HIV clinical stages and lower extremity arterial disease among HIV infected outpatients in Burundi

Abstract Chronic disease of people living with human immunodeficiency virus (HIV) infection are now approaching those of the general population. Previous, in vitro studies shown that HIV causes arterial injuries resulting in inflammation and atherosclerosis but direct relationship between HIV infect...

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Autores principales:	Ileana Desormais, Deo Harimenshi, Théodore Niyongabo, Philippe Lacroix, Victor Aboyans, Pierre Marie Preux
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/573265a69009485cba6788c1d1edb9ac
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spelling	oai:doaj.org-article:573265a69009485cba6788c1d1edb9ac2021-12-02T14:27:56ZHIV clinical stages and lower extremity arterial disease among HIV infected outpatients in Burundi10.1038/s41598-021-87862-z2045-2322https://doaj.org/article/573265a69009485cba6788c1d1edb9ac2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87862-zhttps://doaj.org/toc/2045-2322Abstract Chronic disease of people living with human immunodeficiency virus (HIV) infection are now approaching those of the general population. Previous, in vitro studies shown that HIV causes arterial injuries resulting in inflammation and atherosclerosis but direct relationship between HIV infection clinical stages and lower extremity arterial disease (LEAD) remain controversial. No study assessed, with an accurate method, both the prevalence of LEAD and the influence of HIV severity on LEAD in HIV outpatients in Central Africa. A cross-sectional study was conducted among 300 HIV-infected outpatients, aged ≥ 40 years in Bujumbura, Burundi. All patients underwent ankle-brachial index (ABI) measurement and LEAD was diagnosed by ABI ≤ 0.9. The prevalence of LEAD was 17.3% (CI 95% 13.2–22.1). The mean age was 49.6 ± 7.1 years. On multivariable analysis, factors associated with LEAD were hypertension (OR = 2.42; 95% CI 1.10–5.80), and stage IV HIV clinical infection (OR = 4.92, 95% CI 1.19–20.36). This is the first study performed on a large HIV population in Central Africa, reporting high LEAD prevalence. It underlines the influence of HIV infection on peripheral atherosclerosis at latest clinical stages and the need for LEAD screening in HIV-infected patients.Ileana DesormaisDeo HarimenshiThéodore NiyongaboPhilippe LacroixVictor AboyansPierre Marie PreuxNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ileana Desormais Deo Harimenshi Théodore Niyongabo Philippe Lacroix Victor Aboyans Pierre Marie Preux HIV clinical stages and lower extremity arterial disease among HIV infected outpatients in Burundi
description	Abstract Chronic disease of people living with human immunodeficiency virus (HIV) infection are now approaching those of the general population. Previous, in vitro studies shown that HIV causes arterial injuries resulting in inflammation and atherosclerosis but direct relationship between HIV infection clinical stages and lower extremity arterial disease (LEAD) remain controversial. No study assessed, with an accurate method, both the prevalence of LEAD and the influence of HIV severity on LEAD in HIV outpatients in Central Africa. A cross-sectional study was conducted among 300 HIV-infected outpatients, aged ≥ 40 years in Bujumbura, Burundi. All patients underwent ankle-brachial index (ABI) measurement and LEAD was diagnosed by ABI ≤ 0.9. The prevalence of LEAD was 17.3% (CI 95% 13.2–22.1). The mean age was 49.6 ± 7.1 years. On multivariable analysis, factors associated with LEAD were hypertension (OR = 2.42; 95% CI 1.10–5.80), and stage IV HIV clinical infection (OR = 4.92, 95% CI 1.19–20.36). This is the first study performed on a large HIV population in Central Africa, reporting high LEAD prevalence. It underlines the influence of HIV infection on peripheral atherosclerosis at latest clinical stages and the need for LEAD screening in HIV-infected patients.
format	article
author	Ileana Desormais Deo Harimenshi Théodore Niyongabo Philippe Lacroix Victor Aboyans Pierre Marie Preux
author_facet	Ileana Desormais Deo Harimenshi Théodore Niyongabo Philippe Lacroix Victor Aboyans Pierre Marie Preux
author_sort	Ileana Desormais
title	HIV clinical stages and lower extremity arterial disease among HIV infected outpatients in Burundi
title_short	HIV clinical stages and lower extremity arterial disease among HIV infected outpatients in Burundi
title_full	HIV clinical stages and lower extremity arterial disease among HIV infected outpatients in Burundi
title_fullStr	HIV clinical stages and lower extremity arterial disease among HIV infected outpatients in Burundi
title_full_unstemmed	HIV clinical stages and lower extremity arterial disease among HIV infected outpatients in Burundi
title_sort	hiv clinical stages and lower extremity arterial disease among hiv infected outpatients in burundi
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/573265a69009485cba6788c1d1edb9ac
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HIV clinical stages and lower extremity arterial disease among HIV infected outpatients in Burundi

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