Tobacco use and age are associated with different morphologic features of anterior communicating artery aneurysms

Abstract We present a cohort of patients with anterior communicating artery (ACoA) aneurysms to investigate morphological characteristics and clinical factors associated with rupture of the aneurysms. 505 patients with ACoA aneurysms were identified at the Brigham and Women’s Hospital and Massachuse...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Jian Zhang, Pui Man Rosalind Lai, Anil Can, Srinivasan Mukundan, Victor M. Castro, Dmitriy Dligach, Sean Finan, Vivian S. Gainer, Nancy A. Shadick, Guergana Savova, Shawn N. Murphy, Tianxi Cai, Scott T. Weiss, Rose Du
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/572b7a424f8544869b1d457a90b1c851
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:572b7a424f8544869b1d457a90b1c851
record_format	dspace
spelling	oai:doaj.org-article:572b7a424f8544869b1d457a90b1c8512021-12-02T13:19:20ZTobacco use and age are associated with different morphologic features of anterior communicating artery aneurysms10.1038/s41598-021-84315-52045-2322https://doaj.org/article/572b7a424f8544869b1d457a90b1c8512021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84315-5https://doaj.org/toc/2045-2322Abstract We present a cohort of patients with anterior communicating artery (ACoA) aneurysms to investigate morphological characteristics and clinical factors associated with rupture of the aneurysms. 505 patients with ACoA aneurysms were identified at the Brigham and Women’s Hospital and Massachusetts General Hospital between 1990 and 2016, with available CT angiography (CTA). Three-dimensional (3D) reconstructions were performed to evaluate aneurysmal morphologic features, including location, projection, irregularity, the presence of daughter dome, height, height/width ratio, and relationships between surrounding vessels. Patient risk factors assessed included patient age, sex, tobacco use, alcohol use, and family history of aneurysms and aneurysmal subarachnoid hemorrhage. Logistic regression was used to build a predictive ACoA score for rupture. Morphologic features associated with ruptured ACoA aneurysms were the presence of a daughter dome (OR 21.4, 95% CI 10.6–43.1), smaller neck diameter (OR 0.55, 95% CI 0.42–0.71), larger aspect ratio (OR 3.57, 95% CI 2.05–6.24), larger flow angle (OR 1.03, 95% CI 1.02–1.05), and smaller ipsilateral A2-ACoA angle (OR 0.98, 95% CI 0.97–1.00). Tobacco use was predominantly associated with morphological factors intrinsic to the aneurysm that were associated with rupture while younger age was also associated with morphologic features extrinsic to the aneurysm that were associated with rupture. The ACoA score had good predictive capacity for rupture with AUC = 0.92 using the 0.632 bootstrap cross-validation for correction of overfitting bias. Ruptured ACoA aneurysms were associated with morphological features that are simple to assess using a simple scoring system. Tobacco use and younger age were predominantly associated with intrinsic and extrinsic morphological features characteristic of rupture, respectively.Jian ZhangPui Man Rosalind LaiAnil CanSrinivasan MukundanVictor M. CastroDmitriy DligachSean FinanVivian S. GainerNancy A. ShadickGuergana SavovaShawn N. MurphyTianxi CaiScott T. WeissRose DuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jian Zhang Pui Man Rosalind Lai Anil Can Srinivasan Mukundan Victor M. Castro Dmitriy Dligach Sean Finan Vivian S. Gainer Nancy A. Shadick Guergana Savova Shawn N. Murphy Tianxi Cai Scott T. Weiss Rose Du Tobacco use and age are associated with different morphologic features of anterior communicating artery aneurysms
