The Emerging Roles of Autophagy in Human Diseases

Autophagy, a process of cellular self-digestion, delivers intracellular components including superfluous and dysfunctional proteins and organelles to the lysosome for degradation and recycling and is important to maintain cellular homeostasis. In recent decades, autophagy has been found to help figh...

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Autores principales:	Yuchen Lei, Daniel J. Klionsky
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	autophagy cancer infection metabolism neurodegeneration Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/5727582255894113b96780b9d9dd2df8
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spelling	oai:doaj.org-article:5727582255894113b96780b9d9dd2df82021-11-25T16:50:13ZThe Emerging Roles of Autophagy in Human Diseases10.3390/biomedicines91116512227-9059https://doaj.org/article/5727582255894113b96780b9d9dd2df82021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1651https://doaj.org/toc/2227-9059Autophagy, a process of cellular self-digestion, delivers intracellular components including superfluous and dysfunctional proteins and organelles to the lysosome for degradation and recycling and is important to maintain cellular homeostasis. In recent decades, autophagy has been found to help fight against a variety of human diseases, but, at the same time, autophagy can also promote the procession of certain pathologies, which makes the connection between autophagy and diseases complex but interesting. In this review, we summarize the advances in understanding the roles of autophagy in human diseases and the therapeutic methods targeting autophagy and discuss some of the remaining questions in this field, focusing on cancer, neurodegenerative diseases, infectious diseases and metabolic disorders.Yuchen LeiDaniel J. KlionskyMDPI AGarticleautophagycancerinfectionmetabolismneurodegenerationBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1651, p 1651 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	autophagy cancer infection metabolism neurodegeneration Biology (General) QH301-705.5
spellingShingle	autophagy cancer infection metabolism neurodegeneration Biology (General) QH301-705.5 Yuchen Lei Daniel J. Klionsky The Emerging Roles of Autophagy in Human Diseases
description	Autophagy, a process of cellular self-digestion, delivers intracellular components including superfluous and dysfunctional proteins and organelles to the lysosome for degradation and recycling and is important to maintain cellular homeostasis. In recent decades, autophagy has been found to help fight against a variety of human diseases, but, at the same time, autophagy can also promote the procession of certain pathologies, which makes the connection between autophagy and diseases complex but interesting. In this review, we summarize the advances in understanding the roles of autophagy in human diseases and the therapeutic methods targeting autophagy and discuss some of the remaining questions in this field, focusing on cancer, neurodegenerative diseases, infectious diseases and metabolic disorders.
format	article
author	Yuchen Lei Daniel J. Klionsky
author_facet	Yuchen Lei Daniel J. Klionsky
author_sort	Yuchen Lei
title	The Emerging Roles of Autophagy in Human Diseases
title_short	The Emerging Roles of Autophagy in Human Diseases
title_full	The Emerging Roles of Autophagy in Human Diseases
title_fullStr	The Emerging Roles of Autophagy in Human Diseases
title_full_unstemmed	The Emerging Roles of Autophagy in Human Diseases
title_sort	emerging roles of autophagy in human diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/5727582255894113b96780b9d9dd2df8
work_keys_str_mv	AT yuchenlei theemergingrolesofautophagyinhumandiseases AT danieljklionsky theemergingrolesofautophagyinhumandiseases AT yuchenlei emergingrolesofautophagyinhumandiseases AT danieljklionsky emergingrolesofautophagyinhumandiseases
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The Emerging Roles of Autophagy in Human Diseases

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