Sarcopenia is associated with decreased gray matter volume in the parietal lobe: a longitudinal cohort study

Abstract Background Substantial evidence supports an association between physical activity and cognitive function. However, the role of muscle mass and function in brain structural changes is not well known. This study investigated whether sarcopenia, defined as low muscle mass and strength, acceler...

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Autores principales:	Ji Hee Yu, Regina E. Y. Kim, Jin-Man Jung, So Young Park, Da Young Lee, Hyun Joo Cho, Nam Hoon Kim, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Chol Shin, Nan Hee Kim
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Sarcopenia Skeletal muscle Muscle strength Brain atrophy Gray matter Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/5738ffc75d7a4bd2811441f124ec874c
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spelling	oai:doaj.org-article:5738ffc75d7a4bd2811441f124ec874c2021-11-07T12:16:16ZSarcopenia is associated with decreased gray matter volume in the parietal lobe: a longitudinal cohort study10.1186/s12877-021-02581-41471-2318https://doaj.org/article/5738ffc75d7a4bd2811441f124ec874c2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12877-021-02581-4https://doaj.org/toc/1471-2318Abstract Background Substantial evidence supports an association between physical activity and cognitive function. However, the role of muscle mass and function in brain structural changes is not well known. This study investigated whether sarcopenia, defined as low muscle mass and strength, accelerates brain volume atrophy. Methods A total of 1284 participants with sarcopenic measurements and baseline and 4-year follow-up brain magnetic resonance images were recruited from the Korean Genome and Epidemiology Study. Muscle mass was represented as appendicular skeletal muscle mass divided by the body mass index. Muscle function was measured by handgrip strength. The low mass and strength groups were defined as being in the lowest quintile of each variable for one’s sex. Sarcopenia was defined as being in the lowest quintile for both muscle mass and handgrip strength. Results Of the 1284 participants, 12·6%, 10·8%, and 5·4% were classified as the low mass, low strength, and sarcopenia groups, respectively. The adjusted mean changes of gray matter (GM) volume during 4-year follow-up period were − 9·6 mL in the control group, whereas − 11·6 mL in the other three groups (P < 0·001). The significantly greater atrophy in parietal GM was observed in the sarcopenia group compared with the control group. In a joint regression model, low muscle mass, but not muscle strength, was an independent factor associated with a decrease of GM volume. Conclusions Sarcopenia is associated with parietal GM volume atrophy, in a middle-aged population. Maintaining good levels of muscle mass could be important for brain health in later adulthood.Ji Hee YuRegina E. Y. KimJin-Man JungSo Young ParkDa Young LeeHyun Joo ChoNam Hoon KimHye Jin YooJi A SeoSin Gon KimKyung Mook ChoiSei Hyun BaikChol ShinNan Hee KimBMCarticleSarcopeniaSkeletal muscleMuscle strengthBrain atrophyGray matterGeriatricsRC952-954.6ENBMC Geriatrics, Vol 21, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Sarcopenia Skeletal muscle Muscle strength Brain atrophy Gray matter Geriatrics RC952-954.6
spellingShingle	Sarcopenia Skeletal muscle Muscle strength Brain atrophy Gray matter Geriatrics RC952-954.6 Ji Hee Yu Regina E. Y. Kim Jin-Man Jung So Young Park Da Young Lee Hyun Joo Cho Nam Hoon Kim Hye Jin Yoo Ji A Seo Sin Gon Kim Kyung Mook Choi Sei Hyun Baik Chol Shin Nan Hee Kim Sarcopenia is associated with decreased gray matter volume in the parietal lobe: a longitudinal cohort study
description	Abstract Background Substantial evidence supports an association between physical activity and cognitive function. However, the role of muscle mass and function in brain structural changes is not well known. This study investigated whether sarcopenia, defined as low muscle mass and strength, accelerates brain volume atrophy. Methods A total of 1284 participants with sarcopenic measurements and baseline and 4-year follow-up brain magnetic resonance images were recruited from the Korean Genome and Epidemiology Study. Muscle mass was represented as appendicular skeletal muscle mass divided by the body mass index. Muscle function was measured by handgrip strength. The low mass and strength groups were defined as being in the lowest quintile of each variable for one’s sex. Sarcopenia was defined as being in the lowest quintile for both muscle mass and handgrip strength. Results Of the 1284 participants, 12·6%, 10·8%, and 5·4% were classified as the low mass, low strength, and sarcopenia groups, respectively. The adjusted mean changes of gray matter (GM) volume during 4-year follow-up period were − 9·6 mL in the control group, whereas − 11·6 mL in the other three groups (P < 0·001). The significantly greater atrophy in parietal GM was observed in the sarcopenia group compared with the control group. In a joint regression model, low muscle mass, but not muscle strength, was an independent factor associated with a decrease of GM volume. Conclusions Sarcopenia is associated with parietal GM volume atrophy, in a middle-aged population. Maintaining good levels of muscle mass could be important for brain health in later adulthood.
format	article
author	Ji Hee Yu Regina E. Y. Kim Jin-Man Jung So Young Park Da Young Lee Hyun Joo Cho Nam Hoon Kim Hye Jin Yoo Ji A Seo Sin Gon Kim Kyung Mook Choi Sei Hyun Baik Chol Shin Nan Hee Kim
author_facet	Ji Hee Yu Regina E. Y. Kim Jin-Man Jung So Young Park Da Young Lee Hyun Joo Cho Nam Hoon Kim Hye Jin Yoo Ji A Seo Sin Gon Kim Kyung Mook Choi Sei Hyun Baik Chol Shin Nan Hee Kim
author_sort	Ji Hee Yu
title	Sarcopenia is associated with decreased gray matter volume in the parietal lobe: a longitudinal cohort study
title_short	Sarcopenia is associated with decreased gray matter volume in the parietal lobe: a longitudinal cohort study
title_full	Sarcopenia is associated with decreased gray matter volume in the parietal lobe: a longitudinal cohort study
title_fullStr	Sarcopenia is associated with decreased gray matter volume in the parietal lobe: a longitudinal cohort study
title_full_unstemmed	Sarcopenia is associated with decreased gray matter volume in the parietal lobe: a longitudinal cohort study
title_sort	sarcopenia is associated with decreased gray matter volume in the parietal lobe: a longitudinal cohort study
publisher	BMC
publishDate	2021
url	https://doaj.org/article/5738ffc75d7a4bd2811441f124ec874c
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Sarcopenia is associated with decreased gray matter volume in the parietal lobe: a longitudinal cohort study

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