description	Abstract We present a cohort of patients with anterior communicating artery (ACoA) aneurysms to investigate morphological characteristics and clinical factors associated with rupture of the aneurysms. 505 patients with ACoA aneurysms were identified at the Brigham and Women’s Hospital and Massachusetts General Hospital between 1990 and 2016, with available CT angiography (CTA). Three-dimensional (3D) reconstructions were performed to evaluate aneurysmal morphologic features, including location, projection, irregularity, the presence of daughter dome, height, height/width ratio, and relationships between surrounding vessels. Patient risk factors assessed included patient age, sex, tobacco use, alcohol use, and family history of aneurysms and aneurysmal subarachnoid hemorrhage. Logistic regression was used to build a predictive ACoA score for rupture. Morphologic features associated with ruptured ACoA aneurysms were the presence of a daughter dome (OR 21.4, 95% CI 10.6–43.1), smaller neck diameter (OR 0.55, 95% CI 0.42–0.71), larger aspect ratio (OR 3.57, 95% CI 2.05–6.24), larger flow angle (OR 1.03, 95% CI 1.02–1.05), and smaller ipsilateral A2-ACoA angle (OR 0.98, 95% CI 0.97–1.00). Tobacco use was predominantly associated with morphological factors intrinsic to the aneurysm that were associated with rupture while younger age was also associated with morphologic features extrinsic to the aneurysm that were associated with rupture. The ACoA score had good predictive capacity for rupture with AUC = 0.92 using the 0.632 bootstrap cross-validation for correction of overfitting bias. Ruptured ACoA aneurysms were associated with morphological features that are simple to assess using a simple scoring system. Tobacco use and younger age were predominantly associated with intrinsic and extrinsic morphological features characteristic of rupture, respectively.
format	article
author	Jian Zhang Pui Man Rosalind Lai Anil Can Srinivasan Mukundan Victor M. Castro Dmitriy Dligach Sean Finan Vivian S. Gainer Nancy A. Shadick Guergana Savova Shawn N. Murphy Tianxi Cai Scott T. Weiss Rose Du
author_facet	Jian Zhang Pui Man Rosalind Lai Anil Can Srinivasan Mukundan Victor M. Castro Dmitriy Dligach Sean Finan Vivian S. Gainer Nancy A. Shadick Guergana Savova Shawn N. Murphy Tianxi Cai Scott T. Weiss Rose Du
author_sort	Jian Zhang
title	Tobacco use and age are associated with different morphologic features of anterior communicating artery aneurysms
title_short	Tobacco use and age are associated with different morphologic features of anterior communicating artery aneurysms
title_full	Tobacco use and age are associated with different morphologic features of anterior communicating artery aneurysms
title_fullStr	Tobacco use and age are associated with different morphologic features of anterior communicating artery aneurysms
title_full_unstemmed	Tobacco use and age are associated with different morphologic features of anterior communicating artery aneurysms
title_sort	tobacco use and age are associated with different morphologic features of anterior communicating artery aneurysms
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/572b7a424f8544869b1d457a90b1c851
work_keys_str_mv	AT jianzhang tobaccouseandageareassociatedwithdifferentmorphologicfeaturesofanteriorcommunicatingarteryaneurysms AT puimanrosalindlai tobaccouseandageareassociatedwithdifferentmorphologicfeaturesofanteriorcommunicatingarteryaneurysms AT anilcan tobaccouseandageareassociatedwithdifferentmorphologicfeaturesofanteriorcommunicatingarteryaneurysms AT srinivasanmukundan tobaccouseandageareassociatedwithdifferentmorphologicfeaturesofanteriorcommunicatingarteryaneurysms AT victormcastro tobaccouseandageareassociatedwithdifferentmorphologicfeaturesofanteriorcommunicatingarteryaneurysms AT dmitriydligach tobaccouseandageareassociatedwithdifferentmorphologicfeaturesofanteriorcommunicatingarteryaneurysms AT seanfinan tobaccouseandageareassociatedwithdifferentmorphologicfeaturesofanteriorcommunicatingarteryaneurysms AT viviansgainer tobaccouseandageareassociatedwithdifferentmorphologicfeaturesofanteriorcommunicatingarteryaneurysms AT nancyashadick tobaccouseandageareassociatedwithdifferentmorphologicfeaturesofanteriorcommunicatingarteryaneurysms AT guerganasavova tobaccouseandageareassociatedwithdifferentmorphologicfeaturesofanteriorcommunicatingarteryaneurysms AT shawnnmurphy tobaccouseandageareassociatedwithdifferentmorphologicfeaturesofanteriorcommunicatingarteryaneurysms AT tianxicai tobaccouseandageareassociatedwithdifferentmorphologicfeaturesofanteriorcommunicatingarteryaneurysms AT scotttweiss tobaccouseandageareassociatedwithdifferentmorphologicfeaturesofanteriorcommunicatingarteryaneurysms AT rosedu tobaccouseandageareassociatedwithdifferentmorphologicfeaturesofanteriorcommunicatingarteryaneurysms
_version_	1718393272658821120

Tobacco use and age are associated with different morphologic features of anterior communicating artery aneurysms

Ejemplares similares