The role of Mediator and Little Elongation Complex in transcription termination
Mediator subunit MED26 was shown to help recruit Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to control the expression of certain genes. Here, the authors provide evidence that MED26 recruits LEC to regulate transcription termination of non-polyadenylated genes, including snRNA...
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2020
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oai:doaj.org-article:572c46f5a5fa44c2988bdd63d44df2412021-12-02T14:41:25ZThe role of Mediator and Little Elongation Complex in transcription termination10.1038/s41467-020-14849-12041-1723https://doaj.org/article/572c46f5a5fa44c2988bdd63d44df2412020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14849-1https://doaj.org/toc/2041-1723Mediator subunit MED26 was shown to help recruit Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to control the expression of certain genes. Here, the authors provide evidence that MED26 recruits LEC to regulate transcription termination of non-polyadenylated genes, including snRNA and replication-dependent histone (RDH) genes at Cajal bodies.Hidehisa TakahashiAmol RanjanShiyuan ChenHidefumi SuzukiMio ShibataTomonori HiroseHiroko HiroseKazunori SasakiRyota AbeKai ChenYanfeng HeYing ZhangIchigaku TakigawaTadasuke TsukiyamaMasashi WatanabeSatoshi FujiiMidori IidaJunichi YamamotoYuki YamaguchiYutaka SuzukiMasaki MatsumotoKeiichi I. NakayamaMichael P. WashburnAnita SarafLaurence FlorensShigeo SatoChieri Tomomori-SatoRonald C. ConawayJoan W. ConawayShigetsugu HatakeyamaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-20 (2020) |
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Science Q Hidehisa Takahashi Amol Ranjan Shiyuan Chen Hidefumi Suzuki Mio Shibata Tomonori Hirose Hiroko Hirose Kazunori Sasaki Ryota Abe Kai Chen Yanfeng He Ying Zhang Ichigaku Takigawa Tadasuke Tsukiyama Masashi Watanabe Satoshi Fujii Midori Iida Junichi Yamamoto Yuki Yamaguchi Yutaka Suzuki Masaki Matsumoto Keiichi I. Nakayama Michael P. Washburn Anita Saraf Laurence Florens Shigeo Sato Chieri Tomomori-Sato Ronald C. Conaway Joan W. Conaway Shigetsugu Hatakeyama The role of Mediator and Little Elongation Complex in transcription termination |
| description |
Mediator subunit MED26 was shown to help recruit Super Elongation Complex (SEC) or Little Elongation Complex (LEC) to control the expression of certain genes. Here, the authors provide evidence that MED26 recruits LEC to regulate transcription termination of non-polyadenylated genes, including snRNA and replication-dependent histone (RDH) genes at Cajal bodies. |
| format |
article |
| author |
Hidehisa Takahashi Amol Ranjan Shiyuan Chen Hidefumi Suzuki Mio Shibata Tomonori Hirose Hiroko Hirose Kazunori Sasaki Ryota Abe Kai Chen Yanfeng He Ying Zhang Ichigaku Takigawa Tadasuke Tsukiyama Masashi Watanabe Satoshi Fujii Midori Iida Junichi Yamamoto Yuki Yamaguchi Yutaka Suzuki Masaki Matsumoto Keiichi I. Nakayama Michael P. Washburn Anita Saraf Laurence Florens Shigeo Sato Chieri Tomomori-Sato Ronald C. Conaway Joan W. Conaway Shigetsugu Hatakeyama |
| author_facet |
Hidehisa Takahashi Amol Ranjan Shiyuan Chen Hidefumi Suzuki Mio Shibata Tomonori Hirose Hiroko Hirose Kazunori Sasaki Ryota Abe Kai Chen Yanfeng He Ying Zhang Ichigaku Takigawa Tadasuke Tsukiyama Masashi Watanabe Satoshi Fujii Midori Iida Junichi Yamamoto Yuki Yamaguchi Yutaka Suzuki Masaki Matsumoto Keiichi I. Nakayama Michael P. Washburn Anita Saraf Laurence Florens Shigeo Sato Chieri Tomomori-Sato Ronald C. Conaway Joan W. Conaway Shigetsugu Hatakeyama |
| author_sort |
Hidehisa Takahashi |
| title |
The role of Mediator and Little Elongation Complex in transcription termination |
| title_short |
The role of Mediator and Little Elongation Complex in transcription termination |
| title_full |
The role of Mediator and Little Elongation Complex in transcription termination |
| title_fullStr |
The role of Mediator and Little Elongation Complex in transcription termination |
| title_full_unstemmed |
The role of Mediator and Little Elongation Complex in transcription termination |
| title_sort |
role of mediator and little elongation complex in transcription termination |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/572c46f5a5fa44c2988bdd63d44df241 |
| work_keys_str_mv |
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