Studies and Application of Sialylated Milk Components on Regulating Neonatal Gut Microbiota and Health

Breast milk is rich in sialic acids (SA), which are commonly combined with milk oligosaccharides and glycoconjugates. As a functional nutrient component, SA-containing milk components have received increasing attention in recent years. Sialylated human milk oligosaccharides (HMOs) have been demonstr...

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Autores principales:	Yushuang Wang, Xiaolei Ze, Binqi Rui, Xinke Li, Nina Zeng, Jieli Yuan, Wenzhe Li, Jingyu Yan, Ming Li
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	breast milk sialic acids oligosaccharides glycoconjugates new-born gut microbiota Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/572cf89248e54d11bfb1f9191e92769d
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spelling	oai:doaj.org-article:572cf89248e54d11bfb1f9191e92769d2021-11-10T10:01:23ZStudies and Application of Sialylated Milk Components on Regulating Neonatal Gut Microbiota and Health2296-861X10.3389/fnut.2021.766606https://doaj.org/article/572cf89248e54d11bfb1f9191e92769d2021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnut.2021.766606/fullhttps://doaj.org/toc/2296-861XBreast milk is rich in sialic acids (SA), which are commonly combined with milk oligosaccharides and glycoconjugates. As a functional nutrient component, SA-containing milk components have received increasing attention in recent years. Sialylated human milk oligosaccharides (HMOs) have been demonstrated to promote the growth and metabolism of beneficial gut microbiota in infants, bringing positive outcomes to intestinal health and immune function. They also exhibit antiviral and bacteriostatic activities in the intestinal mucosa of new-borns, thereby inhibiting the adhesion of pathogens to host cells. These properties play a pivotal role in regulating the intestinal microbial ecosystem and preventing the occurrence of neonatal inflammatory diseases. In addition, some recent studies also support the promoting effects of sialylated HMOs on neonatal bone and brain development. In addition to HMOs, sialylated glycoproteins and glycolipids are abundant in milk, and are also critical to neonatal health. This article reviews the current research progress in the regulation of sialylated milk oligosaccharides and glycoconjugates on neonatal gut microbiota and health.Yushuang WangXiaolei ZeBinqi RuiXinke LiNina ZengJieli YuanWenzhe LiJingyu YanMing LiFrontiers Media S.A.articlebreast milksialic acidsoligosaccharidesglycoconjugatesnew-borngut microbiotaNutrition. Foods and food supplyTX341-641ENFrontiers in Nutrition, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	breast milk sialic acids oligosaccharides glycoconjugates new-born gut microbiota Nutrition. Foods and food supply TX341-641
spellingShingle	breast milk sialic acids oligosaccharides glycoconjugates new-born gut microbiota Nutrition. Foods and food supply TX341-641 Yushuang Wang Xiaolei Ze Binqi Rui Xinke Li Nina Zeng Jieli Yuan Wenzhe Li Jingyu Yan Ming Li Studies and Application of Sialylated Milk Components on Regulating Neonatal Gut Microbiota and Health
description	Breast milk is rich in sialic acids (SA), which are commonly combined with milk oligosaccharides and glycoconjugates. As a functional nutrient component, SA-containing milk components have received increasing attention in recent years. Sialylated human milk oligosaccharides (HMOs) have been demonstrated to promote the growth and metabolism of beneficial gut microbiota in infants, bringing positive outcomes to intestinal health and immune function. They also exhibit antiviral and bacteriostatic activities in the intestinal mucosa of new-borns, thereby inhibiting the adhesion of pathogens to host cells. These properties play a pivotal role in regulating the intestinal microbial ecosystem and preventing the occurrence of neonatal inflammatory diseases. In addition, some recent studies also support the promoting effects of sialylated HMOs on neonatal bone and brain development. In addition to HMOs, sialylated glycoproteins and glycolipids are abundant in milk, and are also critical to neonatal health. This article reviews the current research progress in the regulation of sialylated milk oligosaccharides and glycoconjugates on neonatal gut microbiota and health.
format	article
author	Yushuang Wang Xiaolei Ze Binqi Rui Xinke Li Nina Zeng Jieli Yuan Wenzhe Li Jingyu Yan Ming Li
author_facet	Yushuang Wang Xiaolei Ze Binqi Rui Xinke Li Nina Zeng Jieli Yuan Wenzhe Li Jingyu Yan Ming Li
author_sort	Yushuang Wang
title	Studies and Application of Sialylated Milk Components on Regulating Neonatal Gut Microbiota and Health
title_short	Studies and Application of Sialylated Milk Components on Regulating Neonatal Gut Microbiota and Health
title_full	Studies and Application of Sialylated Milk Components on Regulating Neonatal Gut Microbiota and Health
title_fullStr	Studies and Application of Sialylated Milk Components on Regulating Neonatal Gut Microbiota and Health
title_full_unstemmed	Studies and Application of Sialylated Milk Components on Regulating Neonatal Gut Microbiota and Health
title_sort	studies and application of sialylated milk components on regulating neonatal gut microbiota and health
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/572cf89248e54d11bfb1f9191e92769d
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Studies and Application of Sialylated Milk Components on Regulating Neonatal Gut Microbiota and Health

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