Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke

The effects of thrombolysis therapy in stroke on structural connectivity are not well understood. Here, the authors show with causal mediation analysis that the clinical benefits of thrombolysis in anterior circulation stroke are mediated via structural connectivity.

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Autores principales:	Eckhard Schlemm, Thies Ingwersen, Alina Königsberg, Florent Boutitie, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Jens Fiehler, Ivana Galinovic, Robin Lemmens, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Josep Puig, Claus Z. Simonsen, Vincent Thijs, Anke Wouters, Christian Gerloff, Götz Thomalla, Bastian Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/57258b4e8c144513a87b692fc69385cf
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spelling	oai:doaj.org-article:57258b4e8c144513a87b692fc69385cf2021-12-02T16:57:56ZPreserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke10.1038/s41467-021-22786-w2041-1723https://doaj.org/article/57258b4e8c144513a87b692fc69385cf2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22786-whttps://doaj.org/toc/2041-1723The effects of thrombolysis therapy in stroke on structural connectivity are not well understood. Here, the authors show with causal mediation analysis that the clinical benefits of thrombolysis in anterior circulation stroke are mediated via structural connectivity.Eckhard SchlemmThies IngwersenAlina KönigsbergFlorent BoutitieMartin EbingerMatthias EndresJochen B. FiebachJens FiehlerIvana GalinovicRobin LemmensKeith W. MuirNorbert NighoghossianSalvador PedrazaJosep PuigClaus Z. SimonsenVincent ThijsAnke WoutersChristian GerloffGötz ThomallaBastian ChengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Eckhard Schlemm Thies Ingwersen Alina Königsberg Florent Boutitie Martin Ebinger Matthias Endres Jochen B. Fiebach Jens Fiehler Ivana Galinovic Robin Lemmens Keith W. Muir Norbert Nighoghossian Salvador Pedraza Josep Puig Claus Z. Simonsen Vincent Thijs Anke Wouters Christian Gerloff Götz Thomalla Bastian Cheng Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke
description	The effects of thrombolysis therapy in stroke on structural connectivity are not well understood. Here, the authors show with causal mediation analysis that the clinical benefits of thrombolysis in anterior circulation stroke are mediated via structural connectivity.
format	article
author	Eckhard Schlemm Thies Ingwersen Alina Königsberg Florent Boutitie Martin Ebinger Matthias Endres Jochen B. Fiebach Jens Fiehler Ivana Galinovic Robin Lemmens Keith W. Muir Norbert Nighoghossian Salvador Pedraza Josep Puig Claus Z. Simonsen Vincent Thijs Anke Wouters Christian Gerloff Götz Thomalla Bastian Cheng
author_facet	Eckhard Schlemm Thies Ingwersen Alina Königsberg Florent Boutitie Martin Ebinger Matthias Endres Jochen B. Fiebach Jens Fiehler Ivana Galinovic Robin Lemmens Keith W. Muir Norbert Nighoghossian Salvador Pedraza Josep Puig Claus Z. Simonsen Vincent Thijs Anke Wouters Christian Gerloff Götz Thomalla Bastian Cheng
author_sort	Eckhard Schlemm
title	Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke
title_short	Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke
title_full	Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke
title_fullStr	Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke
title_full_unstemmed	Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke
title_sort	preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/57258b4e8c144513a87b692fc69385cf
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Preserved structural connectivity mediates the clinical effect of thrombolysis in patients with anterior-circulation stroke

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