Features of lipid peroxidation and antioxidant protection in Mongoloid men, carriers of non-functional polymorphisms of GSTT1 and GSTM1 genes, with different status of fertility

Background. Genetic factors cause 30-50 % of cases of male infertility different forms. We have conducted the investigation of the lipid peroxidation and antioxidant protection system components, associated with the biotransformation genes polymorphisms, in men with infertility. Aims: to study param...

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Autores principales:	N. A. Kurashova, T. A. Bairova, M. I. Dolgikh, E. V. Osipova, B. G. Dashiev, A. V. Labygina, I. N. Gutnik, I. M. Mikhalevich, L. I. Kolesnikova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2018
Materias:	gstt1 gstm1 oxidative stress male infertility Science Q
Acceso en línea:	https://doaj.org/article/572bf12e5434493a8ad166494e1c56dc
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spelling	oai:doaj.org-article:572bf12e5434493a8ad166494e1c56dc2021-11-23T06:14:40ZFeatures of lipid peroxidation and antioxidant protection in Mongoloid men, carriers of non-functional polymorphisms of GSTT1 and GSTM1 genes, with different status of fertility2541-94202587-959610.29413/ABS.2018-3.3.19https://doaj.org/article/572bf12e5434493a8ad166494e1c56dc2018-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/595https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596Background. Genetic factors cause 30-50 % of cases of male infertility different forms. We have conducted the investigation of the lipid peroxidation and antioxidant protection system components, associated with the biotransformation genes polymorphisms, in men with infertility. Aims: to study parameters of lipid peroxidation and antioxidant defense system associated with polymorphisms of biotransformation genes in infertile Mongoloid men. Materials and methods. The main group included 143 men of reproductive age from Mongoloid population who came to the Public Health Institution "Republican Perinatal Center" in Ulan-Ude with the problem of one year and more infertility after the marriage. Fifty-three almost healthy males with proven fertility were included in the control group. Blood samples of all men were genotyped by glutathione S-transferase (GSTP1, GSTM1, GSTT1) gene family and activity of glutathione system enzymes was determined. Results. In the fertile Mongoloids with non-functional genotype GSTT1(0/0)/GSTM1(0/0) we have established an increase concentration of a-tocopherol in serum, activity of glutathione peroxidase and a decrease in glutathione-S-transferase, as well as a decrease in the concentration of a-tocopherol. In infertile Mongoloids with non-functional GSTT1(0/0)/ GSTM1 (0/0) genotypes, an increase in the tiobarbituric acid reactants, glutathione peroxidase and a decrease in the concentration of a-tocopherol was found in the ejaculate; we also detected a decrease in the concentration of a-tocopherol, the level of oxidized glutathione and glutathione-s-transferase activity. Conclusions. Genetically determined peculiarities of functioning of the xenobiotic biotransformation system make each individual unique with regard to their adaptive capacity - resistance or sensibility to the damaging exo- and endogenous factors.N. A. KurashovaT. A. BairovaM. I. DolgikhE. V. OsipovaB. G. DashievA. V. LabyginaI. N. GutnikI. M. MikhalevichL. I. KolesnikovaScientific Сentre for Family Health and Human Reproduction Problemsarticlegstt1gstm1oxidative stressmale infertilitygstt1gstm1ScienceQRUActa Biomedica Scientifica, Vol 3, Iss 3, Pp 121-126 (2018)
institution	DOAJ
collection	DOAJ
language	RU
topic	gstt1 gstm1 oxidative stress male infertility gstt1 gstm1 Science Q
spellingShingle	gstt1 gstm1 oxidative stress male infertility gstt1 gstm1 Science Q N. A. Kurashova T. A. Bairova M. I. Dolgikh E. V. Osipova B. G. Dashiev A. V. Labygina I. N. Gutnik I. M. Mikhalevich L. I. Kolesnikova Features of lipid peroxidation and antioxidant protection in Mongoloid men, carriers of non-functional polymorphisms of GSTT1 and GSTM1 genes, with different status of fertility
description	Background. Genetic factors cause 30-50 % of cases of male infertility different forms. We have conducted the investigation of the lipid peroxidation and antioxidant protection system components, associated with the biotransformation genes polymorphisms, in men with infertility. Aims: to study parameters of lipid peroxidation and antioxidant defense system associated with polymorphisms of biotransformation genes in infertile Mongoloid men. Materials and methods. The main group included 143 men of reproductive age from Mongoloid population who came to the Public Health Institution "Republican Perinatal Center" in Ulan-Ude with the problem of one year and more infertility after the marriage. Fifty-three almost healthy males with proven fertility were included in the control group. Blood samples of all men were genotyped by glutathione S-transferase (GSTP1, GSTM1, GSTT1) gene family and activity of glutathione system enzymes was determined. Results. In the fertile Mongoloids with non-functional genotype GSTT1(0/0)/GSTM1(0/0) we have established an increase concentration of a-tocopherol in serum, activity of glutathione peroxidase and a decrease in glutathione-S-transferase, as well as a decrease in the concentration of a-tocopherol. In infertile Mongoloids with non-functional GSTT1(0/0)/ GSTM1 (0/0) genotypes, an increase in the tiobarbituric acid reactants, glutathione peroxidase and a decrease in the concentration of a-tocopherol was found in the ejaculate; we also detected a decrease in the concentration of a-tocopherol, the level of oxidized glutathione and glutathione-s-transferase activity. Conclusions. Genetically determined peculiarities of functioning of the xenobiotic biotransformation system make each individual unique with regard to their adaptive capacity - resistance or sensibility to the damaging exo- and endogenous factors.
format	article
author	N. A. Kurashova T. A. Bairova M. I. Dolgikh E. V. Osipova B. G. Dashiev A. V. Labygina I. N. Gutnik I. M. Mikhalevich L. I. Kolesnikova
author_facet	N. A. Kurashova T. A. Bairova M. I. Dolgikh E. V. Osipova B. G. Dashiev A. V. Labygina I. N. Gutnik I. M. Mikhalevich L. I. Kolesnikova
author_sort	N. A. Kurashova
title	Features of lipid peroxidation and antioxidant protection in Mongoloid men, carriers of non-functional polymorphisms of GSTT1 and GSTM1 genes, with different status of fertility
title_short	Features of lipid peroxidation and antioxidant protection in Mongoloid men, carriers of non-functional polymorphisms of GSTT1 and GSTM1 genes, with different status of fertility
title_full	Features of lipid peroxidation and antioxidant protection in Mongoloid men, carriers of non-functional polymorphisms of GSTT1 and GSTM1 genes, with different status of fertility
title_fullStr	Features of lipid peroxidation and antioxidant protection in Mongoloid men, carriers of non-functional polymorphisms of GSTT1 and GSTM1 genes, with different status of fertility
title_full_unstemmed	Features of lipid peroxidation and antioxidant protection in Mongoloid men, carriers of non-functional polymorphisms of GSTT1 and GSTM1 genes, with different status of fertility
title_sort	features of lipid peroxidation and antioxidant protection in mongoloid men, carriers of non-functional polymorphisms of gstt1 and gstm1 genes, with different status of fertility
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2018
url	https://doaj.org/article/572bf12e5434493a8ad166494e1c56dc
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Features of lipid peroxidation and antioxidant protection in Mongoloid men, carriers of non-functional polymorphisms of GSTT1 and GSTM1 genes, with different status of fertility

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