IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer

Membrane contact sites between the ER and mitochondria are known to convey calcium signals between these two organelles via IP3 receptors, but the molecular mechanisms are currently unclear. Here, the authors show that IP3 receptors play a structural tethering role in maintaining ER-mitochondrial co...

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Autores principales:	Adam Bartok, David Weaver, Tünde Golenár, Zuzana Nichtova, Máté Katona, Száva Bánsághi, Kamil J. Alzayady, V. Kaye Thomas, Hideaki Ando, Katsuhiko Mikoshiba, Suresh K. Joseph, David I. Yule, György Csordás, György Hajnóczky
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/573c9a6e3c934f97817996bbe29c011b
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spelling	oai:doaj.org-article:573c9a6e3c934f97817996bbe29c011b2021-12-02T15:35:29ZIP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer10.1038/s41467-019-11646-32041-1723https://doaj.org/article/573c9a6e3c934f97817996bbe29c011b2019-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11646-3https://doaj.org/toc/2041-1723Membrane contact sites between the ER and mitochondria are known to convey calcium signals between these two organelles via IP3 receptors, but the molecular mechanisms are currently unclear. Here, the authors show that IP3 receptors play a structural tethering role in maintaining ER-mitochondrial contacts.Adam BartokDavid WeaverTünde GolenárZuzana NichtovaMáté KatonaSzáva BánsághiKamil J. AlzayadyV. Kaye ThomasHideaki AndoKatsuhiko MikoshibaSuresh K. JosephDavid I. YuleGyörgy CsordásGyörgy HajnóczkyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Adam Bartok David Weaver Tünde Golenár Zuzana Nichtova Máté Katona Száva Bánsághi Kamil J. Alzayady V. Kaye Thomas Hideaki Ando Katsuhiko Mikoshiba Suresh K. Joseph David I. Yule György Csordás György Hajnóczky IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer
description	Membrane contact sites between the ER and mitochondria are known to convey calcium signals between these two organelles via IP3 receptors, but the molecular mechanisms are currently unclear. Here, the authors show that IP3 receptors play a structural tethering role in maintaining ER-mitochondrial contacts.
format	article
author	Adam Bartok David Weaver Tünde Golenár Zuzana Nichtova Máté Katona Száva Bánsághi Kamil J. Alzayady V. Kaye Thomas Hideaki Ando Katsuhiko Mikoshiba Suresh K. Joseph David I. Yule György Csordás György Hajnóczky
author_facet	Adam Bartok David Weaver Tünde Golenár Zuzana Nichtova Máté Katona Száva Bánsághi Kamil J. Alzayady V. Kaye Thomas Hideaki Ando Katsuhiko Mikoshiba Suresh K. Joseph David I. Yule György Csordás György Hajnóczky
author_sort	Adam Bartok
title	IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer
title_short	IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer
title_full	IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer
title_fullStr	IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer
title_full_unstemmed	IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer
title_sort	ip3 receptor isoforms differently regulate er-mitochondrial contacts and local calcium transfer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/573c9a6e3c934f97817996bbe29c011b
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IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer

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