The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat.

<h4>Background and aims</h4>A polymorphism in adiponutrin/patatin-like phospholipase-3 gene (PNPLA3), rs738409 C->G, encoding for the I148M variant, is the strongest genetic determinant of liver fat and ALT levels in adulthood and childhood obesity. Aims of this study were i) to analy...

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Auteurs principaux: Emanuele Miraglia del Giudice, Anna Grandone, Grazia Cirillo, Nicola Santoro, Alessandra Amato, Carmine Brienza, Piera Savarese, Pierluigi Marzuillo, Laura Perrone
Format: article
Langue:EN
Publié: Public Library of Science (PLoS) 2011
Sujets:
R
Q
Accès en ligne:https://doaj.org/article/57375d409ca54adb9abdbe4642d68610
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