neonatal mouse cardiomyocytes. Elevated circulating Wnt5a (n = 102) was associated with increased pulmonary artery pressures, decreased right ventricular function and adverse outcome, with a stronger association in more severely affected patients. A higher Wnt5a/sFRP3 ratio (n = 25) was found in the right ventricle vs. the left ventricle and was correlated with NFAT activation as well as pulmonary artery pressures. Wnt5a induced NFAT activation and sFRP3 release in cardiomyocytes in vitro, while sFRP3 antagonized Wnt5a. Wnt5a is associated with right ventricular dysfunction and adverse outcome in DCM patients and may promote the progression of DCM through NFAT signaling.
format	article
author	Aurelija Abraityte Ida G. Lunde Erik T. Askevold Annika E. Michelsen Geir Christensen Pål Aukrust Arne Yndestad Arnt Fiane Arne Andreassen Svend Aakhus Christen P. Dahl Lars Gullestad Kaspar Broch Thor Ueland
author_facet	Aurelija Abraityte Ida G. Lunde Erik T. Askevold Annika E. Michelsen Geir Christensen Pål Aukrust Arne Yndestad Arnt Fiane Arne Andreassen Svend Aakhus Christen P. Dahl Lars Gullestad Kaspar Broch Thor Ueland
author_sort	Aurelija Abraityte
title	Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
title_short	Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
title_full	Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
title_fullStr	Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
title_full_unstemmed	Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
title_sort	wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/572165425058480c879552c9e58ac6e1
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Wnt5a is associated with right ventricular dysfunction and adverse outcome in dilated cardiomyopathy

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