Biomechanical characterization of the passive response of the thoracic aorta in chronic hypoxic newborn lambs using an evolutionary strategy

Abstract The present study involves experiments and modelling aimed at characterizing the passive structural mechanical behavior of the chronic hypoxic lamb thoracic aorta, whose gestation, birth and postnatal period were carried at high altitude (3600 masl). To this end, the mechanical response was...

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Autores principales:	Eugenio Rivera, Claudio Canales, Matías Pacheco, Claudio García-Herrera, Demetrio Macías, Diego J. Celentano, Emilio A. Herrera
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5721c5dd1ee64d9aa011082b4068007b
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spelling	oai:doaj.org-article:5721c5dd1ee64d9aa011082b4068007b2021-12-02T18:34:20ZBiomechanical characterization of the passive response of the thoracic aorta in chronic hypoxic newborn lambs using an evolutionary strategy10.1038/s41598-021-93267-92045-2322https://doaj.org/article/5721c5dd1ee64d9aa011082b4068007b2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93267-9https://doaj.org/toc/2045-2322Abstract The present study involves experiments and modelling aimed at characterizing the passive structural mechanical behavior of the chronic hypoxic lamb thoracic aorta, whose gestation, birth and postnatal period were carried at high altitude (3600 masl). To this end, the mechanical response was studied via tensile and pressurization tests. The tensile and pressurization tests measurements were used simultaneously to calibrate the material parameters of the Gasser–Holzapfel–Ogden (GHO) hyperelasctic anisotropic constitutive model through an analytical-numerical optimization procedure solved with an evolutionary strategy that guarantees a stable response of the model. The model and procedure of calibration adequately adjust to the material behavior in a wide deformation range with an appropriate physical description. The results of this study predict the mechanical response of the lamb thoracic aorta under generalized loading states like those that can occur in physiological conditions and/or in systemic arterial hypertension. Finally, the novel use of the evolutionary strategy, together with the set of experiments and tools used in this study, provide a robust alternative to validate biomechanical characterizations.Eugenio RiveraClaudio CanalesMatías PachecoClaudio García-HerreraDemetrio MacíasDiego J. CelentanoEmilio A. HerreraNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Eugenio Rivera Claudio Canales Matías Pacheco Claudio García-Herrera Demetrio Macías Diego J. Celentano Emilio A. Herrera Biomechanical characterization of the passive response of the thoracic aorta in chronic hypoxic newborn lambs using an evolutionary strategy
description	Abstract The present study involves experiments and modelling aimed at characterizing the passive structural mechanical behavior of the chronic hypoxic lamb thoracic aorta, whose gestation, birth and postnatal period were carried at high altitude (3600 masl). To this end, the mechanical response was studied via tensile and pressurization tests. The tensile and pressurization tests measurements were used simultaneously to calibrate the material parameters of the Gasser–Holzapfel–Ogden (GHO) hyperelasctic anisotropic constitutive model through an analytical-numerical optimization procedure solved with an evolutionary strategy that guarantees a stable response of the model. The model and procedure of calibration adequately adjust to the material behavior in a wide deformation range with an appropriate physical description. The results of this study predict the mechanical response of the lamb thoracic aorta under generalized loading states like those that can occur in physiological conditions and/or in systemic arterial hypertension. Finally, the novel use of the evolutionary strategy, together with the set of experiments and tools used in this study, provide a robust alternative to validate biomechanical characterizations.
format	article
author	Eugenio Rivera Claudio Canales Matías Pacheco Claudio García-Herrera Demetrio Macías Diego J. Celentano Emilio A. Herrera
author_facet	Eugenio Rivera Claudio Canales Matías Pacheco Claudio García-Herrera Demetrio Macías Diego J. Celentano Emilio A. Herrera
author_sort	Eugenio Rivera
title	Biomechanical characterization of the passive response of the thoracic aorta in chronic hypoxic newborn lambs using an evolutionary strategy
title_short	Biomechanical characterization of the passive response of the thoracic aorta in chronic hypoxic newborn lambs using an evolutionary strategy
title_full	Biomechanical characterization of the passive response of the thoracic aorta in chronic hypoxic newborn lambs using an evolutionary strategy
title_fullStr	Biomechanical characterization of the passive response of the thoracic aorta in chronic hypoxic newborn lambs using an evolutionary strategy
title_full_unstemmed	Biomechanical characterization of the passive response of the thoracic aorta in chronic hypoxic newborn lambs using an evolutionary strategy
title_sort	biomechanical characterization of the passive response of the thoracic aorta in chronic hypoxic newborn lambs using an evolutionary strategy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5721c5dd1ee64d9aa011082b4068007b
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Biomechanical characterization of the passive response of the thoracic aorta in chronic hypoxic newborn lambs using an evolutionary strategy

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