Sex-specific maternofetal innate immune responses triggered by group B Streptococci

Abstract Group B Streptococcus (GBS) is one of the most common bacteria isolated in human chorioamnionitis, which is a major risk factor for premature birth and brain injuries. Males are at greater risk than females for developing lifelong neurobehavioural disorders, although the origins of this sex...

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Autores principales:	Marie-Julie Allard, Antoine Giraud, Mariela Segura, Guillaume Sebire
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/572c5a4163b4466f8d9678f5a41feadc
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spelling	oai:doaj.org-article:572c5a4163b4466f8d9678f5a41feadc2021-12-02T15:09:14ZSex-specific maternofetal innate immune responses triggered by group B Streptococci10.1038/s41598-019-45029-x2045-2322https://doaj.org/article/572c5a4163b4466f8d9678f5a41feadc2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-45029-xhttps://doaj.org/toc/2045-2322Abstract Group B Streptococcus (GBS) is one of the most common bacteria isolated in human chorioamnionitis, which is a major risk factor for premature birth and brain injuries. Males are at greater risk than females for developing lifelong neurobehavioural disorders, although the origins of this sex bias remain poorly understood. We previously showed that end-gestational inflammation triggered by GBS led to early neurodevelopmental impairments mainly in the male rat progeny. Identifying key inflammatory players involved in maternofetal immune activation by specific pathogens is critical to develop appropriate novel therapeutic interventions. We aimed to map out the GBS-induced profile of innate immune biomarkers in the maternal-placental-fetal axis, and to compare this immune profile between male and female tissues. We describe here that the GBS-induced immune signalling involved significantly higher levels of interleukin (IL)-1β, cytokine-induced neutrophil chemoattractant-1 (CINC-1/CXCL1) and polymorphonuclear cells (PMNs) infiltration in male compared to female maternofetal tissues. Although male – but not female – fetuses presented increased levels of IL-1β, fetuses from both sexes in-utero exposed to GBS had increased levels of TNF-α in their circulation. Levels of IL-1β detected in fetal sera correlated positively with the levels found in maternal circulation. Here, we report for the first time that the maternofetal innate immune signalling induced by GBS presents a sexually dichotomous profile, with more prominent inflammation in males than females. These sex-specific placental and fetal pro-inflammatory responses are in keeping with the higher susceptibility of the male population for preterm birth, brain injuries and neurodevelopmental disorders such as cerebral palsy and autism spectrum disorders.Marie-Julie AllardAntoine GiraudMariela SeguraGuillaume SebireNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marie-Julie Allard Antoine Giraud Mariela Segura Guillaume Sebire Sex-specific maternofetal innate immune responses triggered by group B Streptococci
description	Abstract Group B Streptococcus (GBS) is one of the most common bacteria isolated in human chorioamnionitis, which is a major risk factor for premature birth and brain injuries. Males are at greater risk than females for developing lifelong neurobehavioural disorders, although the origins of this sex bias remain poorly understood. We previously showed that end-gestational inflammation triggered by GBS led to early neurodevelopmental impairments mainly in the male rat progeny. Identifying key inflammatory players involved in maternofetal immune activation by specific pathogens is critical to develop appropriate novel therapeutic interventions. We aimed to map out the GBS-induced profile of innate immune biomarkers in the maternal-placental-fetal axis, and to compare this immune profile between male and female tissues. We describe here that the GBS-induced immune signalling involved significantly higher levels of interleukin (IL)-1β, cytokine-induced neutrophil chemoattractant-1 (CINC-1/CXCL1) and polymorphonuclear cells (PMNs) infiltration in male compared to female maternofetal tissues. Although male – but not female – fetuses presented increased levels of IL-1β, fetuses from both sexes in-utero exposed to GBS had increased levels of TNF-α in their circulation. Levels of IL-1β detected in fetal sera correlated positively with the levels found in maternal circulation. Here, we report for the first time that the maternofetal innate immune signalling induced by GBS presents a sexually dichotomous profile, with more prominent inflammation in males than females. These sex-specific placental and fetal pro-inflammatory responses are in keeping with the higher susceptibility of the male population for preterm birth, brain injuries and neurodevelopmental disorders such as cerebral palsy and autism spectrum disorders.
format	article
author	Marie-Julie Allard Antoine Giraud Mariela Segura Guillaume Sebire
author_facet	Marie-Julie Allard Antoine Giraud Mariela Segura Guillaume Sebire
author_sort	Marie-Julie Allard
title	Sex-specific maternofetal innate immune responses triggered by group B Streptococci
title_short	Sex-specific maternofetal innate immune responses triggered by group B Streptococci
title_full	Sex-specific maternofetal innate immune responses triggered by group B Streptococci
title_fullStr	Sex-specific maternofetal innate immune responses triggered by group B Streptococci
title_full_unstemmed	Sex-specific maternofetal innate immune responses triggered by group B Streptococci
title_sort	sex-specific maternofetal innate immune responses triggered by group b streptococci
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/572c5a4163b4466f8d9678f5a41feadc
work_keys_str_mv	AT mariejulieallard sexspecificmaternofetalinnateimmuneresponsestriggeredbygroupbstreptococci AT antoinegiraud sexspecificmaternofetalinnateimmuneresponsestriggeredbygroupbstreptococci AT marielasegura sexspecificmaternofetalinnateimmuneresponsestriggeredbygroupbstreptococci AT guillaumesebire sexspecificmaternofetalinnateimmuneresponsestriggeredbygroupbstreptococci
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Sex-specific maternofetal innate immune responses triggered by group B Streptococci

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