From the intestinal mucosal barrier to the enteric neuromuscular compartment: an integrated overview on the morphological changes in Parkinson’s disease

Gastrointestinal dysfunctions represent the most common non-motor symptoms in Parkinson’s disease (PD). Of note, changes in gut microbiota, impairments of intestinal epithelial barrier (IEB), bowel inflammation and neuroplastic rearrangements of the enteric nervous system (ENS) could be involved in...

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Autores principales:	Carolina Pellegrini, Vanessa D'Antongiovanni, Chiara Ippolito, Cristina Segnani, Luca Antonioli, Matteo Fornai, Nunzia Bernardini
Formato:	article
Lenguaje:	EN
Publicado:	PAGEPress Publications 2021
Materias:	intestinal epithelial barrier enteric nervous system neuromuscular compartment patients animal models Parkinson’s disease Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5722abb7ba724b9a9069a0087edf0e5a
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spelling	oai:doaj.org-article:5722abb7ba724b9a9069a0087edf0e5a2021-11-22T07:51:00ZFrom the intestinal mucosal barrier to the enteric neuromuscular compartment: an integrated overview on the morphological changes in Parkinson’s disease10.4081/ejh.2021.32781121-760X2038-8306https://doaj.org/article/5722abb7ba724b9a9069a0087edf0e5a2021-11-01T00:00:00Zhttps://www.ejh.it/index.php/ejh/article/view/3278https://doaj.org/toc/1121-760Xhttps://doaj.org/toc/2038-8306 Gastrointestinal dysfunctions represent the most common non-motor symptoms in Parkinson’s disease (PD). Of note, changes in gut microbiota, impairments of intestinal epithelial barrier (IEB), bowel inflammation and neuroplastic rearrangements of the enteric nervous system (ENS) could be involved in the pathophysiology of the intestinal disturbances in PD. In this context, although several review articles have pooled together evidence on the alterations of enteric bacteria-neuro-immune network in PD, a revision of the literature on the specific morphological changes occurring in the intestinal mucosal barrier, the ENS and enteric muscular layers in PD, is lacking. The present review provides a complete appraisal of the available knowledge on the morphological alterations of intestinal mucosal barrier, with particular focus on IEB, ENS and enteric muscular layers in PD. In particular, our intent was to critically discuss whether, based on evidence from translational studies and pre-clinical models, morphological changes in the intestinal barrier and enteric neuromuscular compartment contribute to the pathophysiology of intestinal dysfunctions occurring in PD. Carolina PellegriniVanessa D'AntongiovanniChiara IppolitoCristina SegnaniLuca AntonioliMatteo FornaiNunzia BernardiniPAGEPress Publicationsarticleintestinal epithelial barrierenteric nervous systemneuromuscular compartmentpatientsanimal modelsParkinson’s diseaseBiology (General)QH301-705.5ENEuropean Journal of Histochemistry , Vol 65, Iss s1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	intestinal epithelial barrier enteric nervous system neuromuscular compartment patients animal models Parkinson’s disease Biology (General) QH301-705.5
spellingShingle	intestinal epithelial barrier enteric nervous system neuromuscular compartment patients animal models Parkinson’s disease Biology (General) QH301-705.5 Carolina Pellegrini Vanessa D'Antongiovanni Chiara Ippolito Cristina Segnani Luca Antonioli Matteo Fornai Nunzia Bernardini From the intestinal mucosal barrier to the enteric neuromuscular compartment: an integrated overview on the morphological changes in Parkinson’s disease
description	Gastrointestinal dysfunctions represent the most common non-motor symptoms in Parkinson’s disease (PD). Of note, changes in gut microbiota, impairments of intestinal epithelial barrier (IEB), bowel inflammation and neuroplastic rearrangements of the enteric nervous system (ENS) could be involved in the pathophysiology of the intestinal disturbances in PD. In this context, although several review articles have pooled together evidence on the alterations of enteric bacteria-neuro-immune network in PD, a revision of the literature on the specific morphological changes occurring in the intestinal mucosal barrier, the ENS and enteric muscular layers in PD, is lacking. The present review provides a complete appraisal of the available knowledge on the morphological alterations of intestinal mucosal barrier, with particular focus on IEB, ENS and enteric muscular layers in PD. In particular, our intent was to critically discuss whether, based on evidence from translational studies and pre-clinical models, morphological changes in the intestinal barrier and enteric neuromuscular compartment contribute to the pathophysiology of intestinal dysfunctions occurring in PD.
format	article
author	Carolina Pellegrini Vanessa D'Antongiovanni Chiara Ippolito Cristina Segnani Luca Antonioli Matteo Fornai Nunzia Bernardini
author_facet	Carolina Pellegrini Vanessa D'Antongiovanni Chiara Ippolito Cristina Segnani Luca Antonioli Matteo Fornai Nunzia Bernardini
author_sort	Carolina Pellegrini
title	From the intestinal mucosal barrier to the enteric neuromuscular compartment: an integrated overview on the morphological changes in Parkinson’s disease
title_short	From the intestinal mucosal barrier to the enteric neuromuscular compartment: an integrated overview on the morphological changes in Parkinson’s disease
title_full	From the intestinal mucosal barrier to the enteric neuromuscular compartment: an integrated overview on the morphological changes in Parkinson’s disease
title_fullStr	From the intestinal mucosal barrier to the enteric neuromuscular compartment: an integrated overview on the morphological changes in Parkinson’s disease
title_full_unstemmed	From the intestinal mucosal barrier to the enteric neuromuscular compartment: an integrated overview on the morphological changes in Parkinson’s disease
title_sort	from the intestinal mucosal barrier to the enteric neuromuscular compartment: an integrated overview on the morphological changes in parkinson’s disease
publisher	PAGEPress Publications
publishDate	2021
url	https://doaj.org/article/5722abb7ba724b9a9069a0087edf0e5a
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From the intestinal mucosal barrier to the enteric neuromuscular compartment: an integrated overview on the morphological changes in Parkinson’s disease

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