Effect of a bioconverted product of Lotus corniculatus seed on the axillary microbiome and body odor

Abstract The skin microbiome, especially the axillary microbiome, consists of odor-causing bacteria that decompose odorless sweat into malodor compounds, which contributes to the formation of body odor. Plant-derived products are a cheap source of bioactive compounds that are common ingredients in c...

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Autores principales:	Min-Ji Kim, Setu Bazie Tagele, HyungWoo Jo, Min-Chul Kim, YeonGyun Jung, Yeong-Jun Park, Jai-Hyun So, Hae Jin Kim, Ho Jin Kim, Dong-Geol Lee, Seunghyun Kang, Jae-Ho Shin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/57273f809e2d439b818b544e00b4873b
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spelling	oai:doaj.org-article:57273f809e2d439b818b544e00b4873b2021-12-02T16:50:36ZEffect of a bioconverted product of Lotus corniculatus seed on the axillary microbiome and body odor10.1038/s41598-021-89606-52045-2322https://doaj.org/article/57273f809e2d439b818b544e00b4873b2021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-89606-5https://doaj.org/toc/2045-2322Abstract The skin microbiome, especially the axillary microbiome, consists of odor-causing bacteria that decompose odorless sweat into malodor compounds, which contributes to the formation of body odor. Plant-derived products are a cheap source of bioactive compounds that are common ingredients in cosmetics. Microbial bioconversion of natural products is an ecofriendly and economical method for production of new or improved biologically active compounds. Therefore, in this study, we tested the potential of a Lactobacillus acidophilus KNU-02-mediated bioconverted product (BLC) of Lotus corniculatus seed to reduce axillary malodor and its effect on the associated axillary microbiota. A chemical profile analysis revealed that benzoic acid was the most abundant chemical compound in BLC, which increased following bioconversion. Moreover, BLC treatment was found to reduce the intensity of axillary malodor. We tested the axillary microbiome of 18 study participants, divided equally into BLC and placebo groups, and revealed through 16S rRNA gene sequencing that Staphylococcus, Corynebacterium, and Anaerococcus were the dominant taxa, and some of these taxa were significantly associated with axillary malodor. After one week of BLC treatment, the abundance of Corynebacterium and Anaerococcus, which are associated with well-known odor-related genes that produce volatile fatty acids, had significantly reduced. Likewise, the identified odor-related genes decreased after the application of BLC. BLC treatment enhanced the richness and network density of the axillary microbial community. The placebo group, on the other hand, showed no difference in the microbial richness, odor associated taxa, and predicted functional genes after a week. The results demonstrated that BLC has the potential to reduce the axillary malodor and the associated odor-causing bacteria, which makes BLC a viable deodorant material in cosmetic products.Min-Ji KimSetu Bazie TageleHyungWoo JoMin-Chul KimYeonGyun JungYeong-Jun ParkJai-Hyun SoHae Jin KimHo Jin KimDong-Geol LeeSeunghyun KangJae-Ho ShinNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Min-Ji Kim Setu Bazie Tagele HyungWoo Jo Min-Chul Kim YeonGyun Jung Yeong-Jun Park Jai-Hyun So Hae Jin Kim Ho Jin Kim Dong-Geol Lee Seunghyun Kang Jae-Ho Shin Effect of a bioconverted product of Lotus corniculatus seed on the axillary microbiome and body odor
description	Abstract The skin microbiome, especially the axillary microbiome, consists of odor-causing bacteria that decompose odorless sweat into malodor compounds, which contributes to the formation of body odor. Plant-derived products are a cheap source of bioactive compounds that are common ingredients in cosmetics. Microbial bioconversion of natural products is an ecofriendly and economical method for production of new or improved biologically active compounds. Therefore, in this study, we tested the potential of a Lactobacillus acidophilus KNU-02-mediated bioconverted product (BLC) of Lotus corniculatus seed to reduce axillary malodor and its effect on the associated axillary microbiota. A chemical profile analysis revealed that benzoic acid was the most abundant chemical compound in BLC, which increased following bioconversion. Moreover, BLC treatment was found to reduce the intensity of axillary malodor. We tested the axillary microbiome of 18 study participants, divided equally into BLC and placebo groups, and revealed through 16S rRNA gene sequencing that Staphylococcus, Corynebacterium, and Anaerococcus were the dominant taxa, and some of these taxa were significantly associated with axillary malodor. After one week of BLC treatment, the abundance of Corynebacterium and Anaerococcus, which are associated with well-known odor-related genes that produce volatile fatty acids, had significantly reduced. Likewise, the identified odor-related genes decreased after the application of BLC. BLC treatment enhanced the richness and network density of the axillary microbial community. The placebo group, on the other hand, showed no difference in the microbial richness, odor associated taxa, and predicted functional genes after a week. The results demonstrated that BLC has the potential to reduce the axillary malodor and the associated odor-causing bacteria, which makes BLC a viable deodorant material in cosmetic products.
format	article
author	Min-Ji Kim Setu Bazie Tagele HyungWoo Jo Min-Chul Kim YeonGyun Jung Yeong-Jun Park Jai-Hyun So Hae Jin Kim Ho Jin Kim Dong-Geol Lee Seunghyun Kang Jae-Ho Shin
author_facet	Min-Ji Kim Setu Bazie Tagele HyungWoo Jo Min-Chul Kim YeonGyun Jung Yeong-Jun Park Jai-Hyun So Hae Jin Kim Ho Jin Kim Dong-Geol Lee Seunghyun Kang Jae-Ho Shin
author_sort	Min-Ji Kim
title	Effect of a bioconverted product of Lotus corniculatus seed on the axillary microbiome and body odor
title_short	Effect of a bioconverted product of Lotus corniculatus seed on the axillary microbiome and body odor
title_full	Effect of a bioconverted product of Lotus corniculatus seed on the axillary microbiome and body odor
title_fullStr	Effect of a bioconverted product of Lotus corniculatus seed on the axillary microbiome and body odor
title_full_unstemmed	Effect of a bioconverted product of Lotus corniculatus seed on the axillary microbiome and body odor
title_sort	effect of a bioconverted product of lotus corniculatus seed on the axillary microbiome and body odor
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/57273f809e2d439b818b544e00b4873b
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Effect of a bioconverted product of Lotus corniculatus seed on the axillary microbiome and body odor

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